British Journal of Nutrition

Meta-analysis

Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis

Guogang Lia1, Lan Lia2, Chaohui Yua2 and Li Chena1 c1

a1 Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88, Jiefang Road, Hangzhou 310009, People's Republic of China

a2 Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China

Abstract

Vitamins C and E can act as potent antioxidants to reduce the damage caused by reactive oxygen species in gastric mucosa. Whether vitamin supplements for Helicobacter pylori eradication regimen could improve the rate of eradication remains uncertain. Therefore, we performed a meta-analysis to evaluate the efficacy of vitamins C and E supplementation for the eradication of H. pylori. Searches were conducted in the databases PubMed, EMBASE and Cochrane Library. Randomised controlled trials (RCT) that fulfilled the inclusion criteria and addressed the clinical questions of this analysis were further assessed. Of the six RCT included, five had a low methodological quality. Of the six RCT, three compared the efficacy of the eradication regimen v. eradication regimen plus vitamins C and E. The result of the meta-analysis showed a non-significant difference in the eradication rate of H. pylori between the two groups (risk ratio (RR) 0·93, P = 0·76). Another three RCT compared the eradication regimen v. eradication regimen plus vitamin C only, and there too there was no significant difference in the eradication rate (RR 0·83, P = 0·32). In conclusion, vitamins C and/or E supplements to the H. pylori eradication regimen could not improve the eradication rate. However, currently available data do not draw a definitive conclusion about the effectiveness of antioxidant vitamins on H. pylori eradication, owing to the small sample size and low-to-moderate methodological quality.

(Received November 30 2010)

(Revised June 15 2011)

(Accepted June 15 2011)

(Online publication August 03 2011)

Correspondence:

c1 Corresponding author: Professor L. Chen, fax +86 571 87022776, email chenli_zju@163.com

Footnotes

Abbreviations: PPI, proton pump inhibitor; RCT, randomised controlled trial

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