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Smart polymers and interfaces for dynamic cell-biomaterials interactions

Published online by Cambridge University Press:  12 September 2012

Stephen Kustra  and
Christopher J. Bettinger
Stephen Kustra
Affiliation:
Carnegie Mellon University, Pittsburgh, PA; skustra@andrew.cmu.edu
Christopher J. Bettinger
Affiliation:
Carnegie Mellon University, Pittsburgh, PA; cbetting@andrew.cmu.edu
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Abstract

Fundamental aspects of the interactions between cells and biomaterials provide a crucial framework for the design of many systems that interact with the human body. A comprehensive understanding of multifactorial processes may provide an adequate basis for the rational design of implantable devices ranging from nanoparticles for drug delivery and scaffolds for tissue engineering, to artificial organs for augmentation and rehabilitation. Recent progress in the elucidation of cell-biomaterials interactions has been predicated on advances in polymer chemistry, materials engineering, and device microfabrication. The confluence of these developments has stimulated a newfound ability to design soft materials and interfaces with precise chemical, physical, and mechanical properties. While static surfaces can yield insight into the interaction of mammalian cells with medical materials, the study of fundamental cell-biomaterials phenomena will benefit significantly from the ability to present biologically active signals to cells with spatiotemporal control. Specifically, the use of dynamic materials and interfaces can mirror the intrinsic dynamic behavior of living cells. This article highlights recent advances in soft materials design, interfacial engineering, and synthetic polymer networks in the context of producing dynamic materials to study cell-biomaterials interactions. Emerging challenges and future research directions are also discussed.

Keywords

Polymerbiomaterialmicrostructurenanostructure
Type
Research Article
Information
MRS Bulletin , Volume 37 , Issue 9 , September 2012 , pp. 836 - 846
Copyright
Copyright © Materials Research Society 2012

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References

Ziats, N.P., Miller, K.M., Anderson, J.M., Biomaterials 9, 5 (1988).CrossRefGoogle ScholarPubMed
Anderson, J.M., Rodriguez, A., Chang, D.T., Semin. Immunol. 20, 86 (2008).CrossRefGoogle Scholar
Voskerician, G., Shive, M.S., Shawgo, R.S., Recum, H.v., Anderson, J.M., Cima, M.J., Langer, R., Biomaterials 24, 1959 (2003).CrossRefGoogle Scholar
Chen, S., Jones, J.A., Xu, Y., Low, H.-Y., Anderson, J.M., Leong, K.W., Biomaterials 31, 3479 (2010).CrossRefGoogle Scholar
Anderson, J., McNally, A., Semin. Immunopathol. 33, 221 (2011).CrossRefGoogle Scholar
Chen, C.S., Mrksich, M., Huang, S., Whitesides, G.M., Ingber, D.E., Science 276, 1425 (1997).CrossRefGoogle Scholar
Yim, E.K.F., Reano, R.M., Pang, S.W., Yee, A.F., Chen, C.S., Leong, K.W., Biomaterials 26, 5405 (2005).CrossRefGoogle Scholar
Yim, E.K.F., Pang, S.W., Leong, K.W., Exp. Cell Res. 313, 1820 (2007).CrossRefGoogle Scholar
Charest, J.L., Eliason, M.T., García, A.J., King, W.P., Biomaterials 27, 2487 (2006).CrossRefGoogle Scholar
Xia, Y., Whitesides, G.M., Angew. Chem. Int. Ed. 37, 550 (1998).3.0.CO;2-G>CrossRefGoogle Scholar
Lee, C.J., Blumenkranz, M.S., Fishman, H.A., Bent, S.F., Langmuir 20, 4155 (2004).CrossRefGoogle ScholarPubMed
Duffy, D.C., McDonald, J.C., Schueller, J.A., Whitesides, G.M., Anal. Chem. 70, 4974 (1998).CrossRefGoogle Scholar
Engler, A.J., Sen, S., Sweeney, H.L., Discher, D.E., Cell 126, 677 (2006).CrossRefGoogle ScholarPubMed
Bettinger, C.J., Orrick, B., Misra, A., Langer, R., Borenstein, J.T., Biomaterials 27, 2558 (2006).CrossRefGoogle Scholar
Dalby, M.J., Riehle, M.O., Johnstone, H., Affrossman, S., Curtis, A.S.G., Biomaterials 23, 2945 (2002).CrossRefGoogle Scholar
Oakley, C., Brunette, D.M., J. Cell Sci. 106, 343 (1993).CrossRefGoogle Scholar
Abrams, G.A., Goodman, S.L., Nealey, P.F., Franco, M., Murphy, C.J., Cell Tissue Res. 299, 39 (2000).CrossRefGoogle Scholar
García, A.J., Boettiger, D., Biomaterials 20, 2427 (1999).CrossRefGoogle Scholar
Petrie, T.A., Capadona, J.R., Reyes, C.D., García, A.J., Biomaterials 27, 5459 (2006).CrossRefGoogle Scholar
Lo, C.-M., Wang, H.-B., Dembo, M., Wang, Y.-l., Biophys. J. 79, 144 (2000).CrossRefGoogle Scholar
Harrison, R.G., J. Exp. Zool. 9, 787 (1910).CrossRefGoogle Scholar
Clark, P., Connolly, P., Curtis, A., Dow, J., Wilkinson, C.D., J. Cell Sci. 99, 73 (1991).CrossRefGoogle Scholar
Flemming, R.G., Murphy, C.J., Abrams, G.A., Goodman, S.L., Nealey, P.F., Biomaterials 20, 573 (1999).CrossRefGoogle Scholar
Bettinger, C., Langer, R., Borenstein, J., Angew. Chem. 48, 5406 (2009).CrossRefGoogle Scholar
Bernard, A., Renault, J.P., Michel, B., Bosshard, H.R., Delamarche, E., Adv. Mater. 12, 1067 (2000).3.0.CO;2-M>CrossRefGoogle Scholar
Bettinger, C.J., Weinberg, E.J., Kulig, K.M., Vacanti, J.P., Wang, Y., Borenstein, J.T., Langer, R., Adv. Mater. 18, 165 (2006).CrossRefGoogle Scholar
Bettinger, C.J., Kulig, K.M., Vacanti, J.P., Langer, R., Borenstein, J.T., Tissue Eng. 15, 1321 (2009).CrossRefGoogle Scholar
Engelmayr, G.C., Cheng, M., Bettinger, C.J., Borenstein, J.T., Langer, R., Freed, L.E., Nat. Mater. 7, 1003 (2008).CrossRefGoogle Scholar
Choi, C.-H., Hagvall, S.H., Wu, B.M., Dunn, J.C.Y., Beygui, R.E., Kim, C.-J., Biomaterials 28, 1672 (2007).CrossRefGoogle Scholar
Gerecht, S., Bettinger, C.J., Zhang, Z., Borenstein, J., Vunjak-Novakovic, G., Langer, R., Biomaterials 28, 4068 (2007).CrossRefGoogle Scholar
Bettinger, C.J., Zhang, Z., Gerecht, S., Borenstein, J.T., Langer, R., Adv. Mater. 20, 99 (2008).CrossRefGoogle Scholar
Diehl, K.A., Foley, J.D., Nealey, P.F., Murphy, C.J., J. Biomed. Mater. Res. 75A, 603 (2005).CrossRefGoogle Scholar
Dalby, M.J., Gadegaard, N., Tare, R., Andar, A., Riehle, M.O., Herzyk, P., Wilkinson, C.D.W., Oreffo, R.O.C., Nat. Mater. 6, 997 (2007).CrossRefGoogle Scholar
Foley, J.D., Grunwald, E.W., Nealey, P.F., Murphy, C.J., Biomaterials 26, 3639 (2005).CrossRefGoogle Scholar
Patel, S., Kurpinski, K., Quigley, R., Gao, H., Hsiao, B.S., Poo, M.M., Li, S., Nano Lett. 7, 2122 (2007).CrossRefGoogle Scholar
Gardel, M.L., Schneider, I.C., Aratyn-Schaus, Y., Waterman, C.M., Annu. Rev. Cell Dev. Biol. 26, 315 (2010).CrossRefGoogle Scholar
Geiger, R., Taylor, W., Glucksberg, M., Dean, D., Gene Ther. 13, 725 (2006).CrossRefGoogle Scholar
Wang, H., Ip, W., Boissy, R., Grood, E.S., J. Biomechan. 28, 1543 (1995).CrossRefGoogle Scholar
Jungbauer, S., Gao, H., Spatz, J.P., Kemkemer, R., Biophys. J. 95, 3470 (2008).CrossRefGoogle Scholar
Lahann, J., Mitragotri, S., Tran, T.-N., Kaido, H., Sundaram, J., Choi, I.S., Hoffer, S., Somorjai, G.A., Langer, R., Science 299, 371 (2003).CrossRefGoogle Scholar
Jiang, X., Bruzewicz, D.A., Wong, A.P., Piel, M., Whitesides, G.M., Proc. Natl. Acad. Sci. USA 102, 975 (2005).CrossRefGoogle Scholar
Gumus, A., Califano, J.P., Wan, A.M.D., Huynh, J., Reinhart-King, C.A., Malliaras, G.G., Soft Matter 6, 5138 (2010).CrossRefGoogle Scholar
Bettinger, C.J., Bruggeman, J.P., Misra, A., Borenstein, J.T., Langer, R., Biomaterials 30, 3050 (2009).CrossRefGoogle Scholar
Muskovich, M., Bettinger, C.J., Adv. Healthcare Mater. 1, 248 (2012).CrossRefGoogle Scholar
Slater, J.H., Miller, J.S., Yu, S.S., West, J.L., Adv. Funct. Mater. 21, 2876 (2011).CrossRefGoogle Scholar
Lim, H.S., Han, J.T., Kwak, D., Jin, M., Cho, K., J. Am. Chem. Soc. 128, 14458 (2006).CrossRefGoogle Scholar
Dalby, M.J., Riehle, M.O., Sutherland, D.S., Agheli, H., Curtis, A.S.G., Eur. J. Cell Biol. 83, 159 (2004).CrossRefGoogle Scholar
Dalby, M.J., Biggs, M.J.P., Gadegaard, N., Kalna, G., Wilkinson, C.D.W., Curtis, A.S.G., J. Cell. Biochem. 100, 326 (2007).CrossRefGoogle Scholar
Peng, L., Eltgroth, M.L., LaTempa, T.J., Grimes, C.A., Desai, T.A., Biomaterials 30, 1268 (2009).CrossRefGoogle Scholar
Campbell, R.D., Marcum, B.A., J. Cell Sci. 41, 33 (1980).CrossRefGoogle Scholar
Nakatsuji, N., Amer. Zool. 24, 615 (1984).CrossRefGoogle Scholar
Newgreen, D.F., Dev. Biol. 131, 136 (1989).CrossRefGoogle Scholar
Wolf, K., Muller, R., Borgmann, S., Brocker, E.B., Friedl, P., Blood 102, 3262 (2003).CrossRefGoogle Scholar
Weiss, P., J. Exp. Zool. 100, 353 (1945).CrossRefGoogle Scholar
Dunn, G.A., Heath, J.P., Exp. Cell Res. 101, 1 (1976).CrossRefGoogle Scholar
Andersson, A.-S., Olsson, P., Lidberg, U., Sutherland, D., Exp. Cell Res. 288, 177 (2003).CrossRefGoogle Scholar
Rebollar, E., Frischauf, I., Olbrich, M., Peterbauer, T., Hering, S., Preiner, J., Hinterdorfer, P., Romanin, C., Heitz, J., Biomaterials 29, 1796 (2008).CrossRefGoogle Scholar
Lim, J.Y., Donahue, H.J., Tissue Eng. 13, 1879 (2007).CrossRefGoogle Scholar
Lenhert, S., Meier, M.-B., Meyer, U., Chi, L., Wiesmann, H.P., Biomaterials 26, 563 (2005).CrossRefGoogle Scholar
Kaiser, J.-P., Reinmann, A., Bruinink, A., Biomaterials 27, 5230 (2006).CrossRefGoogle Scholar
Tzvetkova-Chevolleau, T., Stéphanou, A., Fuard, D., Ohayon, J., Schiavone, P., Tracqui, P., Biomaterials 29, 1541 (2008).CrossRefGoogle Scholar
Martínez, E., Engel, E., Planell, J.A., Samitier, J., Ann. Anat. 191, 126 (2009).CrossRefGoogle Scholar
Cavalcanti-Adam, E.A., Volberg, T., Micoulet, A., Kessler, H., Geiger, B., Spatz, J.P., Biophys. J. 92, 2964 (2007).CrossRefGoogle Scholar
Chou, L., Firth, J.D., Uitto, V.J., Brunette, D.M., J. Cell Sci. 108, 1563 (1995).CrossRefGoogle Scholar
Nagata, I., Kawana, A., Nakatsuji, N., Development 117, 401 (1993).CrossRefGoogle Scholar
Rosenberg, M.D., Proc. Natl. Acad. Sci. USA 48, 1342 (1962).CrossRefGoogle Scholar
Champion, J.A., Katare, Y.K., Mitragotri, S., J. Control. Release 121, 3 (2007).CrossRefGoogle Scholar
Albrecht-Buehler, G., J. Cell Biol. 69, 275 (1976).CrossRefGoogle Scholar
Carrel, A., Burrows, M.T., J. Exp. Med. 13, 571 (1911).CrossRefGoogle Scholar
Weiss, P., Garber, B., Proc. Natl. Acad. Sci. USA 38, 264 (1952).CrossRefGoogle Scholar
Dalby, M.J., Hart, A., Yarwood, S.J., Biomaterials 29, 282 (2008).CrossRefGoogle Scholar
Johansson, F., Carlberg, P., Danielsen, N., Montelius, L., Kanje, M., Biomaterials 27, 1251 (2006).CrossRefGoogle Scholar
Oakley, C., Brunette, D.M., Cell Motil. Cytoskel. 31, 45 (1995).CrossRefGoogle Scholar
Jiang, X., Takayama, S., Q, X., Ostuni, E., Wu, H., Bowden, N., LeDuc, P., Ingber, D.E., Whitesides, G.M., Langmuir 18, 3273 (2002).CrossRefGoogle Scholar
Tan, J.L., Tien, J., Pirone, D.M., Gray, D.S., Bhadriraju, K., Chen, C.S., Proc. Natl. Acad. Sci. USA 100, 1484 (2003).CrossRefGoogle Scholar
Li, Z., Song, J., Mantini, G., Lu, M.-Y., Fang, H., Falconi, C., Chen, L.-J., Wang, Z.L., Nano Lett. 9, 3575 (2009).CrossRefGoogle Scholar
du Roure, O., Saez, A., Buguin, A., Austin, R.H., Chavrier, P., Siberzan, P., Ladoux, B., Proc. Natl. Acad. Sci. USA 102, 2390 (2005).CrossRefGoogle Scholar
Fu, C.-C., Grimes, A., Long, M., Ferri, C.G.L., Rich, B.D., Ghosh, S., Ghosh, S., Lee, L.P., Gopinathan, A., Khine, M., Adv. Mater. 21, 4472 (2009).CrossRefGoogle Scholar
Chen, A., Lieu, D.K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R.J., Gopinathan, A., Botvinick, E., Fowlkes, C.C., Li, R.A., Khine, M., Adv. Mater. 23, 5785 (2011).CrossRefGoogle Scholar
Davis, K.A., Burke, K.A., Mather, P.T., Henderson, J.H.: Dynamic cell behavior on shape memory polymer substrates. Biomaterials 32, 2285 (2011).CrossRefGoogle ScholarPubMed
Lam, M.T., Clem, W.C., Takayama, S., Biomaterials 29, 1705 (2008).CrossRefGoogle Scholar
Wang, J.H.C., Goldschmidt-Clermont, P., Wille, J., Yin, F.C.P., J. Biomech. 34, 1563 (2001).CrossRefGoogle Scholar
Zhu, X., Mills, K.L., Peters, P.R., Bahng, J.H., Liu, E.H., Shim, J., Naruse, K., Csete, M.E., Thouless, M.D., Takayama, S., Nat. Mater. 4, 403 (2005).CrossRefGoogle Scholar
McBeath, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K., Chen, C.S., Dev. Cell 6, 483 (2004).CrossRefGoogle ScholarPubMed
Suresh, S., Spatz, J., Mills, J.P., Micoulet, A., Dao, M., Lim, C.T., Beil, M., Seufferlein, T., Acta Biomater 1, 15 (2005).CrossRefGoogle Scholar
Suresh, S., Acta Materialia 55, 3989 (2007).CrossRefGoogle Scholar
Cross, S.E., Jin, Y.-S., Rao, J., Gimzewski, J.K., Nat. Nanotechnol. 2, 780 (2007).CrossRefGoogle Scholar
Rosenbluth, M.J., Lam, W.A., Fletcher, D.A., Lab Chip 8, 1062 (2008).CrossRefGoogle Scholar
Ingber, D.E., J. Cell Sci. 104, 613 (1993).CrossRefGoogle Scholar
Ingber, D.E., J. Cell Sci. 116, 1157 (2003).CrossRefGoogle Scholar
Charras, G.T., Horton, M.A., Biophys. J. 82, 2970 (2002).CrossRefGoogle Scholar
Hotani, H., Miyamoto, H., Adv. Biophys. 26, 135 (1990).CrossRefGoogle Scholar
MacKintosh, F.C., Kas, J., Janmey, P.A., Phys. Rev. Lett. 75, 4425 (1995).CrossRefGoogle Scholar
Forgacs, G., J. Cell Sci. 108, 2131 (1995).CrossRefGoogle Scholar
Shafrir, Y., Forgacs, G., Am. J. Physiol. Cell Physiol. 282, C479 (2002).CrossRefGoogle Scholar
Parker, K.K., Brock, A.L., Brangwynne, C., Mannix, R.J., Wang, N., Ostuni, E., Geisse, N.A., Adams, J.C., Whitesides, G.M., Ingber, D.E., FASEB J 16, 1195 (2002).CrossRefGoogle Scholar
Discher, D.E., Janmey, P., Wang, Y.-l., Science 310, 1139 (2005).CrossRefGoogle Scholar
Yeung, T., Georges, P.C., Flanagan, L.A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., Janmey, P.A., Cell Motil. Cytoskel. 60, 24 (2005).CrossRefGoogle Scholar
Cheng, C.-M., Steward, R.L. Jr., LeDuc, P.R., J. Biomech. 42, 187 (2009).CrossRefGoogle Scholar
Gupta, P., Vermani, K., Garg, S., Drug Discov. Today 7, 569 (2002).CrossRefGoogle Scholar
Peppas, N.A., Leobandung, W., Journal of Biomaterials Science, Polymer Edition 15, 125 (2004).CrossRefGoogle Scholar
Bettinger, C.J., Pure Appl. Chem. 83, 9 (2011).CrossRefGoogle Scholar
Kosif, I., Park, E.-J., Sanyal, R., Sanyal, A., Macromolecules 43, 4140 (2010).CrossRefGoogle Scholar
Nimmo, C.M., Owen, S.C., Shoichet, M.S., Biomacromolecules 12, 824 (2011).CrossRefGoogle Scholar
Shi, D., Matsusaki, M., Kaneko, T., Akashi, M., Macromolecules 41, 8167 (2008).CrossRefGoogle Scholar
Pinazzi, P., Fernandez, A., Ultraviolet Light Induced Reactions in Polymers (American Chemical Society, Washington, DC, 1976), p. 37.CrossRefGoogle Scholar
Kloxin, C.J., Scott, T.F., Adzima, B.J., Bowman, C.N., Macromolecules 43, 2643 (2010).CrossRefGoogle Scholar
Fomina, N., McFearin, C.L., Sermsakdi, M., Morachis, J.M., Almutairi, A., Macromolecules 44, 8590 (2011).CrossRefGoogle Scholar
Luo, Y., Shoichet, M.S., Nat. Mater. 3, 249 (2004).CrossRefGoogle Scholar
Wylie, R.G., Shoichet, M.S., J. Mater. Chem. 18, 2716 (2008).CrossRefGoogle Scholar
Kloxin, A.M., Kasko, A.M., Salinas, C.N., Anseth, K.S., Science 324, 59 (2009).CrossRefGoogle Scholar
Kloxin, A.M., Tibbitt, M.W., Anseth, K.S., Nat. Protoc. 5, 1867 (2010).CrossRefGoogle Scholar
Kloxin, A.M., Benton, J.A., Anseth, K.S., Biomaterials 31, 1 (2010).CrossRefGoogle Scholar
Hui, E.E., Bhatia, S.N., Proc. Natl. Acad. Sci. USA 104, 5722 (2007).CrossRefGoogle Scholar