Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-24T02:02:57.100Z Has data issue: false hasContentIssue false
  • English
  • Français

Factors influencing the composition of the weight lost by obese patients on a reducing diet

Published online by Cambridge University Press:  09 March 2007

Merril L. Durrant ,
J. S. Garrow ,
P. Royston ,
Susan F. Stalley ,
Shirley Sunkin  and
Penelope M. Warwick
Merril L. Durrant
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
J. S. Garrow
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
P. Royston
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Susan F. Stalley
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Shirley Sunkin
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Penelope M. Warwick
Affiliation:
MRC Clinical Research Centre, Watford Road, Harrow, Middlesex
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1.Weight loss, resting metabolic rate and nitrogen loss were measured in forty obese inpatients on reducing diets.

2. Five subjects ate 3·55 MJ/d for 6 weeks (Expt I). Twenty-one subjects ate 4.2 MJ/d for the first week, 2·0 MJ/d for the second week and 4 2 MJ/d for the third week (Expt 2). Fourteen subjects ate 3·4 MJ/d for the first week and then 0.87 MJ protein or carbohydrate for the second or third weeks, using a cross-over design for alternate patients (Expt 3).

3. Patients in Expt I had highest weight loss and N loss in the first 2 weeks, but adapted to the energy restriction over the remaining weeks. On average subjects were in N balance at the end of the study.

4. In Expt 2 patients eating 2·0 MJ/d in week 2 showed increased weight loss compared with week I.N loss was not raised but it failed to decrease as it had in Expt I. Weight loss and N loss were reduced on return to 4.2 MJ/d for a third week.

5. In Expt 3 patients eating 0·87 MJ protein showed significantly more weight loss and less N loss than patients eating 0·87 MJ carbohydrate.

6. Resting metabolic rate decreased with time on the low-energy diet, but the manipulations of energy or protein content did not significantly affect the pattern of decrease.

7. Both weight loss and N loss were greater the lower the energy intake, and both decreased with time. Diets with a high protein:energy value give a favourable value for N:weight loss at each level of energy intake.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 3 , November 1980 , pp. 275 - 285
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Apfelbaum, M., Bost-Sarron, J., Brigant, L.Dupin, H. (1967), Gastroenterologia 108, 121.CrossRefGoogle Scholar
Baird, I. McL., Parsons, R. L.Howard, A. N. (1974). Metabolism 23, 645.CrossRefGoogle Scholar
Bistrian, B.R., Winterer, J., Blackburn, G. L., Young, V. & Sherman, M. (1977). J. Lab. clin. Med. 89, 1030.Google Scholar
Blackburn, G. L., Flatt, J. P., Clowes, G. H. A., O'Donnel, T. F. & Hensle, T. E. (1973). Annls Surg. 177, 588.CrossRefGoogle Scholar
Boddy, K., Hume, R., White, C., Pack, A., King, P. C., Weyers, E., Rowan, T. & Mills, E. (1976), Clin. Sci. mol. Med. 50, 455.Google Scholar
Calloway, D. H. & Spector, H. (1954), Am. J. clin. Nutr. 2, 405.CrossRefGoogle Scholar
Forbes, G. B. & Drenick, E. J. (1979), Am. J. clin. Nutr. 32, 1570.Google Scholar
Garrow, J. S., Durrant, M. L., Mann, S., Stalley, S. F. & Warwick, P. (1978), Int. J. Obesity 2, 441.Google Scholar
Garrow, J. S. & Hawes, S. F. (1972), Br. J. Nutr. 27, 211.CrossRefGoogle Scholar
Garrow, J. S., Stalley, S., Diethelm, R., Pittet, P., Hesp, R. & Halliday, D. (1979), Br. J. Nutr. 42, 173.CrossRefGoogle Scholar
Genuth, S. M., Castro, J. H. & Vertes, V. (1974), J. Am. med. Ass. 230, 987.Google Scholar
Halliday, D., Hesp, R., Stalley, S. F., Warwick, P., Altman, D. G. & Garrow, J. S. (1979), Int. J. Obesity 3, 1.Google Scholar
Howard, A. N. & Baird, I. McL. (1977), Int. J. Obesity 1, 63.Google Scholar
Keys, A., Brozek, J., Henschel, A., Mickelson, O., & Taylor, H. L. (1950). The Biology of Human Starvation, Minneapolis: University of Minnesota Press.Google Scholar
Smith, T., Hesp, R. & MacKenzie, J. (1979), Phys. Med. Biol. 24, 171.CrossRefGoogle Scholar
van Itallie, T. B. & Yang, M-U. (1977). In Recent Advances in Obesity Research vol. 2, p. 379 [Bray, G., editor]. London: Newman Publishing.Google Scholar
Wilson, J. H. P. & Lamberts, S. W. J. (1979), Am. J. clin. Nutr. 31, 1612.CrossRefGoogle Scholar