Epidemiology and Infection

Intestinal infections

Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium in cattle in England and Wales

R. COXa1a2 c1, T. SUa3, H. CLOUGHa1, M. J. WOODWARDa4 and C. SHERLOCKa1a3

a1 National Centre for Zoonosis Research, Leahurst, University of Liverpool, Wirral, UK

a2 Centre for Veterinary Epidemiological Research, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada

a3 Department of Mathematics and Statistics, Lancaster University, Lancaster, UK

a4 Department of Bacteriology, Animal Health and Veterinary Laboratories Agency, Addlestone, Surrey, UK

SUMMARY

Salmonella is the second most commonly reported human foodborne pathogen in England and Wales, and antimicrobial-resistant strains of Salmonella are an increasing problem in both human and veterinary medicine. In this work we used a generalized linear spatial model to estimate the spatial and temporal patterns of antimicrobial resistance in Salmonella Typhimurium in England and Wales. Of the antimicrobials considered we found a common peak in the probability that an S. Typhimurium incident will show resistance to a given antimicrobial in late spring and in mid to late autumn; however, for one of the antimicrobials (streptomycin) there was a sharp drop, over the last 18 months of the period of investigation, in the probability of resistance. We also found a higher probability of resistance in North Wales which is consistent across the antimicrobials considered. This information contributes to our understanding of the epidemiology of antimicrobial resistance in Salmonella.

(Accepted November 25 2011)

(Online publication January 03 2012)

Correspondence:

c1 Author for correspondence: Dr R. Cox, Centre for Veterinary Epidemiological Research, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. (Email: rucox@upei.ca)

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