Journal of the International Neuropsychological Society

Regular Articles

Relation of Parkinson's Disease Subtypes to Visual Activities of Daily Living

Daniel R. Seichepinea1, Sandy Neargardera1a2, Ivy N. Millera1, Tatiana M. Riedela3, Grover C. Gilmorea3 and Alice Cronin-Golomba1 c1

a1 Department of Psychology, Boston University, Boston, Massachusetts

a2 Department of Psychology, Bridgewater State University, Bridgewater, Massachusetts

a3 Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, Ohio

Abstract

Visual perceptual problems are common in Parkinson's disease (PD) and often affect activities of daily living (ADLs). PD patients with non-tremor symptoms at disease onset (i.e., rigidity, bradykinesia, gait disturbance or postural instability) have more diffuse neurobiological abnormalities and report worse non-motor symptoms and functional changes than patients whose initial symptom is tremor, but the relation of motor symptom subtype to perceptual deficits remains unstudied. We assessed visual ADLs with the Visual Activities Questionnaire in 25 non-demented patients with PD, 13 with tremor as the initial symptom and 12 with an initial symptom other than tremor, as well as in 23 healthy control participants (NC). As expected, the non-tremor patients, but not the tremor patients, reported more impairment in visual ADLs than the NC group, including in light/dark adaptation, acuity/spatial vision, depth perception, peripheral vision and visual processing speed. Non-tremor patients were significantly worse than tremor patients overall and on light/dark adaptation and depth perception. Environmental enhancements especially targeted to patients with the non-tremor PD subtype may help to ameliorate their functional disability. (JINS, 2011, 17, 841–852)

(Received August 19 2010)

(Revised May 25 2011)

(Accepted May 25 2011)

(Online publication August 04 2011)

Correspondence:

c1 Correspondence and reprint requests to: Alice Cronin-Golomb, Department of Psychology, Boston University, 648 Beacon Street, 2nd floor, Boston, MA 02215. E-mail: alicecg@bu.edu

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