a1 National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control (SKLID), China Centre for Disease Control and Prevention, Beijing, People's Republic of China
a2 JiNan Municipal Centre For Disease control and prevention, Jinan, Shandong, People's Republic of China
The phylogenetic and epidemic relationships of 104 clinical isolates of Clostridium difficile from three hospitals of different geographical and population sources in China were investigated by multilocus sequence typing. Twenty-two sequence types (STs) were identified, four of which, ST117, ST118, ST119 and ST129, were novel. No geographically specific and host population-specific phylogenetic lineages were found and there was no correlation between geographical origin or host population and strain genotype. ST37 was the dominant type in our survey but the four novel STs underline the high genetic diversity and unique polymorphisms in C. difficile from China.
(Received December 28 2011)
(Revised February 21 2012)
(Accepted February 21 2012)
(Online publication April 04 2012)
c1 Author for correspondence: Professor J. Lu or Professor Y. Cheng, 155 Changbai Road, Department of Hospital Acquired Infection Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China Centre for Disease Control and Prevention, Changping, Beijing, 102206, People's Republic of China. (Email: firstname.lastname@example.org) [J. Lu] (Email: email@example.com) [Y. Cheng]
† These authors contributed equally to this work.