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Nanoantibiotic Particles for Shape and Size Recognition of Pathogens

Published online by Cambridge University Press:  14 January 2013

Josef Borovicka ,
Simeon D. Stoyanov  and
Vesselin N. Paunov
Josef Borovicka
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK
Simeon D. Stoyanov
Affiliation:
Unilever R&D, Olivier van Noortlaan 120, 3133 AT Vlaardingen, the Netherlands.
Vesselin N. Paunov*
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK
*
*Corresponding author. Email: V.N.Paunov@hull.ac.uk, Phone : +44 1482 465660, Fax : +44 1482 466410.
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Abstract

We have developed a novel class of colloidal particles capable of shape and size recognition as well as specific binding to the target cells. These colloid particles were fabricated using a nanoimprinting technology which yields inorganic imprints of the chosen target microorganisms. The products of the templating process are partially fragmented inorganic shells which can selectively bind to their biological counterparts, therefore impairing microbial cell growth, replication and infection. We have named this class of particles, which are capable of selectively recognizing bacterial shape and size, “nanoantibiotics”, which can be further functionalized to kill the target cells. The selective binding is driven by the increased area of contact upon recognition of the cell shape and size between the cells and their matching inorganic shell fragments. Here, we demonstrate the cell recognition and binding action of such particles using two different microbial test organisms.

Keywords

colloidnanostructurebiomaterial
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1498: Symposium L – Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications , 2013 , pp. 127 - 132
Copyright
Copyright © Materials Research Society 2013 

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References

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