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Electrochemical Deposition and Evaluation of Conductive Polymer Coating on Biodegradable Magnesium Implants for Neural Applications

Published online by Cambridge University Press:  01 October 2012

Meriam A. Sebaa
Affiliation:
Department of Bioengineering, University of California, Riverside, CA92521
Shan Dhillon
Affiliation:
Department of Bioengineering, University of California, Riverside, CA92521
Huinan Liu*
Affiliation:
Department of Bioengineering, University of California, Riverside, CA92521 Materials Science and Engineering Program, University of California, Riverside, CA92521
*
#corresponding to huinan.liu@ucr.edu
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Abstract

In an attempt to develop conductive, biodegradable, mechanically strong, and biocompatible nerve conduits, pure magnesium (Mg) was used as the biodegradable substrate material to provide strength while the conductive polymer, poly(3,4ethylenedioxythiophene) (PEDOT) was used as a conductive coating material to control Mg degradation and improve cytocompatibility of Mg substrates. This study explored a series of electrochemical deposition conditions to produce a uniform, consistent PEDOT coating on Mg substrates. The microstructure and morphology of the coating and Mg were visualized using scanning electron microscopy (SEM). The elemental composition of the surface was quantified using energy dispersive X-ray spectroscopy (EDS). Adhesion strength of the coating was measured using the tape test following the ASTM-D 3359 standard. The SEM results showed uniform and consistent PEDOT coating, and EDS analysis confirmed the elemental composition of PEDOT. The adhesion strength of PEDOT coating was within the classifications of 3B to 4B.

Type
Articles
Copyright
Copyright © Materials Research Society 2012

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Footnotes

*

Equally contributed;

References

REFERENCES

Muir, K.W., New experimental and clinical data on the efficacy of pharmacological magnesium infusions in cerebral infarcts. Magnesium Research, 1998. 11(1): p. 4356.Google ScholarPubMed
Clarkson, A.N., Anesthetic-mediated protection/preconditioning during cerebral ischemia. Life Sciences, 2007. 80(13): p. 11571175.10.1016/j.lfs.2006.12.022CrossRefGoogle ScholarPubMed
Gupta, V.K., Intravenous magnesium for neuroprotection in acute stroke: Clinical hope versus basic neuropharmacology. Stroke, 2004. 35(12): p. 27582758.10.1161/01.STR.0000147971.14988.50CrossRefGoogle ScholarPubMed
Saver, J.L., et al. ., Prehospital neuroprotective therapy for acute stroke - Results of the field administration of stroke therapy-magnesium (FAST-MAG) pilot trial. Stroke, 2004. 35(5): p. E106-E108.10.1161/01.STR.0000124458.98123.52CrossRefGoogle ScholarPubMed
Campbell, K., et al. ., Magnesium treatment and spontaneous mild hypothermia after transient focal cerebral ischemia in the rat. Brain Research Bulletin, 2008. 77(5): p. 320322.10.1016/j.brainresbull.2008.08.017CrossRefGoogle ScholarPubMed
Kohno, H., et al. ., Three-day magnesium administration prevents atrial fibrillation after coronary artery bypass grafting. Annals of Thoracic Surgery, 2005. 79(1): p. 117126.10.1016/j.athoracsur.2004.06.062CrossRefGoogle ScholarPubMed
Waligorski, S., et al. ., Assessment of the role of magnesium supplementation in prevention of atrial fibrillation in patients after coronary bypass grafting operations. Kardiochirurgia I Torakochirurgia Polska, 2010. 7(2): p. 141145.Google Scholar
Zhang, S.X., et al. ., Research on an Mg-Zn alloy as a degradable biomaterial. Acta Biomaterialia, 2010. 6(2): p. 626640.10.1016/j.actbio.2009.06.028CrossRefGoogle ScholarPubMed
Witte, F., et al. ., Degradable biomaterials based on magnesium corrosion. Current Opinion in Solid State & Materials Science, 2008. 12(5-6): p. 6372.10.1016/j.cossms.2009.04.001CrossRefGoogle Scholar
Richardson-Burns, S.M., et al. ., Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells. Biomaterials, 2007. 28(8): p. 15391552.10.1016/j.biomaterials.2006.11.026CrossRefGoogle ScholarPubMed
Luo, S.C., et al. ., Poly(3,4-ethylenedioxythiophene) (PEDOT) nanobiointerfaces: Thin, ultrasmooth, and functionalized PEDOT films with in vitro and in vivo biocompatibility. Langmuir, 2008. 24(15): p. 80718077.10.1021/la800333gCrossRefGoogle ScholarPubMed
Cui, X.Y. and Martin, D.C., Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays. Sensors and Actuators B-Chemical, 2003. 89(1-2): p. 92102.10.1016/S0925-4005(02)00448-3CrossRefGoogle Scholar
Yang, J.Y. and Martin, D.C., Microporous conducting polymers on neural microelectrode arrays II. Physical characterization. Sensors and Actuators a-Physical, 2004. 113(2): p. 204211.10.1016/j.sna.2004.02.029CrossRefGoogle Scholar
Cui, X.Y.T. and Luo, X.L., Electrochemical deposition of conducting polymer coatings on magnesium surfaces in ionic liquid. Acta Biomaterialia, 2011. 7(1): p. 441446.Google Scholar
Tamburri, E., et al. ., Study of PEDOT conductive polymer films by admittance measurements. Materials Chemistry and Physics, 2011. 125(3): p. 397404.10.1016/j.matchemphys.2010.10.042CrossRefGoogle Scholar
Chandrasekhar, P., ed. Conducting Polymers Fundamentals and Applications. 1999, Springer.10.1007/978-1-4615-5245-1CrossRefGoogle Scholar
Peter, J Blau, K.G.B., Development and use of ASTM standards for wear testing. Wear 1999. 225-229(part 2): p. 11591170.Google Scholar
Takuma Muto, M.I., Kobayashi, Koichi, Miyasaka, Tsutomu, Conductive Polymer-based Mesoscopic Counterelectrodes for Plastic Dye-sensitized Solar Cells. Chemistry Letters, 2007. 36(6): p. 804805.10.1246/cl.2007.804CrossRefGoogle Scholar