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Affective and physiological responses to stress in girls at elevated risk for depression

Published online by Cambridge University Press:  17 April 2012

Christian E. Waugh*
Affiliation:
Stanford University
Luma Muhtadie
Affiliation:
Stanford University
Renee J. Thompson
Affiliation:
Stanford University
Jutta Joormann
Affiliation:
University of Miami
Ian H. Gotlib
Affiliation:
Stanford University
*
Address correspondence and reprint requests to: Christian E. Waugh, Department of Psychology, P.O. Box 7778, Wake Forest University, Winston Salem, NC 27109; E-mail: waughce@wfu.edu.

Abstract

Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2012

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References

Abramson, L. Y., Seligman, M. E. P., & Teasdale, J. D. (1978). Learned helpless in humans: Critique and reformulation. Journal of Abnormal Psychology, 87, 4974.Google Scholar
Ashman, S. B., Dawson, G., & Panagiotides, H. (2008). Trajectories of maternal depression over 7 years: Relations with child psychophysiology and behavior and role of contextual risks. Development and Psychopathology, 20, 5577.CrossRefGoogle ScholarPubMed
Ashman, S. B., Dawson, G., Panagiotides, H., Yamada, E., & Wilkinson, C. W. (2002). Stress hormone levels of children of depressed mothers. Development and Psychopathology, 14, 333349.CrossRefGoogle ScholarPubMed
Barnett, P. A., & Gotlib, I. H. (1988). Psychosocial functioning and depression: Distinguishing among antecedents, concomitants, and consequences. Psychological Bulletin, 104, 97126.CrossRefGoogle ScholarPubMed
Beck, A. T. (1967). Depression: Causes and treatment. Philadelphia, PA: University of Pennsylvania Press.Google Scholar
Beck, A. T. (1976). Cognitive therapy and the emotional disorders. New York: New American Library.Google Scholar
Berntson, G. G., Bigger, J. T. Jr., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., et al. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34, 623648.CrossRefGoogle ScholarPubMed
Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., et al. (1997). The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 545553.CrossRefGoogle ScholarPubMed
Brown, J., Cohen, P., Johnson, J. G., & Smailes, E. M. (1999). Childhood abuse and neglect: Specificity of effect on adolescent and young depression and suicidality. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 14901496.CrossRefGoogle Scholar
Bryk, A., & Raudenbush, S. (1992). Hierarchical linear models: Applications and data analysis methods. Newbury Park, NJ: Sage.Google Scholar
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005). Depression and cortisol responses to psychological stress: A meta-analysis. Psychoneuroendocrinology, 30, 846856.CrossRefGoogle ScholarPubMed
Chida, Y., & Hamer, M. (2008). Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: A quantitative review of 30 years of investigations. Psychological Bulletin, 134, 829885.CrossRefGoogle ScholarPubMed
Conley, C. S., & Rudolph, K. D. (2009). The emerging sex difference in adolescent depression: Interacting contributions of puberty and peer stress. Development and Psychopathology, 21, 593620.CrossRefGoogle ScholarPubMed
Davies, P. T., & Windle, M. (1997). Gender-specific pathways between maternal depressive symptoms, family discord, and adolescent adjustment. Developmental Psychology, 33, 657668.CrossRefGoogle ScholarPubMed
Dearing, K. F., & Gotlib, I. H. (2009). Interpretation of ambiguous information in girls at risk for depression. Journal of Abnormal Child Psychology, 37, 7991.Google Scholar
Dienstbier, R. A. (1989). Arousal and physiological toughness: Implications for mental and physical health. Psychological Review, 96, 84100.Google Scholar
Ewart, C. K., Jorgensen, R. S., & Kolodner, K. B. (1998). Sociotropic cognition moderates blood pressure response to interpersonal stress in high-risk adolescent girls. International Journal of Psychophysiology, 28, 131142.CrossRefGoogle ScholarPubMed
Ewart, C. K., Jorgensen, R. S., Suchday, S., Chen, E., & Matthews, K. A. (2002). Measuring stress resilience and coping in vulnerable youth: The social competence interview. Psychological Assessment, 14, 339352.Google Scholar
First, M. B., Gibbon, M., Spitzer, R. L., & Williams, J. B. W. (1995). User's guide for the Structured Clinical Interview for DSM-IV Axis I disorders (version 2.0). Unpublished manuscript.Google Scholar
Foa, E. B., & Kozak, M. J. (1986). Emotional processing of fear: Exposure to corrective information. Psychological Bulletin, 99, 2035.Google Scholar
Folkman, S., & Moskowitz, J. T. (2000). Positive affect and the other side of coping. American Psychologist, 55, 647654.CrossRefGoogle ScholarPubMed
Fredrickson, B. L., Mancuso, R. A., Branigan, C., & Tugade, M. M. (2000). The undoing effect of positive emotions. Motivation and Emotion, 24, 237258.CrossRefGoogle ScholarPubMed
Fredrickson, B. L., Tugade, M. M., Waugh, C. E., & Larkin, G. R. (2003). What good are positive emotions in crisis? A prospective study of resilience and emotions following the terrorist attacks on the United States on September 11th, 2001. Journal of Personality and Social Psychology, 84, 365376.CrossRefGoogle Scholar
Goodman, S. H., & Gotlib, I. H. (1999). Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychological Review, 106, 458490.CrossRefGoogle ScholarPubMed
Goodman, S. H., & Gotlib, I. H. (2002). Transmission of risk to children of depressed parents: Integration and conclusions. In Goodman, S. H. & Gotlib, I. H. (Eds.), Children of depressed parents: Mechanisms of risk and implications for treatment (pp. 307326). Washington, DC: American Psychological Association.CrossRefGoogle Scholar
Gotlib, I. H., & Goodman, S. H. (1999). Children of parents with depression. In Silverman, W. K. & Ollendick, T. H. (Eds.), Developmental issues in the clinical treatment of children (pp. 415432). Needham Heights, MA: Allyn & Bacon.Google Scholar
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847851.CrossRefGoogle ScholarPubMed
Halligan, S. L., Herbert, J., Goodyer, I., & Murray, L. (2007). Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents. Biological Psychiatry, 62, 4046.CrossRefGoogle ScholarPubMed
Halligan, S. L., Herbert, J., Goodyer, I. M., & Murray, L. (2004). Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biological Psychiatry, 55, 376381.CrossRefGoogle ScholarPubMed
Hammen, C. L. (2009). Children of depressed parents. In Gotlib, I. H. & Hammen, C. L. (Eds.), Handbook of depression (2nd ed., pp. 275297). New York: Guilford Press.Google Scholar
Joormann, J., Eugene, F., & Gotlib, I. H. (2008). Parental depression: Impact on offspring and mechanisms underlying transmission of risk. In Nolen-Hoeksema, S. (Ed.), Handbook of adolescent depression. New York: Guilford Press.Google Scholar
Joormann, J., Talbot, L., & Gotlib, I. H. (2007). Biased processing of emotional information in girls at risk for depression. Journal of Abnormal Psychology, 116, 135143.CrossRefGoogle ScholarPubMed
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980988.CrossRefGoogle ScholarPubMed
Kessler, R. C. (2009). The epidemiology of depression. In Gotlib, I. H. & Hammen, C. L. (Eds.), Handbook of depression (2nd ed., pp. 522). New York: Guilford Press.Google Scholar
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (1993). The “Trier Social Stress Test”: A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28, 7681.CrossRefGoogle Scholar
Kovacs, M. (1985). The children's depression inventory. Psychopharmacology Bulletin, 21, 995998.Google ScholarPubMed
Kristjansson, S. D., Kircher, J. C., & Webb, A. K. (2007). Multilevel models for repeated measures research designs in psychophysiology: An introduction to growth curve modeling. Psychophysiology, 44, 728736.Google Scholar
Lauer, M. S., & Froelicher, V. (2002). Abnormal heart-rate recovery after exercise. Lancet, 360, 11761177.CrossRefGoogle ScholarPubMed
Laurent, J., Schmidt, N. B., Catanzaro, S. J., Joiner, T. E., & Kelley, A. M. (1998). Factor structure of a measure of anxiety sensitivity in children. Journal of Anxiety Disorders, 12, 307331.CrossRefGoogle ScholarPubMed
Lieb, R., Isensee, B., Hofler, M., Pfister, H., & Wittchen, H.-U. (2002). Parental major depression and the risk of depression and other mental disorders in offspring. Archives of General Psychiatry, 59, 365374.Google Scholar
Lieberman, M. D., Eisenberg, N. I., Crockett, M. J., Tom, S. M., Pfeifer, J. H., & Way, B. M. (2007). Putting feelings into words: Affect labeling disrupts amygdala activity in response to affective stimuli. Psychological Science, 18, 421428.CrossRefGoogle ScholarPubMed
Llabre, M. M., Spitzer, S. B., Saab, P. G., & Schneiderman, N. (2001). Piecewise latent growth curve modeling of systolic blood pressure reactivity and recovery from the cold pressor test. Psychophysiology, 38, 951960.CrossRefGoogle ScholarPubMed
Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009). Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology, 34, 12721283.Google Scholar
Mannie, Z. N., Harmer, C. J., & Cowen, P. J. (2007). Increased waking salivary cortisol levels in young people at familial risk of depression. American Journal of Psychiatry, 164, 617621.CrossRefGoogle ScholarPubMed
Mauss, I. B., Levenson, R. W., McCarter, L., Wilhelm, F. H., & Gross, J. J. (2005). The tie that binds? Coherence among emotion experience, behavior, and physiology. Emotion, 5, 175190.Google Scholar
McEwen, B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 3344.Google Scholar
Miranda, J., Persons, J. B., & Byers, C. N. (1990). Endorsement of dysfunctional beliefs depend on current mood state. Journal of Abnormal Psychology, 99, 237241.Google Scholar
Monroe, S. M., & Simons, A. D. (1991). Diathesis–stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406425.CrossRefGoogle ScholarPubMed
Mykletun, A., Bjerkeset, O., Overland, S., Prince, M., Dewey, M., & Stewart, R. (2009). Levels of anxiety and depression as predictors of mortality: The HUNT study. British Journal of Psychiatry, 195, 118125.CrossRefGoogle ScholarPubMed
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2004). Prospective investigation of stress inoculation in young monkeys. Archives of General Psychiatry, 61, 933941.CrossRefGoogle ScholarPubMed
Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003). Neuroendocrine aspects of hypercortisolism in major depression. Hormones & Behavior, 43, 6066.CrossRefGoogle ScholarPubMed
Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916931.CrossRefGoogle ScholarPubMed
Rao, U., Hammen, C. L., Ortiz, L. R., Chen, L., & Poland, R. E. (2008). Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biological Psychiatry, 64, 521526.Google Scholar
Raudenbush, S., Bryk, A., & Congdon, R. (2008). HLM6 [Computer software]. Chicago: Scientific Software International.Google Scholar
Roberts, J. E., & Kassel, J. D. (1996). Mood-state dependence in cognitive vulnerability to depression: The roles of positive and negative affect. Cognitive Therapy and Research, 20, 112.Google Scholar
Salomon, K., Clift, A., Karlsdottir, M., & Rottenberg, J. (2009). Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease. Health Psychology, 28, 157165.Google Scholar
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Review, 21, 5589.Google ScholarPubMed
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001). Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proceedings of the National Academy of Sciences of the United States of America, 98, 47704775.CrossRefGoogle ScholarPubMed
Stewart, W., Ricci, J., Chee, E., Hahn, S., & Morganstein, D. (2003). Cost of lost productive work time among US workers with depression. Journal of American Medical Association, 289, 31353144.Google Scholar
Taylor, L., & Ingram, R. E. (1999). Cognitive reactivity and depressotypic information processing in children of depressed mothers. Journal of Abnormal Psychology, 108, 202210.CrossRefGoogle ScholarPubMed
Taylor, S. F., Phan, K. L., Decker, L. R., & Liberzon, I. (2003). Subjective rating of emotionally salient stimuli modulates neural activity. NeuroImage, 18, 650659.CrossRefGoogle ScholarPubMed
Thompson, R. F., & Spencer, W. A. (1966). Habituation: A model phenomenon for the study of neuronal substrates of behavior. Psychological Review, 73, 1643.CrossRefGoogle Scholar
Tugade, M. M., & Fredrickson, B. L. (2004). Resilient individuals use positive emotions to bounce back from negative emotional experiences. Journal of Personality and Social Psychology, 86, 320333.Google Scholar
Tukey, J. (1977). Exploratory data analysis. Reading, MA: Addison–Wesley.Google Scholar
Turner, S. M., Beidel, D. C., & Roberson-Nay, R. (2005). Offspring of anxious parents: Reactivity, habituation, and anxiety-proneness. Behaviour Research & Therapy, 43, 12631279.Google Scholar
Waugh, C. E., Panage, S., Mendes, W. B., & Gotlib, I. H. (2010). Cardiovascular and affective recovery from anticipatory threat. Biological Psychology, 84, 169175.Google Scholar
Weissman, M. M., Warner, V., Wickramaratne, P., Moreau, D., & Olfson, M. (1997). Offspring of depressed parents: 10 years later. Archives of General Psychiatry, 54, 932940.CrossRefGoogle ScholarPubMed
Young, E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil, H. (2000). Hormonal evidence for altered responsiveness to social stress in major depression. Neuropsychopharmacology, 23, 411418.Google Scholar