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Liver enzymes and blood metabolites in a population of free-ranging red deer (Cervus elaphus) naturally infected with Fascioloides magna

Published online by Cambridge University Press:  31 May 2011

K. Severin ,
T. Mašek ,
Z. Janicki ,
D. Konjević ,
A. Slavica ,
A. Marinculić ,
F. Martinković ,
G. Vengušt  and
P. Džaja
K. Severin*
Affiliation:
Department of Forensic and Juridical Veterinary Medicine, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
T. Mašek
Affiliation:
Department of Animal Nutrition, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
Z. Janicki
Affiliation:
Department for Game Biology, Pathology and Breeding, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
D. Konjević
Affiliation:
Department for Game Biology, Pathology and Breeding, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
A. Slavica
Affiliation:
Department for Game Biology, Pathology and Breeding, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
A. Marinculić
Affiliation:
Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
F. Martinković
Affiliation:
Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
G. Vengušt
Affiliation:
Institute for Breeding and Health Care of Game, Fish and Bees, Veterinary Faculty University of Ljubljana, Gerbiceva 60, 1115Ljubljana, Slovenia
P. Džaja
Affiliation:
Department of Forensic and Juridical Veterinary Medicine, Veterinary Faculty University of Zagreb, Heinzelova 55, 10000Zagreb, Croatia
*
*Fax: +385 1 2390125 E-mail: severin@vef.hr
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Abstract

We investigated the effects of Fascioloides magna infection on the serum biochemistry values of the naturally infected red deer population in eastern Croatia. The investigation was performed on 47 red deer with F. magna infection confirmed patho-anatomically in 27 animals (57.4%). Fibrous capsules and migratory lesions were found in 14 deer while only fibrous capsules without migratory lesions were found in 13 deer. In 13 deer both immature and mature flukes were found, in 5 deer only immature flukes were found and in 9 deer only mature flukes were found. Fascioloides magna infected deer with fibrous capsules and migratory lesions had significantly higher values for lactate dehydrogenase (LDH), glutamate dehydrogenase (GLDH) and globulin, and lower values for albumin/globulin ratio and glucose compared to uninfected deer. Fascioloides magna infected deer with fibrous capsules without the presence of migratory lesions had higher values for alanine aminotransferase (ALT) and globulin, and lower values for albumin/globulin ratio and glucose, than the uninfected deer. The number of immature flukes was positively correlated with values of aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), LDH, GLDH, urea and triglycerides. The number of migratory lesions was positively correlated with GGT, GLDH, globulin and urea values. The creatinine value was positively correlated with the number of mature flukes. The trial showed that F. magna infection causes significant changes in serum biochemistry. Moreover, these changes do not completely resemble changes following F. hepatica infection. Further investigation of changes in liver enzymes and other serum metabolites in controlled, experimentally induced fascioloidosis in red deer is needed to better understand the pathogenesis of F. magna.

Type
Research Papers
Information
Journal of Helminthology , Volume 86 , Issue 2 , June 2012 , pp. 190 - 196
Copyright
Copyright © Cambridge University Press 2011

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