Twin Research

Articles

Fetal Growth and the Fetal Origins Hypothesis in Twins — Problems and Perspectives

David I.W. Phillipsa1 c1, Michael J. Daviesa2 and Jeffrey S. Robinsona3

a1 MRC Unit(University of Southampton), Southampton General Hospital, UK. diwp@mrc.soton.ac.uk

a2 Department of Obstetrics and Gynaecology, University of Adelaide, Australia.

a3 Department of Obstetrics and Gynaecology, University of Adelaide, Australia.

Abstract

Although there is substantial evidence from studies of singletons that small size at birth is linked with long-term adverse health effects, until recently little was known as to whether these associations extend to twins. A review of published studies suggests that at present there is little consistent evidence that birthsize in twins is associated with increased morbidity or morality. While, these findings may reflect methodological limitations, it is also argued that they arise as a consequence of the substantially different biology of fetal growth in twins.

Correspondence:

c1 Address for correspondence: Prof. DIW Phillips PhD FRCP, MRC Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, The United Kingdom.

Metrics