International Psychogeriatrics

Research Article

Cognition, coping, and outcome in Parkinson's disease

Catherine S. Hurta1 c1, Sabine Landaua2, David J. Burna3, John V. Hindlea4, Mike Samuela5, Ken Wilsona6 and Richard G. Browna7 on behalf of the PROMS-PD Study Group

a1 School of Health Sciences, City University London, London, UK

a2 Department of Biostatistics, Institute of Psychiatry, King's College London, London, UK

a3 Clinical Ageing Research Unit, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

a4 Department of Care of the Elderly, Betsi Cadwaladr University Health Board, Llandudno Hospital, Llandudno; and School of Medical Sciences, University of Bangor, Bangor, UK

a5 Department of Neurology, King's College Hospital NHS Foundation Trust, King's Health Partners, London; and Department of Neurology, East Kent Hospitals NHS Trust, Ashford, Kent UK

a6 Emi Academic Unit, St Catherine's Hospital, University of Liverpool, Wirral, UK

a7 Department of Psychology, Institute of Psychiatry, King's College London, London, UK

ABSTRACT

Background: Cognitive impairment and depression are common and disabling non-motor symptoms of Parkinson's disease (PD). Previous studies have shown associations between them but the nature of the relationship remains unclear. In chronic illness, problem- or task-oriented coping strategies are associated with better outcome but often require higher level cognitive functioning. The present study investigated, in a sample of patients with PD, the relationships between cognitive function, choice of coping strategies, and a broad index of outcome including depression, anxiety, and health-related quality of life (QoL). It was hypothesized that the coping strategy used could mediate the association between cognition and outcome.

Methods: 347 participants completed the Coping Inventory for Stressful Situations, the Hospital Anxiety and Depression Scale, the Parkinson's Disease Questionnaire-8, the Unified Parkinson's Disease Rating Scale, and the Addenbrooke's Cognitive Examination–Revised. Structural Equation Modeling was used to test the hypothesized model of cognition, coping, and outcome based on a direct association between cognition and outcome and an indirect association mediated by coping.

Results: Overall, poorer cognition predicted less use of task-oriented coping, which predicted worse outcome (a latent variable comprised of higher depression and anxiety and lower QoL). The analyses suggested a small indirect effect of cognition on outcome mediated by coping.

Conclusions: The findings suggest that patients who fail to employ task-oriented coping strategies may be at greater risk of depression, anxiety, and poor health-related QoL. Even mild to moderate cognitive impairment may contribute to reduced use of task-oriented coping. Suitably adapted cognitive–behavioral approaches may be useful to enable the use of adaptive coping strategies in such patients.

(Received January 24 2012)

(Revised February 27 2012)

(Revised March 26 2012)

(Accepted April 05 2012)

(Online publication May 22 2012)

Correspondence:

c1 Correspondence should be addressed to: Dr. Catherine S. Hurt, Health Services Research, Room 224, College Building, City University London, Northampton Square, London EC1V 0HB, UK. Phone: +44-20-7040-0883; Fax: +44-20-7040-0875. Email: Catherine.hurt.1@city.ac.uk.