Hostname: page-component-7c8c6479df-995ml Total loading time: 0 Render date: 2024-03-29T12:55:23.546Z Has data issue: false hasContentIssue false

Metabolic programming of obesity in utero: is there sufficient evidence to explain increased obesity rates?

Published online by Cambridge University Press:  28 November 2011

J. Josefson, MD*
Affiliation:
Assistant Professor, Department of Pediatrics, Division of Endocrinology, Children's Memorial Hospital/Division of Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
*
*Address for correspondence: Dr J. Josefson, MD, Assistant Professor of Pediatrics, Division of Endocrinology, Children's Memorial Hospital/Division of Endocrinology, Northwestern University Feinberg School of Medicine, 2300 Children's Plaza, Box 54, Chicago, Illinois, USA. (Email J-Josefson@northwestern.edu)
Rights & Permissions [Opens in a new window]

Abstract

Type
Editorial
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012

Introduction

As the childhood obesity epidemic continues unabated, research underlying its cause is necessary to curtail its progression. The rate of obesity in middle-class preschool-age children has substantially increased over the past 22 years.Reference Kim, Peterson and Scanlon 1 Recent longitudinal studies indicate that once children of preschool age are obese, the risk of remaining obese in adulthood is doubled.Reference Guo, Wu, Chumlea and Roche 2 Accordingly, researchers have theorized that intervention to prevent obesity must occur early in life.Reference Oken 3 , Reference Rogers 4 Such an intervention requires identifying infants at risk for obesity before these children become overweight. This presents the question of how to identify early predictors of obesity and infants ‘at risk.’

Birth weight has been extensively studied to determine its relationship with obesity risk. Both low birth weight and high birth weight neonates appear to have increased risk of obesity, possibly with similar underlying mechanisms. However, as demonstrated in epidemiologic studies in several countries, most obese children had a normal birth weight.Reference Hirschler, Bugna, Roque, Gilligan and Gonzalez 5 , Reference Dubois and Girard 6 Other factors during the perinatal period that have been associated with increased childhood obesity risk include: gestational diabetes mellitus,Reference Silverman, Rizzo, Cho and Metzger 7 , Reference Pettitt, Knowler, Bennett, Aleck and Baird 8 maternal pre-pregnancy obesityReference Catalano, Farrell and Thomas 9 Reference Boney, Verma, Tucker and Vohr 11 and excessive gestational weight gain (GWG).Reference Olson, Strawderman and Dennison 12 Reference Oken, Rifas-Shiman, Field, Frazier and Gillman 15 This active area of research, termed as metabolic programming, is based on the hypothesis that obesity may have its origins in utero. However, to date, definitive evidence for metabolic programming as a cause for the increase in obesity rates is lacking.

Low birth weight and obesity risk

Barker'sReference Barker 16 developmental origins of health and disease hypothesis was based on observations in England that death due to cardiovascular disease was inversely related to birth weight. Barker postulated that in poor socioeconomic areas where the infant mortality rate had previously been high, as conditions improved, low birth weight infants survived but had increased rates of cardiovascular disease. This novel theory led others to speculate a ‘thrifty phenotype’ in which babies born with a low birth weight because of poor nutrition during pregnancy are programmed to stockpile nutrients.Reference Hales and Barker 17 Retrospective studies of males exposed to the Dutch famine between 1944 and 1945 during early fetal development had increased weight at age 18, whereas males exposed to the famine in later pregnancy or in the neonatal period were not overweight at age 18.Reference Ravelli, Stein and Susser 18 The timing of exposure to nutritional deprivation appears to be critical to metabolic programming. Development in an undernourished uterine environment may program fetuses for an environment of ‘thrift’. However, once placed in a postnatal environment with increased food availability, these children have a propensity to develop obesity and coronary artery disease. Further research conducted in poor areas of India extends the developmental origins hypothesis to fetal programming for the development of type 2 diabetes.Reference Yajnik and Deshmukh 19 However, in more developed countries, babies with low birth weight represent just a small proportion of those children who go on to develop obesity and its metabolic sequelae.

High birth weight and obesity risk

At the other end of the spectrum are babies born large for gestational age, typically defined by birth weights greater than the 90th percentile for gestational age. As reviewed by Whitaker and Dietz,Reference Whitaker and Dietz 20 multiple studies have demonstrated that large babies have increased rates of obesity. Evidence that metabolic programming occurs in a uterine environment of ‘overnutrition’ is provided by studies of mothers with gestational diabetes mellitus. More than half a century ago, PedersenReference Pedersen 21 observed that the excess glucose produced by mothers with diabetes crossed the placenta and acted as a growth factor to induce higher birth weight in these neonates. FreinkelReference Freinkel 22 further expanded Pedersen's observations and developed the theory of fuel-mediated teratogenesis in which other fuels such as free fatty acids, ketone bodies and amino acids, in addition to insulin, lead to excess fetal growth. Long-term follow-up studies of offspring of women with pre-gestational and gestational diabetes have demonstrated these children to have increased rates of obesity,Reference Pettitt, Knowler, Bennett, Aleck and Baird 8 , Reference Silverman, Landsberg and Metzger 23 despite a normal birth weight. These studies indicate that large birth weight is neither necessary nor sufficient to predict later obesity. The increased risk for obesity in babies of diabetic mothers is thought to be due to hyperinsulinism and excessive adiposity at birth. However, because of difficulties in obtaining accurate body composition measurements, little data exist on the relationship between newborn adiposity and childhood adiposity.

Contribution of maternal factors to offspring obesity risk

Maternal obesity is clearly linked to offspring obesity,Reference Lake, Power and Cole 24 and it is one of the most important risk factors for childhood obesity. However, the influence of intrauterine environment of maternal obesity v. the postnatal environment of diet quality and quantity, as well as which influences predominate has not been resolved. Although risk of obesity is highly familial, genetics alone cannot account for the substantial increases in obesity rates over the span of 30 years. Metabolic programming from maternal obesity is evidenced by studies of sibling pairs. Kral et al. Reference Kral, Biron and Simard 25 showed that offspring born to formerly obese women who had lost substantial weight following gastric bypass surgery exhibited significantly lower rates of obesity compared with older siblings born before their mother's surgery and weight loss. Studies of PIMA Indian sibling pairs showed higher childhood obesity rates among children who were born to mothers with diabetes than their older siblings whose mothers did not have diabetes during those earlier pregnancies.Reference Dabelea, Hanson and Lindsay 26 In addition to diabetes, maternal hyperglycemia, with glucose levels below the diagnostic threshold for gestational diabetes, is associated with increased birth weight 27 and increased newborn adiposity. 28 These increased risks for obesity are likely cumulative, in addition to the home environment, as children tend to eat what their mothers eat.

Pregnancy influences

Excessive GWG is also associated with increased risk of offspring obesity.Reference Olson, Strawderman and Dennison 12 Reference Oken, Rifas-Shiman, Field, Frazier and Gillman 15 The Institute of Medicine (IOM) published guidelines for GWG in 1990 to address the concern that insufficient pregnancy weight gain was contributing to fetal growth restriction. However, in recent years, an estimated 50% of women have exceeded these weight gain guidelines, especially among women who were overweight and obese before pregnancy.Reference Schieve, Cogswell and Scanlon 29 In 2009, the IOM updated its GWG guidelines to address the obesity epidemic; however, it became clear that the evidence base for this determination was lacking comprehensive data.

Conclusion

Understanding the causes for increased childhood obesity rates worldwide is necessary to slow down the obesity epidemic. Genetics alone is not sufficient to explain increased rates of obesity. Obesity risk is likely multifactorial and metabolic programming of pregnancy may be one component of this risk. In summary, evidence exists from human studies that metabolic programming in utero may increase the risk for offspring obesity in specific populations, that is, those exposed to poor nutrition, diabetes or maternal hyperglycemia. However, as most obese children were not exposed to these adverse uterine environments, further research is necessary to understand the mechanisms by which maternal obesity and excessive GWG contribute to increased offspring obesity risk.

References

1. Kim, J, Peterson, KE, Scanlon, KS, et al. . Trends in overweight from 1980 through 2001 among preschool-aged children enrolled in a health maintenance organization. Obesity (Silver Spring). 2006; 14, 11071112.Google Scholar
2. Guo, SS, Wu, W, Chumlea, WC, Roche, AF. Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr. 2002; 76, 653658.CrossRefGoogle ScholarPubMed
3. Oken, E. Maternal and child obesity: the causal link. Obstet Gynecol Clin North Am. 2009; 36, 361377, ix–x.CrossRefGoogle ScholarPubMed
4. Rogers, I. The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord. 2003; 27, 755777.Google Scholar
5. Hirschler, V, Bugna, J, Roque, M, Gilligan, T, Gonzalez, C. Does low birth weight predict obesity/overweight and metabolic syndrome in elementary school children?. Arch Med Res. 2008; 39, 796802.CrossRefGoogle ScholarPubMed
6. Dubois, L, Girard, M. Early determinants of overweight at 4.5 years in a population-based longitudinal study. Int J Obes (Lond). 2006; 30, 610617.CrossRefGoogle Scholar
7. Silverman, BL, Rizzo, TA, Cho, NH, Metzger, BE. Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care. 1998; 21(Suppl 2), B142B149.Google Scholar
8. Pettitt, DJ, Knowler, WC, Bennett, PH, Aleck, KA, Baird, HR. Obesity in offspring of diabetic Pima Indian women despite normal birth weight. Diabetes Care. 1987; 10, 7680.Google Scholar
9. Catalano, PM, Farrell, K, Thomas, A, et al. . Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr. 2009; 90, 13031313.CrossRefGoogle ScholarPubMed
10. Whitaker, RC. Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics. 2004; 114, e29e36.CrossRefGoogle ScholarPubMed
11. Boney, CM, Verma, A, Tucker, R, Vohr, BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005; 115, e290e296.CrossRefGoogle ScholarPubMed
12. Olson, CM, Strawderman, MS, Dennison, BA. Maternal weight gain during pregnancy and child weight at age 3 years. Matern Child Health J. 2009; 13, 839846.Google Scholar
13. Oken, E, Taveras, EM, Kleinman, KP, Rich-Edwards, JW, Gillman, MW. Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol. 2007; 196, 322 e1322 e8.CrossRefGoogle ScholarPubMed
14. Wrotniak, BH, Shults, J, Butts, S, Stettler, N. Gestational weight gain and risk of overweight in the offspring at age 7 y in a multicenter, multiethnic cohort study. Am J Clin Nutr. 2008; 87, 18181824.CrossRefGoogle Scholar
15. Oken, E, Rifas-Shiman, SL, Field, AE, Frazier, AL, Gillman, MW. Maternal gestational weight gain and offspring weight in adolescence. Obstet Gynecol. 2008; 112, 9991006.CrossRefGoogle ScholarPubMed
16. Barker, DJ. The fetal and infant origins of adult disease. BMJ. 1990; 301, 1111.CrossRefGoogle ScholarPubMed
17. Hales, CN, Barker, DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992; 35, 595601.Google Scholar
18. Ravelli, GP, Stein, ZA, Susser, MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976; 295, 349353.CrossRefGoogle ScholarPubMed
19. Yajnik, CS, Deshmukh, US. Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord. 2008; 9, 203211.CrossRefGoogle ScholarPubMed
20. Whitaker, RC, Dietz, WH. Role of the prenatal environment in the development of obesity. J Pediatr. 1998; 132, 768776.CrossRefGoogle ScholarPubMed
21. Pedersen, J. Diabetes and pregnancy. Blood sugar of newborn infants. PhD Thesis. 1952. Danish Science Press: Copenhagen.Google Scholar
22. Freinkel, N. Banting Lecture 1980: of pregnancy and progeny. Diabetes. 1980; 29, 10231035.CrossRefGoogle ScholarPubMed
23. Silverman, BL, Landsberg, L, Metzger, BE. Fetal hyperinsulinism in offspring of diabetic mothers. Association with the subsequent development of childhood obesity. Ann N Y Acad Sci. 1993; 699, 3645.CrossRefGoogle ScholarPubMed
24. Lake, JK, Power, C, Cole, TJ. Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Arch Dis Child. 1997; 77, 376381.Google Scholar
25. Kral, JG, Biron, S, Simard, S, et al. . Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics. 2006; 118, e1644e1649.CrossRefGoogle ScholarPubMed
26. Dabelea, D, Hanson, RL, Lindsay, RS, et al. . Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000; 49, 22082211.CrossRefGoogle ScholarPubMed
27. The HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008; 358, 19912002.Google Scholar
28. The HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes. 2009; 58, 453459.CrossRefGoogle Scholar
29. Schieve, LA, Cogswell, ME, Scanlon, KS. Trends in pregnancy weight gain within and outside ranges recommended by the Institute of Medicine in a WIC population. Matern Child Health J. 1998; 2, 111116.CrossRefGoogle Scholar