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Effects of dietary trans-fatty acids on reproductive performance of Wistar rats

Published online by Cambridge University Press:  09 March 2007

T. Hanis ,
V. Zidek ,
J. Sachova ,
P. Klir  and
Z. Deyl
T. Hanis
Affiliation:
Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
V. Zidek
Affiliation:
Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
J. Sachova
Affiliation:
Research Institute of Animal Production, Prague, Czechoslovakia
P. Klir
Affiliation:
Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
Z. Deyl
Affiliation:
Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
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Abstract

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1. Wistar rats were fed for three successive generations on a semi-purified diet, in which the fat was provided by butter, sunflower oil, rapeseed oil or hydrogenated vegetable fat, differing in the content of cis, cis-18:2 and trans-18:1 fatty acids. Effects of these fats on the composition of adipose tissue and reproductive performance were studied. Fatty acids were analysed using high-performance liquid chromatography.

2. The fatty acid pattern of adipose tissue was closely related to dietary fat composition and, established in the first generation, did not change significantly in successive generations of rats.

3. Hydrogenated fat adversely affected litter size, sperm morphology and regularity of oestrous cycle, and prolonged the period of gestation in experimental animals. Differences observed between the generations were not significant.

4. Hydrogenated fat decreased the level of serum testosterone in males, but the differences observed in levels of serum progesterone in females were not apparently related to the dietary trans-fatty acids.

Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 61 , Issue 3 , May 1989 , pp. 519 - 529
Copyright
Copyright © The Nutrition Society 1989

References

Abraham, G. E. (1974) Radioimmunoassay of steroids in biological materials. Acta Endocrinologica 183, Suppl., 1–42.CrossRefGoogle Scholar
Ahluwalia, B., Pincus, G. & Holman, R. T. (1967) Essential fatty acid deficiency and its effects upon reproductive organs of male rabbits. Journal of Nutrition 92, 205–214.CrossRefGoogle Scholar
Alfin-Slater, R. B. & Aftergood, L. (1979) Nutritional role of hydrogenated fats (in rats). In Geometrical and Positional Fatty Acid Isomers pp. 53–74 [Emken, E.A. and Dutton, H. J., editors]. Champaign, Ill.: American Oil Chemists' Society.Google Scholar
Alfin-Slater, R. B., Morris, R. S., Hansen, H. & Proctor, J. F. (1965) Effects of non-essential fatty acids on essential fatty acid deficiency. Journal of Nutrition 87, 168–172.CrossRefGoogle ScholarPubMed
Alfin-Slater, R. B., Wells, A. F., Aftergood, L. & Deuel, H. J. Jr. (1957) Nutritive value and safety of hydrogenated vegetable fats as evaluated by long-term feeding experiments with rats. Journal of Nutrition 63, 241–261.CrossRefGoogle ScholarPubMed
Alling, C., Bruce, A., Karlsson, I., Sapia, O. & Svennerholm, L. (1972) Effects of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21-day-old-rats. Journal of Nutrition 102, 773–782.CrossRefGoogle ScholarPubMed
American Institute of Nutrition. (1977) Report of the AIN Ad Hoc Committee on standards for nutritional studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Burr, G. O. & Burr, M. M. (1930) On the nature and the role of the fatty acids essential in nutrition. Journal of Biological Chemistry 86, 587–621.CrossRefGoogle Scholar
Cornwell, D. G. & Morisaki, N. (1984) Fatty acid paradoxes in the control of cell proliferation: prostaglandins, lipid peroxides, and cooxidation reactions. In Free Radicals in Biology Vol. 6, pp. 95–148. New York: Academic Press.CrossRefGoogle Scholar
Duthie, I. F. & Barlow, S. M. (1982) A rat life span study comparing partially hydrogenated fish oil, partially hydrogenated soybean oil and rapeseed oil included in the diet at high levels: outline description and interim communication. In Nutritional Evaluation of Long-Chain Fatty Acids in Fish Oil pp. 185–214 [Barlow, M.S. and Stansby, M. E., editors]. London: Academic Press.Google Scholar
Egwim, P. O. & Kummerow, F. A. (1972) Incorporation and distribution of dietary elaidate in the major lipid classes of rat heart and plasma lipoproteins. Journal of Nutrition 102, 783–792.CrossRefGoogle ScholarPubMed
Emken, E. A. (1983) Biochemistry of unsaturated fatty acid isomers. Journal of the American Oil Chemists' Society 60, 995–1004.CrossRefGoogle Scholar
Emken, E. A. (1984) Nutrition and biochemistry of trans and positional fatty acid isomers in hydrogenated oils. Annual Reviews of Nutrition 4, 339–376.CrossRefGoogle ScholarPubMed
Fishman, J., Boyar, R. M. & Hellman, L. (1975) Influence of body weight on estradiol metabolism in young women. Journal of Clinical Endocrinology and Metabolism 41, 989–991.CrossRefGoogle ScholarPubMed
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Frisch, R. E. (1984) Body fat, puberty and fertility. Biological Reviews 59, 161–188.CrossRefGoogle ScholarPubMed
Gorman, R. R. (1979) Modulation of human platelet function by prostacyclin and thromboxane A2. Federation Proceedings 38, 83–88.Google ScholarPubMed
Guesnet, Ph., Pascal, G. & Durand, G. (1986) Dietary α-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. Reproduction, Nutrition, Développement 26, 969–985.CrossRefGoogle ScholarPubMed
Hanis, T., Smrz, M., Klir, P., Macek, K. & Deyl, Z. (1986) Improved separation of C12-C22 fatty acid phenacyl esters by reversed phase column liquid chromatography. Collection of Czechoslovak Chemical Communications 51, 2722–2726.CrossRefGoogle Scholar
Hanis, T., Smrz, M., Klir, P., Macek, K., Klima, J., Base, J. & Deyl, Z. (1988) Determination of fatty acids as phenacyl esters by HPLC in rat adipose tissue and blood vessel wall. Journal of Chromatography 452, 443–457.CrossRefGoogle Scholar
Hansen, H. S. (1986) The essential nature of linoleic acid in mammals. Trends in Biochemical Sciences 11, 263–265.CrossRefGoogle Scholar
Hansen, H. S. & Jensen, B. (1985) Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal permeability barrier. Biochimica et Biophysica Acta 834, 357–363.CrossRefGoogle Scholar
Hill, E. G., Johnson, S. B. & Holman, R. T. (1979) Intensification of essential fatty acid deficiency in the rat by dietary trans-fatty acids. Journal of Nutrition 109, 1759–1766.CrossRefGoogle ScholarPubMed
Holman, R. T. (1964) Nutritional and metabolic interrelationship between fatty acids. Federation Proceedings 23, 1062–1067.Google ScholarPubMed
Holman, R. T. (1968) Essential fatty acid deficiency. In Progress in the Chemistry of Fats and Other Lipids Vol. 9, pp. 279–348 [Holman, R. T., editor]. Oxford: Pergamon Press.Google Scholar
Holman, R. T. (1973) Essential fatty acid deficiency in humans. In Dietary Lipids and Postnatal Development pp. 127–143 [Galli, C., Jacini, G. and Pecile, A., editors]. New York: Raven Press.Google Scholar
Holman, R. T. & Aaes-Jorgensen, E. (1956) Effects of trans fatty acid isomers upon essential fatty acid deficiency in rats. Proceedings of the Society for Experimental Biology and Medicine 93, 175–179.CrossRefGoogle Scholar
Johnston, P. V., Johnston, O. C. & Kummerow, F. A. (1958) Deposition of in tissues and fecal excretion of trans-fatty acids in the rat. Journal of Nutrition 65, 13–21.CrossRefGoogle ScholarPubMed
Kirstein, D., Hoy, C.-E. & Holmer, G. (1983) Effect of dietary fats on the ω6- and ω5-desaturation of fatty acids in rat liver microsomes. British Journal of Nutrition 50, 749–756.CrossRefGoogle Scholar
Kritchevsky, D. (1982) Trans-fatty acid effects in experimental atherosclerosis. Federation Proceedings 41, 2813–2817.Google ScholarPubMed
Kurata, N. & Privett, O. S. (1980) Effects of dietary trans-acids on the biosynthesis of arachidonic acid in rat liver microsomes. Lipids 15, 1029–1036.CrossRefGoogle ScholarPubMed
Lewis, R. A. & Austen, K. F. (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell dependent compounds. Nature 293, 103–108.CrossRefGoogle ScholarPubMed
Mahfouz, M. M., Johnson, S. & Holman, R. T. (1980) The effect of isomeric trans-18:1 acids on the desaturation of palmitic, linoleic and eicosa-8,11,14-trienoic acids by rat liver microscomes. Lipids 15, 100–107.CrossRefGoogle Scholar
Marzouki, Z. M. H. & Coniglio, J. G. (1982) Effect of essential fatty acid deficiency on lipids of rat Sertoli and germinal cells. Biology of Reproduction 27, 312–315.CrossRefGoogle ScholarPubMed
Mead, J. F. (1984) The non-eicosanoid functions of the essential fatty acids. Journal of Lipid Research 25, 1517–1521.CrossRefGoogle ScholarPubMed
Menon, N. K., Moore, C. & Dhopeshwarker, G. A. (1981) Effect of essential fatty acid deficiency on maternal, placental, and fetal rat tissues. Journal of Nutrition 111, 1602–1610.CrossRefGoogle ScholarPubMed
Miller, R. G. (1981) Simultaneous Statistical Inference pp. 1–229. Berlin: Springer Verlag.CrossRefGoogle Scholar
Mohrhauer, H. & Holman, R. T. (1967) Metabolism of linoleic acid in relation to dietary saturated fatty acids in rat. Journal of Nutrition 91, 528–534.CrossRefGoogle Scholar
Moore, C. E., Alfin-Slater, R. B. & Aftergood, L. (1980) Incorporation and disappearance of trans-fatty acids in rat tissues. American Journal of Clinical Nutrition 33, 2318–2323.CrossRefGoogle ScholarPubMed
Nugteren, D. H. (1970) Inhibition of prostaglandin biosynthesis by 8-cis, 12-trans, 14-cis-eicosatrienoic acid and 5-cis, 8-cis, 12-trans, 14-cis-eicosatetraenoic acid. Biochimica et Biophysica Acta 210, 171–176.CrossRefGoogle Scholar
Nugteren, D. H., Christ-Hazelhof, E., van der Beek, A. & Houtsmuller, U. M. T. (1985) Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. Biochimica et Biophysica Acta 834, 429–436.CrossRefGoogle ScholarPubMed
Ohlrogge, J. B., Gulley, R. M. & Emken, E. A. (1982) Occurrence of octadecenoic fatty acid isomers from hydrogenated fats in human tissue lipid classes. Lipids 17, 551–556.CrossRefGoogle ScholarPubMed
Parlanti, I. A. & Orellana, L. C. (1985) The influence of an essential fatty acid deficient-diet on the reproductive performance of female rats. Reproduction, Nutrition, Développement 25, 851–860.CrossRefGoogle ScholarPubMed
Pudelkewicz, C., Seufert, J. & Holman, R. T. (1968) Requirements of the female rat for linoleic and linolenic acids. Journal of Nutrition 94, 138–146.CrossRefGoogle ScholarPubMed
Ravel, D., Chambaz, J., Pepin, D., Manier, M. Ch. & Bereziat, G. (1985) Essential fatty acid interconversion during gestation in the rat. Biochimica et Biophysica Acta 833, 161–164.CrossRefGoogle ScholarPubMed
Satomi, S. & Matsuda, I. (1973) Microsomal desaturation of linoleic into gamma-linoleic acid in livers of fetal, suckling and pregnant rat. Biology of the Neonate 22, 1–8.CrossRefGoogle Scholar
Svaar, H. (1982) The long-term heart lesion phenomenon in animals and humans. In Nutritional Evaluation of Long-Chain Fatty Acids in Fish Oil pp. 163–184 [Barlow, S.M. and Stansby, M. E., editors]. London: Academic Press.Google Scholar
Thomassen, M. S., Rortveit, T., Christiansen, E. N. & Norum, K. (1983) Changes in the content of n-6 fatty acids in liver phospholipids in rats as a consequence of partially hydrogenated dietary oils. British Journal of Nutrition 51, 315–322.CrossRefGoogle Scholar
Walker, B. L. (1983) Fats in nutrition. Canadian Journal of Physiology and Pharmacology 61, 253–259.CrossRefGoogle ScholarPubMed
Waltman, R., Tricomi, V., Shabanah, E. H. & Arenas, R. (1978) Prolongation of rat gestation time by polyunsaturated fatty acids. American Journal of Obstetrics and Gynecology 131, 735–738.CrossRefGoogle Scholar
Washington, W. J., Murthy, R. C., Doye, A., Eugene, K., Brown, D. & Bradley, I. (1983) Induction of morphologically abnormal sperm in rats exposed to o-xylene. Archives of Andrology 11, 233–237.CrossRefGoogle ScholarPubMed
Wilck, B. A. (1982) Dietary hydrogenated fat and lipogenic enzyme activity in rat tissues. M.Sc Thesis, University of Guelph, Guelph, Ontario, CanadaGoogle Scholar
Wood, R. (1979) Distribution of dietary geometrical and positional isomers in brain, heart, kidney, liver, lung, muscle, spleen, adipose and hepatoma. In Geometrical and Positional Fatty Acid Isomers pp. 213–281 [Emken, E.A. and Dutton, H. J., editors]. Champaign, Ill.: American Oil Chemists' Society.Google Scholar
Zevenbergen, J. L., Houstmuller, U. M. T. & Gottenbos, J. J. (1988) Linoleic acid requirement of rats fed trans fatty acids. Lipids 23, 178–186.CrossRefGoogle ScholarPubMed