Psychological Medicine

Original Articles

Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins

N. K. Hansella1 c1, M. J. Wrighta1, S. E. Medlanda1, T. A. Davenporta2, N. R. Wraya1, N. G. Martina1 and I. B. Hickiea2

a1 Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia

a2 Brain and Mind Research Institute, University of Sydney, Sydney, Australia

Abstract

Background Genetic studies in adults indicate that genes influencing the personality trait of neuroticism account for substantial genetic variance in anxiety and depression and in somatic health. Here, we examine for the first time the factors underlying the relationship between neuroticism and anxiety/depressive and somatic symptoms during adolescence.

Method The Somatic and Psychological Health Report (SPHERE) assessed symptoms of anxiety/depression (PSYCH-14) and somatic distress (SOMA-10) in 2459 adolescent and young adult twins [1168 complete pairs (35.4% monozygotic, 53% female)] aged 12–25 years (mean=15.5±2.9). Differences between boys and girls across adolescence were explored for neuroticism, SPHERE-34, and the subscales PSYCH-14 and SOMA-10. Trivariate analyses partitioned sources of covariance in neuroticism, PSYCH-14 and SOMA-10.

Results Girls scored higher than boys on both neuroticism and SPHERE, with SPHERE scores for girls increasing slightly over time, whereas scores for boys decreased or were unchanged. Neuroticism and SPHERE scores were strongly influenced by genetic factors [heritability (h2)=40–52%]. A common genetic source influenced neuroticism, PSYCH-14 and SOMA-10 (impacting PSYCH-14 more than SOMA-10). A further genetic source, independent of neuroticism, accounted for covariation specific to PSYCH-14 and SOMA-10. Environmental influences were largely specific to each measure.

Conclusions In adolescence, genetic risk factors indexed by neuroticism contribute substantially to anxiety/depression and, to a lesser extent, perceived somatic health. Additional genetic covariation between anxiety/depressive and somatic symptoms, independent of neuroticism, had greatest influence on somatic distress, where it was equal in influence to the factor shared with neuroticism.

(Received July 26 2011)

(Revised September 21 2011)

(Accepted September 26 2011)

(Online publication November 04 2011)

Correspondence

c1 Address for correspondence: Dr N. K. Hansell, Genetic Epidemiology, Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Queensland, Australia 4029. (Email: Narelle.Hansell@qimr.edu.au)

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