Brain Impairment

Articles

Behavioural and Psychiatric Symptoms in Patients With Neurodegenerative Diseases

Claire Lomaxa1, Richard G. Browna2 c1, K. Ray Chaudhuria3 and Robert J. Howarda4

a1 MRC Centre for Neurodegeneration Research, King' College London, Institute of Psychiatry, Department of Psychology.

a2 MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Psychology.

a3 Department of Neurology, King's College Hospital.

a4 MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Division of Psychological Medicine, Section of Old Age Psychiatry.

Abstract

Neuropsychiatric symptoms are common features in patients with neurodegenerative diseases, and have important clinical implications for both patients and caregivers. This study used the Neuropsychiatric Inventory (NPI) to measure symptomatology in 120 patients drawn from five disease groups: Parkinson's disease (PD), Alzheimer's disease (AD), dementia associated with Lewy bodies (DLB), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Ninety per cent of the patient group reported experiencing at least one symptom, with the most prevalent symptoms being depression and apathy. However, a differential pattern of symptomatology was reported across the disease groups, a finding which has diagnostic and treatment implications. Furthermore, this provides additional evidence that a broad cortical–subcortical distinction cannot be supported.

Correspondence:

c1 Address for correspondence: Dr Richard Brown, Department of Psychology, Institute of Psychiatry, PO77, De Crespigny Park, London SE5 8AF, UK. E-mail: r.brown@iop.kcl.ac.uk