International Psychogeriatrics

Research Article

Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study

Jeannie-Marie S. Leoutsakosa1 c1, Dingfen Hana1, Michelle M. Mielkea1, Sarah N. Forrestera1, JoAnn T. Tschanza2a3, Chris D. Corcorana2a4, Robert C. Greena6, Maria C. Nortona2a3a5, Kathleen A. Welsh-Bohmera7 and Constantine G. Lyketsosa1

a1 Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

a2 Center for Epidemiologic Studies, Consumer and Human Development, Utah State University, Logan, Utah, USA

a3 Department of Psychology, Consumer and Human Development, Utah State University, Logan, Utah, USA

a4 Department of Mathematics and Statistics, Consumer and Human Development, Utah State University, Logan, Utah, USA

a5 Department of Family, Consumer, and Human Development, Utah State University, Logan, Utah, USA

a6 Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

a7 Department of Psychiatry and Behavioral Sciences and the Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, North Carolina, USA

ABSTRACT

Background: Several observational studies have suggested a link between health status and rate of decline among individuals with Alzheimer's disease (AD). We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression.

Methods: This was a case-only cohort study arising from a population-based longitudinal study of memory and aging, in Cache County, Utah. Participants comprised 335 individuals with incident AD followed for up to 11 years. Patient descriptors included sex, age, education, dementia duration at baseline, and APOE genotype. Measures of health status made at each visit included the General Medical Health Rating (GMHR), number of comorbid medical conditions, and number of non-psychiatric medications. Dementia outcomes included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating – sum of boxes (CDR-sb), and the Neuropsychiatric Inventory (NPI).

Results: Health status tended to fluctuate over time within individuals. None of the baseline medical variables (GMHR, comorbidities, and non-psychiatric medications) was associated with differences in rates of decline in longitudinal linear mixed effects models. Over time, low GMHR ratings, but not comorbidities or medications, were associated with poorer outcomes (MMSE: β = –1.07 p = 0.01; CDR-sb: β = 1.79 p < 0.001; NPI: β = 4.57 p = 0.01).

Conclusions: Given that time-varying GMHR, but not baseline GMHR, was associated with the outcomes, it seems likely that there is a dynamic relationship between medical and cognitive health. GMHR is a more sensitive measure of health than simple counts of comorbidities or medications. Since health status is a potentially modifiable risk factor, further study is warranted.

(Received January 05 2012)

(Revised January 29 2012)

(Revised February 22 2012)

(Accepted February 23 2012)

(Online publication June 12 2012)

Correspondence:

c1 Correspondence should be addressed to: Dr. Jeannie-Marie S. Leoutsakos, PhD, MHS, Assistant Professor, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview – Alpha Commons Building 4th Floor, Baltimore, MD 21224, USA. Phone: +1 410-550-9884; Fax: +1 410-550-1407. Email: jeannie-marie@jhu.edu.

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