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The effect of three types of saponin on iron and zinc absorption from a single meal in the rat

Published online by Cambridge University Press:  09 March 2007

Susan Southon ,
A. J. A. Wright ,
K. R. Price ,
S. J. Fairweather-Tait  and
G. R. Fenwick
Susan Southon
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
A. J. A. Wright
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
K. R. Price
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
S. J. Fairweather-Tait
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
G. R. Fenwick
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
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Abstract

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1. Iron and zinc retentions in young male rats, given 3 g starch–sucrose paste containing 120 μg Fe as FeSO4 or 139 μg Zn as ZnC12 (extrinsically labelled with 59Fe or 65Zn) and increasing amounts of Gypsophila saponins, were measured by whole-body counting. The results were compared with whole-body Fe and Zn retention from a meal containing crude or purified saponin fractions. In a separate experiment Fe retention from a meal containing Gypsophila saponins, soyasaponin I, or saponins extracted from lucerne (Medicago sativa) plant tops, was measured in older rats.

2. Results indicated that Fe absorption decreased with increasing concentration of Gypsophila saponins. This was significant at a saponin: Fe molar value of approximately 1, with maximum effect occurring at molar ratios of 4 and above, when Fe absorption was reduced by approximately 17%. Gypsophila saponins had no effect on Zn absorption from a test meal.

3. Fe absorption was similar in groups given purified or crude Gypsophila saponins at the same saponin: mineral molar value of 8, demonstrating that the ‘non-saponin’ fraction of the commercial preparation does not affect the absorption of this mineral.

4. Saponins extracted from lucerne plant tops, fed at a saponin:Fe value of approximately 8, also reduced Fe absorption from a single meal. Fe absorption from a meal containing a similar amount of soyasaponin I was not significantly different from controls.

5. These results indicate that some dietary saponins may reduce Fe absorption and hence have an adverse effect on Fe status in man and simple-stomached animals.

Type
Research Article
Information
British Journal of Nutrition , Volume 59 , Issue 3 , May 1988 , pp. 389 - 396
Copyright
Copyright © The Nutrition Society 1988

References

Alvey, N. G., Banfield, C. F., Baxter, T. I., Gower, J. C., Krznowski, W. J., Lane, P. W., Leech, P. W., Nelder, J. A., Payne, R. W., Phelps, K. M., Rogers, C. E., Ross, G. J. S., Simpson, H. R., Todd, A. D., Tunnicliffe-Wilson, G., Wedderburn, R. W. M., White, R. P. & Wilkinson, G. N. (1977). The GENSTAT Manual. Oxford: Rothamstead Experimental Station, Numerical Algorithm Group Ltd.Google Scholar
Bannerman, R. M., O'Brien, J. R. P. & Witts, L. J. (1962). Blood, 20 (5), 532–546.CrossRefGoogle Scholar
Bondi, A., Birk, Y. & Gestetner, B. (1973). In Chemistry and Biochemistry of Herbage, p. 511 [Butler, I. G. W. and Bailey, R. W., editors]. London: Academic Press.Google Scholar
Cheeke, P. R. (1980). In Leaf Protein Concentrates. pp. 396–414 [Telek, L. and Graham, H. D., editors]. Westport, Connecticut: Avi Publishing Co. Inc.Google Scholar
Fairweather-Tait, S. J. & Wright, A. J. A. (1984). British Journal of Nutrition 51, 185–191.CrossRefGoogle Scholar
Gestetner, B. (1971). Phytochemistry 10, 2221–2225.CrossRefGoogle Scholar
Gohtani, S., Ohsuka, Y. & Yamano, Y. (1985). Nippon Nogeikagaku Kaishi 59, 25–30.CrossRefGoogle Scholar
Heth, D. A. & Hoekstra, W. G. (1965). Journal of Nutrition 85, 367–374.CrossRefGoogle Scholar
Ireland, P. A. & Dziedzic, S. Z. (1987). Food Chemistry 23, 105–116.CrossRefGoogle Scholar
Johnson, I. T., Gee, J. M., Price, K. R., Curl, C. L. & Fenwick, G. R. (1986). Journal of Nutrition 116, 2270–2277.CrossRefGoogle Scholar
Kitagawa, I. (1984). Isolation of soya saponins, German Patent no. DE 3400258 Al.Google Scholar
Malinow, M. R., McLaughlin, P. & Safford, C. (1980). Experientia 36, 562–563.CrossRefGoogle Scholar
Morck, T. A., Lynch, S. R. & Coo, J. D. (1983). American Journal of Clinical Nutrition 37 (3), 416–420.CrossRefGoogle Scholar
Nonaka, M. (1986). Phytochemistry 25, 73–79.CrossRefGoogle Scholar
Ota, T., Hasegawa, T. & Suzuki, T. (1986). Nippon Nogeikagaku Kaishi 60, 837–839.CrossRefGoogle Scholar
Price, K. R., Curl, C. L. & Fenwick, G. R. (1986). Journal of the Science of Food and Agriculture 37, 1185–1191.CrossRefGoogle Scholar
Price, K. R., Johnson, I. T. & Fenwick, G. R. (1987). CRC Critical Reviews in Food Science and Nutrition 26, 27–135.CrossRefGoogle Scholar
Sidhu, G. S., Upson, B. & Malinow, M. R. (1987). Nutrition Reports International 35, 615–623.Google Scholar
Sonnenborn, U. (1987). Deutsche Apotheka Zeitung 127, 433–441.Google Scholar
Southon, S., Johnson, I. T., Gee, J. M. & Price, K. R. (1988). British Journal of Nutrition 59, 49–55.CrossRefGoogle Scholar