Journal of Fluid Mechanics

Papers

Lagrangian transport properties of pulmonary interfacial flows

Bradford J. Smitha1, Sarah Lukensa2a3, Eiichiro Yamaguchia1 and Donald P. Gaver IIIa1 c1

a1 Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA

a2 Mathematics Department, Tulane University, New Orleans, LA 70118, USA

a3 Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA

Abstract

Disease states characterized by airway fluid occlusion and pulmonary surfactant insufficiency, such as respiratory distress syndrome, have a high mortality rate. Understanding the mechanics of airway reopening, particularly involving surfactant transport, may provide an avenue to increase patient survival via optimized mechanical ventilation waveforms. We model the occluded airway as a liquid-filled rigid tube with the fluid phase displaced by a finger of air that propagates with both mean and sinusoidal velocity components. Finite-time Lyapunov exponent (FTLE) fields are employed to analyse the convective transport characteristics, taking note of Lagrangian coherent structures (LCSs) and their effects on transport. The Lagrangian perspective of these techniques reveals flow characteristics that are not readily apparent by observing Eulerian measures. These analysis techniques are applied to surfactant-free velocity fields determined computationally, with the boundary element method, and measured experimentally with micro particle image velocimetry ($\ensuremath{\mu} $-PIV). We find that the LCS divides the fluid into two regimes, one advected upstream (into the thin residual film) and the other downstream ahead of the advancing bubble. At higher oscillatory frequencies particles originating immediately inside the LCS experience long residence times at the air–liquid interface, which may be conducive to surfactant transport. At high frequencies a well-mixed attractor region is identified; this volume of fluid cyclically travels along the interface and into the bulk fluid. The Lagrangian analysis is applied to velocity data measured with 0.01 mg ml−1 of the clinical pulmonary surfactant Infasurf in the bulk fluid, demonstrating flow field modifications with respect to the surfactant-free system that were not visible in the Eulerian frame.

(Received April 29 2011)

(Reviewed July 22 2011)

(Accepted September 10 2011)

(Online publication November 09 2011)

Key Words:

  • interfacial flows (free surface);
  • pulmonary fluid mechanics

Correspondence:

c1 Email address for correspondence: dpg@tulane.edu

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