a1 Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Unité Maladies Métaboliques et Micronutriments, INRA, Theix, 63122 Saint-Genès-Champanelle, France
The present study examined the effects of Se, vitamin E and combined Se and vitamin E deficiencies in rats on plasma lipid, Lipoprotein and apolipoprotein (apo) concentrations. Deficiencies were induced by feeding rats the respective diets for 6 weeks. The study shows that Se deficiency results in increased concentrations of plasma cholesterol and apo E. Both could be explained by an increase in the HDL1 fraction. Vitamin E deficiency alone had no significant effect on plasma lipid, lipoprotein and apo concentrations. Se deficiency in combination with vitamin E deficiency leads to an increase in plasma LDL and apo B concentrations. These results point to the need for further investigations on the mechanism by which Se deficiency affects lipoprotein metabolism.
(Received November 20 1995)
(Revised March 25 1996)
(Accepted April 17 1996)
p1 Department of Medicine, University of Chicago, Chicago, IL 60637, USA.