Psychological Medicine

Original Articles

The effects of puberty on genetic risk for disordered eating: evidence for a sex difference

K. L. Klumpa1 c1, K. M. Culberta1, J. D. Slanea1, S. A. Burta1, C. L. Siska2 and J. T. Nigga3

a1 Department of Psychology, Michigan State University, East Lansing, MI, USA

a2 Psychology and Neuroscience, Michigan State University, East Lansing, MI, USA

a3 Department of Psychiatry, Oregon Health and Science University, Portland, OR, USA

Abstract

Background Differences in genetic influences on disordered eating are present across puberty in girls. Heritability is 0% before puberty, but over 50% during and after puberty. Emerging data suggest that these developmental differences may be due to pubertal increases in ovarian hormones. However, a critical piece of evidence is lacking, namely, knowledge of genetic influences on disordered eating across puberty in boys. Boys do not experience increases in ovarian hormones during puberty. Thus, if pubertal increases in genetic effects are present in boys, then factors in addition to ovarian hormones may drive increases in heritability in girls. The current study was the first to examine this possibility in a sample of 1006 male and female twins from the Michigan State University Twin Registry.

Method Disordered eating was assessed with the Minnesota Eating Behavior Survey. Pubertal development was assessed with the Pubertal Development Scale.

Results No significant differences in genetic influences on disordered eating were observed in males across any developmental stage. Heritability was 51% in boys during pre-puberty, puberty and young adulthood. By contrast, in girls, genetic factors accounted for 0% of the variance in pre-puberty, but 51% of the variance during puberty and beyond. Sex differences in genetic effects were only significant during pre-puberty, as the best-fitting models constrained heritability to be equal across all males, pubertal females and young adult females.

Conclusions The results highlight sex-specific effects of puberty on genetic risk for disordered eating and provide indirect evidence of a role for ovarian hormones and/or other female-specific factors.

(Received April 01 2011)

(Revised June 28 2011)

(Accepted July 05 2011)

(Online publication August 22 2011)

Correspondence

c1 Address for correspondence: K. L. Klump, Ph.D., Department of Psychology, Michigan State University, 107B Psychology Building, East Lansing, MI 48824-1116, USA. (Email: klump@msu.edu)

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