a1 Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
a2 DISM, Inter-University Centre for Behavioural Neurosciences, University of Udine, Udine, Italy and Scientific Institute IRCCS ‘E. Medea’, Udine, Italy
a3 Department of Mental Health, 1st Psychiatric Service, ULSS 20, Verona, Italy
a4 Department of Mental Health, ULSS 6, Vicenza, Italy
a5 Department of Mental Health, ULSS 22, Isola d/S, VR, Italy
a6 Department of Mental Health, ULSS 10, Portogruaro, VE, Italy
a7 Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
Aims. This paper aims at providing an overview of the background, design and initial findings of Psychosis Incident Cohort Outcome Study (PICOS).
Methods. PICOS is a large multi-site population-based study on first-episode psychosis (FEP) patients attending public mental health services in the Veneto region (Italy) over a 3-year period. PICOS has a naturalistic longitudinal design and it includes three different modules addressing, respectively, clinical and social variables, genetics and brain imaging. Its primary aims are to characterize FEP patients in terms of clinical, psychological and social presentation, and to investigate the relative weight of clinical, environmental and biological factors (i.e. genetics and brain structure/functioning) in predicting the outcome of FEP.
Results. An in-depth description of the research methodology is given first. Details on recruitment phase and baseline and follow-up evaluations are then provided. Initial findings relating to patients' baseline assessments are also presented. Future planned analyses are outlined.
Conclusions. Both strengths and limitations of PICOS are discussed in the light of issues not addressed in the current literature on FEP. This study aims at making a substantial contribution to research on FEP patients. It is hoped that the research strategies adopted in PICOS will enhance the convergence of methodologies in ongoing and future studies on FEP.
(Received February 28 2012)
(Revised April 04 2012)
(Accepted April 04 2012)
(Online publication June 15 2012)
c1 Address for correspondence: Dr Antonio Lasalvia, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Policlinico ‘G.B. Rossi’, Piazzale L. A. Scuro 10, 37134-Verona, Italy. (Email: [email protected])