Epidemiology and Infection

Gastrointestinal infection

The role of drinking water in the transmission of antimicrobial-resistant E. coli

B. L. COLEMANa1a2 c1, M. I. SALVADORIa3a4, A. J. McGEERa1a2, K. A. SIBLEYa5, N. F. NEUMANNa6a7, S. J. BONDYa2, I. A. GUTMANISa4a8, S. A. McEWENa9, M. LAVOIEa7, D. STRONGa7, I. JOHNSONa2a10, F. B. JAMIESONa1a2a10, M. LOUIEa5a7 and ARO Water Study Group

a1 Mount Sinai Hospital, Toronto, ON, Canada

a2 University of Toronto, Toronto, ON, Canada

a3 Children's Hospital of Western Ontario, London, ON, Canada

a4 The University of Western Ontario, London, ON, Canada

a5 University of Calgary, Calgary, AB, Canada

a6 University of Alberta, Edmonton, AB, Canada

a7 Alberta Health Services, Edmonton, AB, Canada

a8 St Joseph's Health Care, London, ON, Canada

a9 University of Guelph, Guelph, ON, Canada

a10 Ontario Agency for Health Protection and Promotion, Toronto, ON, Canada

SUMMARY

To determine whether drinking water contaminated with antimicrobial-resistant E. coli is associated with the carriage of resistant E. coli, selected households sending water samples to Ontario and Alberta laboratories in 2005–2006 were asked to participate in a cross-sectional study. Household members aged ≥12 years were asked to complete a questionnaire and to submit a rectal swab. In 878 individuals, 41% carried a resistant strain of E. coli and 28% carried a multidrug-resistant strain. The risk of carriage of resistant E. coli was 1·26 times higher for users of water contaminated with resistant E. coli. Other risk factors included international travel [prevalence ratio (PR) 1·33], having a child in nappies (PR 1·33), being male (PR 1·33), and frequent handling of raw red meats (PR 1·10). Protecting private water sources (e.g. by improving systems to test and treat them) may help slow the emergence of antimicrobial resistance in E. coli.

(Accepted May 11 2011)

(Online publication June 23 2011)

Correspondence:

c1 Author for correspondence: Dr B. L. Coleman, Mount Sinai Hospital, 600 University Avenue, Room 210, Toronto, Ontario M5G 1X5, Canada. (Email: bcoleman@mtsinai.on.ca)

Footnotes

† The ARO Water Study Group are listed in the Appendix.

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