Journal of Radiotherapy in Practice

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Original Article

Management of neuroendocrine small cell carcinoma of cervix-a single centre retrospective study

Ursula Mcgiverna1 c1, Jacqueline Clarkea1, Anne Drakea1, Glenn McGluggagea1 and Jonathan McAleesea1

a1 Belfast City Hospital, Belfast, United Kingdom

Abstract

Purpose: To determine disease-free and overall survival of neuroendocrine small cell cancer of cervix treated at the Northern Ireland Cancer centre between 1999 and 2010.

Materials and methods: A retrospective review of all patients diagnosed and treated with neuroendocrine small cell cancer of cervix in Northern Ireland. Details of treatment modality including chemotherapy, radiotherapy and surgery were recorded.

Results: Fifteen patients diagnosed with neuroendocrine small cell carcinoma (NSCC) of cervix were identified between 1999 and 2010, twelve with disease localised to the pelvis and three with metastatic disease. Three-year overall survival for all patients was 65% and disease-free survival was 45% for all patients. In patients with pelvic confined disease 3-year overall survival was 79% and disease-free survival was 57%. Median disease-free and overall survival was 30 and 39.6 months respectively. These survival rates compare very favourably to those reported in the literature. Stage of disease at diagnosis was the main determinant of survival.

Conclusion: Local control and survival can be achieved in NSCC of patients with a combination of irradiation and platinum-based chemotherapy. Stage of disease determines outcomes.

(Received October 10 2011)

(Revised December 05 2011)

(Accepted December 10 2011)

Keywords

Correspondence:

c1 Correspondence to: Ursula Mcgivern, Belfast City Hospital, Belfast, United Kingdom. E-mail: ursulamcgivern@doctors.org.uk

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