Twin Research

Articles/Netherlands

Netherlands Twin Register: A Focus on Longitudinal Research

Dorret I. Boomsmaa1 c1, Jacqueline M. Vinka2, Toos C. E .M. van Beijsterveldta3, Eco J. C. de Geusa4, A. Leo Beema5, Elles J. C. M. Muldera6, Eske M. Derksa7, Harriette Riesea8, Gonneke A. H. M. Willemsena9, Meike Bartelsa10, Mireille van den Berga11, Nina H. M. Kuppera12, Tinca J. C. Poldermana13, Danielle Posthumaa14, Marjolein J. H. Rietvelda15, Janine H. Stubbea16, Louise I. Knola17, Therese Stroeta18 and G. Caroline M. van Baala19

a1 Department of Biological Psychology,Vrije Universiteitdorret@psy.vu.nl

a2 Department of Biological Psychology,Vrije Universiteit

a3 Department of Biological Psychology,Vrije Universiteit

a4 Department of Biological Psychology,Vrije Universiteit

a5 Department of Biological Psychology,Vrije Universiteit

a6 Department of Biological Psychology,Vrije Universiteit

a7 Department of Biological Psychology,Vrije Universiteit

a8 Department of Biological Psychology,Vrije Universiteit

a9 Department of Biological Psychology,Vrije Universiteit

a10 Department of Biological Psychology,Vrije Universiteit

a11 Department of Biological Psychology,Vrije Universiteit

a12 Department of Biological Psychology,Vrije Universiteit

a13 Department of Biological Psychology,Vrije Universiteit

a14 Department of Biological Psychology,Vrije Universiteit

a15 Department of Biological Psychology,Vrije Universiteit

a16 Department of Biological Psychology,Vrije Universiteit

a17 Department of Biological Psychology,Vrije Universiteit

a18 Department of Biological Psychology,Vrije Universiteit

a19 Department of Biological Psychology,Vrije Universiteit

Abstract

In 1986 we began The Netherlands Twin Register (NTR) by recruiting young twins and multiples a few weeks or months after birth. Currently we register around 50% of all newborn multiples in The Netherlands. Their parents receive a questionnaire at registration and afterwards when the children are 2, 3, 5, 7, 10 and 12 years of age. Teachers are asked to rate the behavior of the children at ages 7, 10 and 12 years. Adolescent and young-adult twins were recruited through City Councils in the early 1990s. These twins, their parents and siblings participate in longitudinal survey studies that include items about health, fertility, lifestyle, addiction, personality and psychopathology, religion, socioeconomic status, and educational attainment. The total number of twins and multiples registered with the NTR is currently over 60,000. Subgroups of twins and siblings take part in studies of cognitive development, brain function and neuropsychological indices of attention processes, and molecular genetic studies of classical and behavioral cardiovascular risk factors. DNA samples are currently collected in selected twin families for two large linkage studies, which aim to find QTLs for anxious depression and for nicotine addiction. Sisters who are mothers of DZ twins contribute DNA samples for a linkage study of DZ twinning. Large cohorts of phenotyped family members from the general population are very valuable for genetic epidemiological studies and permit selection of informative families for gene finding studies.

Correspondence:

c1 Address for correspondence: Dorret I. Boomsma, Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

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