Public Health Nutrition

Nutrition and health

Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies

Jusheng Zhenga1, Tao Huanga1, Yinghua Yua1a2, Xiaojie Hua1, Bin Yanga1 and Duo Lia1a3 c1

a1 Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, People's Republic of China

a2 School of Health Sciences, University of Wollongong, Wollongong, New South Wales, Australia

a3 APCNS Centre of Nutrition and Food Safety, Hangzhou, People's Republic of China


Objective Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects.

Design A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity.

Setting PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study.

Subjects Seventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified.

Results Compared with the lowest fish intake (<1 serving/month or 1–3 servings/month), the pooled relative risk (RR) of fish intake on CHD mortality was 0·84 (95 % CI 0·75, 0·95) for low fish intake (1 serving/week), 0·79 (95 % CI 0·67, 0·92) for moderate fish intake (2–4 servings/week) and 0·83 (95 % CI 0·68, 1·01) for high fish intake (>5 servings/week). The dose–response analysis indicated that every 15 g/d increment of fish intake decreased the risk of CHD mortality by 6 % (RR = 0·94; 95 % CI 0·90, 0·98). The method of dietary assessment, gender and energy adjustment affected the results remarkably.

Conclusions Our results indicate that either low (1 serving/week) or moderate fish consumption (2–4 servings/week) has a significantly beneficial effect on the prevention of CHD mortality. High fish consumption (>5 servings/week) possesses only a marginally protective effect on CHD mortality, possibly due to the limited studies included in this group.

(Received October 19 2010)

(Accepted July 29 2011)

(Online publication September 14 2011)


c1 Corresponding author: Email