Neuron Glia Biology

Research Article

The role of enteric glia in gut inflammation

Georg von Boyena1 c1 and Martin Steinkampa2

a1 Department of Internal Medicine I (Gastroenterology), University of Ulm, Ulm, Germany

a2 Department of Gastroenterology, Endocrinology and Metabolism, University of Marburg, Marburg, Germany

Abstract

A neuro-glia interaction is part of gut inflammation and essential for the integrity of the bowel. A loss of enteric glia cells (EGCs) led to a fatal haemorrhagic jejuno-ileitis and death in a few days. Although a diminished EGC network is postulated in inflammatory bowel disease and enteric glia pathology is described in Chagas' disease the role of EGCs in the onset of these disease complexes is not definitely clear. Several lines of evidence implicate that the secretion of different factors by enteric glia may be the key for modulating gut homeostasis. As mucosal integrity might be important for remission in Crohn's disease and inflammation of the enteric nervous system is part of the pathology in Chagas' disease, the role of EGCs during gut inflammation could be part of the key to understand these diseases.

Correspondence:

c1 Correspondence should be addressed to: Georg von Boyen, Klinik für Innere Medizin I, Universitätsklinikum Ulm, Albert-Einstein Allee 23, 89081 Ulm, Germany phone: +49 731 500 44603 fax: +49 731 500 44610 email: georg.boyen@uniklinik-ulm.de