Epidemiology and Infection



The relationships between the HIV test interval, demographic factors and HIV disease progression


CASCADE European Collaborative Project and c1

Abstract

Individuals developing an HIV seroconversion illness may experience rapid disease progression. Information on seroconversion illness is rarely collected in most cohort studies; thus the aim of this study was to assess the value of the HIV test interval (the time between last negative and first positive HIV tests) as a proxy for seroconversion illness. Among 8229 seroconverters, test intervals ranged from 0–5282 days, and varied by gender, risk group, age and calendar year of seroconversion. Those with intervals [less-than-or-eq, slant] 31 days had an increased hazard of AIDS (RH 1·42, P = 0·07), which was reduced slightly after adjusting for baseline factors, calendar year of follow-up, treatment and the declining CD4 count, but there was no effect on survival. Thus, it appears that if information on acute seroconversion illness is not available, then analyses of progression to AIDS in seroconverter studies could use a short test interval as a proxy measure.

(Accepted March 27 2001)


Correspondence:
c1 Author for correspondence: Dr C. A. Sabin, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF. Requests for reprints: Dr K. Porter, MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA.


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