Epidemiology and Infection

Original Papers

TB, other bacteria

Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England

K. E. CHAPMANa1 c1, D. WILSONa2 and R. GORTONa1

a1 Health Protection Agency North East, North East Regional Epidemiology Unit, Gallowgate, Newcastle upon Tyne, UK

a2 Health Protection Agency North East, North East Health Protection Unit, Gallowgate, Newcastle upon Tyne, UK

SUMMARY

The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A population-based study of serotypes causing invasive pneumococcal disease (IPD) post-PCV7 in North East England was conducted using data from a regional enhanced IPD surveillance system. Overall, there was a 20% reduction [95% confidence interval (CI) 5–32] from 12·1 cases/100 000 population in 2006/2007 to 9·7 in 2009/2010. There was a fall in IPD caused by PCV7 serotypes in all age groups, with reductions of 90% (95% CI 61–99) in children aged <5 years, 50% (95% CI 4–75) in persons aged 5–64 years and 66% (95% CI 40–82) in adults aged ≥65 years. There was a non-significant increase in IPD caused by non-PCV7 serotypes in children aged <5 years of 88% (95% CI −10 to 312) and adults aged ≥65 years of 12% (95% CI −19 to 50), which was largely caused by serotypes 7F, 19A and 22F. Replacement disease appears to have reduced the benefits of PCV7 in North East England.

(Received September 05 2011)

(Revised March 09 2012)

(Accepted April 02 2012)

(Online publication May 08 2012)

Key words

  • Invasive pneumococcal disease;
  • pneumococcal conjugate vaccine;
  • Streptococcus pneumoniae (pneumococcus)

Correspondence:

c1 Author for correspondence: Dr K. E. Chapman, Health Protection Agency North East, North East Regional Epidemiology Unit, Floor 2, Citygate, Gallowgate, Newcastle upon Tyne, NE1 4WH, UK. (Email: kaye.chapman@hpa.org.uk)

Footnotes

  Some of these data were presented as a poster presentation at the 7th International Symposium on Pneumococci and Pneumococcal Disease, Tel Aviv, Israel, March 2010.

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