Twin Research

Table of Contents - 01 April 2004 - Volume 7, Issue 02  

Articles

Using Identity-by-descent Information in Affected Sib Pairs to Increase the Efficiency of Genetic Association Studies

Jacqueline Wicksa1 c1, Susan A. Treloara2 and Nicholas G. Martina3

a1 Queensland Institute of Medical Research, Brisbane,Australia. jackiW@qimr.edu.au

a2 Queensland Institute of Medical Research, Brisbane,Australia.

a3 Queensland Institute of Medical Research, Brisbane,Australia.

Abstract

The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families.

(Received July 31 2003)

(Accepted January 05 2004)

Correspondence:

c1 Address for correspondence: Jacqueline Wicks, Queensland Institute of Medical Research, Brisbane Qld 4029, Australia.

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