British Journal of Nutrition

Human and Clinical Nutrition

Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case–control study of children

Adriana Moleresa1, M. Carmen Ochoaa2, Tara Rendo-Urteagaa1, M. Angel Martínez-Gonzáleza3, M. Cristina Azcona San Juliána4, J. Alfredo Martíneza1 and Amelia Martia1 c1

on behalf of GENOI

a1 Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, C/Irunlarrea s/n, Pamplona 31008, Spain

a2 Center for Applied Medical Research, University of Navarra, Pamplona, Spain

a3 Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

a4 Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain

Abstract

The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts. This association appears to be dependent on dietary macronutrients. Therefore, the aim of the present study was to evaluate whether dietary fatty acid intake distribution could interact with this FTO genetic variation and obesity in a Spanish case–control study of children and adolescents. A total of 354 Spanish children and adolescents aged 6–18 years (49 % males) were genotyped for the rs9939609 variant of the FTO gene. Anthropometric parameters were taken and energy intake was measured. We observed an interaction between the consumption of SFA (percentage of total energy) and PUFA:SFA ratio and obesity risk linked to the rs9939609 SNP of the FTO gene. In the study population of the present study, the risk allele carriers consuming more than 12·6 % SFA (of total energy) had an increased obesity risk compared with TT carriers. In a similar way, A allele carriers with an intake ratio lower than 0·43 PUFA:SFA presented a higher obesity risk than TT subjects. In summary, the present study reports for the first time the influence of dietary fatty acid distribution on the effect of the rs9939609 polymorphism of the FTO gene on children and adolescents' obesity risk.

(Received December 01 2010)

(Revised April 21 2011)

(Accepted May 23 2011)

(Online publication July 29 2011)

Correspondence:

c1 Corresponding author: Dr A. Marti, fax +34 948425740, email amarti@unav.es

Footnotes

† Other members of GENOI are: M. Chueca, M. Oyarzabal, A. Patiño, R. Pelach and M. J. Moreno-Aliaga.

Abbreviations: FTO, fat mass and obesity associated; SDS, standard deviation score

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