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Memory Transformation and Systems Consolidation

Published online by Cambridge University Press:  06 June 2011

Gordon Winocur  and
Morris Moscovitch
Gordon Winocur*
Affiliation:
Rotman Research Institute, Baycrest Centre, Toronto, Canada Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada Department of Psychology, Trent University, Peterborough, Canada
Morris Moscovitch
Affiliation:
Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, Baycrest Centre, Toronto, Canada Department of Psychology, University of Toronto, Toronto, Canada
*
Correspondence and reprint requests to: Gordon Winocur, Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A Canada. E-mail: gwinocur@rotman-baycrest.on.ca
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Abstract

With time and experience, memories undergo a process of reorganization that involves different neuronal networks, known as systems consolidation. The traditional view, as articulated in standard consolidation theory (SCT), is that (episodic and semantic) memories initially depend on the hippocampus, but eventually become consolidated in their original forms in other brain regions. In this study, we review the main principles of SCT and report evidence from the neuropsychological literature that would not be predicted by this theory. By comparison, the evidence supports an alternative account, the transformation hypothesis, whose central premise is that changes in neural representation in systems consolidation are accompanied by corresponding changes in the nature of the memory. According to this view, hippocampally dependent, episodic, or context-specific memories transform into semantic or gist-like versions that are represented in extra-hippocampal structures. To the extent that episodic memories are retained, they will continue to require the hippocampus, but the hippocampus is not needed for the retrieval of semantic memories. The transformation hypothesis emphasizes the dynamic nature of memory, as well as the underlying functional and neural interactions that must be taken into account in a comprehensive theory of memory. (JINS, 2011, 17, 766–780)

Keywords

MemoryHippocampusSystemsConsolidationTransformationRetrograde amnesia
Type
Critical Review
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 5 , September 2011 , pp. 766 - 780
Copyright
Copyright © The International Neuropsychological Society 2011

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References

REFERENCES

Addis, D.R., Moscovitch, M., Crawley, A.P., McAndrews, M.P. (2004). Recollective qualities modulate hippocampal activation during autobiographical memory retrieval. Hippocampus, 14, 752–762.CrossRefGoogle ScholarPubMed
Addis, D.R., Schacter, D.L. (2008). Constructive episodic simulation: Temporal distance and detail of past and future events modulate hippocampal engagement. Hippocampus, 18, 227–237.CrossRefGoogle ScholarPubMed
Ahles, T.A., Saykin, A.J. (2007). Candidate mechanisms for chemotherapy-induced cognitive changes. Nature Reviews Cancer, 7, 192–201.CrossRefGoogle ScholarPubMed
Albert, M., Butters, N., Levin, J. (1979). Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease. Archives of Neurology, 36, 211–216.CrossRefGoogle ScholarPubMed
Barr, W.B., Goldberg, E., Wasserstein, J., Novelly, R.A. (1990). Retrograde amnesia following unilateral temporal lobectomy. Neuropsychologia, 28, 243–255.CrossRefGoogle ScholarPubMed
Barrash, J. (1998). A historical review of topographical disorientation and its neuroanatomical correlates. Journal of Clinical Experimental Neuropsychology, 20, 807–827.CrossRefGoogle ScholarPubMed
Bayley, P.J., Frascino, J.C., Squire, L.R. (2005). Robust habit learning in the absence of awareness and independent of the medial temporal lobe. Nature, 436, 550–553.CrossRefGoogle ScholarPubMed
Bayley, P.J., Hopkins, R.O., Squire, L.R. (2003). Successful recollection of remote autobiographical memories by amnesic patients with medial temporal lobe lesions. Neuron, 38, 135–144.CrossRefGoogle ScholarPubMed
Bayley, P.J., Hopkins, R.O., Squire, L.R. (2006). The fate of old memories after medial temporal lobe damage. Journal of Neuroscience, 26, 13311–13317.CrossRefGoogle ScholarPubMed
Bird, C.M., Burgess, N. (2008). The hippocampus and memory: Insights from spatial processing. Nature Reviews Neuroscience, 9, 182–194.CrossRefGoogle ScholarPubMed
Bright, P., Buckman, J., Fradera, A., Yoshimasu, H., Colchester, A.C., Kopelman, M.D. (2006). Retrograde amnesia in patients with hippocampal, medial temporal, temporal lobe, or frontal pathology. Learning and Memory, 13, 545–557.CrossRefGoogle ScholarPubMed
Brunet, A., Orr, S.P., Tremblay, J., Robertson, K., Nader, K., Pitman, R.K. (2008). Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. Journal of Psychiatric Research, 42, 503–506.CrossRefGoogle ScholarPubMed
Burnham, W.H. (1904). Retroactive amnesia: Illustrative cases and a tentative explanation. American Journal of Psychology, 14, 382–396.Google Scholar
Cermak, L.S. (1984). The episodic-semantic distinction in memory. In L.R. Squire & N. Butters (Eds.), The neuropsychology of memory (pp. 55–62). New York: Guilford Press.Google Scholar
Cermak, L.S., O'Connor, M. (1983). The anterograde and retrograde retrieval ability of a patient with amnesia due to encephalitis. Neuropsychologia, 21, 213–234.CrossRefGoogle ScholarPubMed
Chan, D., Henley, S.M., Rossor, M.N., Warrington, E.K. (2007). Extensive and temporally ungraded retrograde amnesia in encephalitis associated with antibodies to voltage-gated potassium channels. Archives of Neurology, 64, 404–410.CrossRefGoogle ScholarPubMed
Chan, J.C., Thomas, A.K., Bulevich, J.B. (2009). Recalling a witnessed event increases eyewitness suggestibility: The reversed testing effect. Psychological Science, 20, 66–73.CrossRefGoogle ScholarPubMed
Cipolotti, L., Shallice, T., Chan, D., Fox, N., Scahill, R., Harrison, G., Rudge, P. (2001). Long-term retrograde amnesia…the crucial role of the hippocampus. Neuropsychologia, 39, 151–172.CrossRefGoogle Scholar
Conway, M.A., Pleydell-Pearce, C.W. (2000). The construction of autobiographical memories in the self-memory system. Psychological Review, 107, 261–288.CrossRefGoogle ScholarPubMed
Corkin, S. (1984). Lasting consequences of bilateral medial temporal lobectomy: Clinical course and experimental findings in H.M. Neurology, 4, 249–259.Google Scholar
Crovitz, H.F., Schiffman, H. (1974). Frequency of episodic memories as a function of age. Bulletin of the Psychonomic Society, 4, 517–518.CrossRefGoogle Scholar
Damasio, A.R., Eslinger, P.J., Damasio, H., Van Hoesen, G.W., Cornell, S. (1985). Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage. Archives of Neurology, 42, 252–259.CrossRefGoogle ScholarPubMed
Daselaar, S.M., Rice, H.J., Greenberg, D.L., Cabeza, R., LaBar, K.S., Rubin, D.C. (2008). The spatiotemporal dynamics of autobiographical memory: Neural correlates of recall, emotional intensity, and reliving. Cerebal Cortex, 18, 217–229.CrossRefGoogle ScholarPubMed
D'Esposito, M., Verfaille, M., Alexander, M.P., Katz, D. (1995). Amnesia following traumatic bilateral fornix transaction. Neurology, 45, 1546–1550.CrossRefGoogle Scholar
Eichenbaum, H., Otto, T., Cohen, N.J. (1994). Two functional components of the hippocampal memory system. Behavioral and Brain Sciences, 17, 449–518.CrossRefGoogle Scholar
Eichenbaum, H., Yonelinas, A.P., Ranganath, C. (2007). The medial temporal lobe and recognition memory. Annual Review of Neuroscience, 30, 123–152.CrossRefGoogle ScholarPubMed
Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Maldonado, H. (2007). Reconsolidation of declarative memory in humans. Learning and Memory, 14, 295–303.CrossRefGoogle ScholarPubMed
Frankland, P.W., Bontempi, B. (2005). The organization of recent and remote memories. Nature Reviews Neuroscience, 6, 119–130.CrossRefGoogle ScholarPubMed
Fujii, T., Moscovitch, M., Nadel, L. (2000). Consolidation, retrograde amnesia, and the temporal lobe. In F. Boller, & J. Grafman (Eds.), The handbook of neuropsychology (2nd ed., Vol. 2). Amsterdam: Elsevier.Google Scholar
Gaffan, D., Wilson, C.R. (2008). Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey. Cortex, 44, 928–935.CrossRefGoogle ScholarPubMed
Gilboa, A., Winocur, G., Grady, C.L., Hevenor, S.J., Moscovitch, M. (2004). Remembering our past: Functional neuroanatomy of recollection of recent and very remote personal events. Cerebral Cortex, 14, 1214–1225.CrossRefGoogle ScholarPubMed
Gilboa, A., Winocur, G., Rosenbaum, R.S., Poreh, A., Gao, F., Black, S.E., Moscovitch, M. (2006). Hippocampal contributions to recollection in retrograde and anterograde amnesia. Hippocampus, 16, 966–980.CrossRefGoogle ScholarPubMed
Graham, K.S., Patterson, K., Hodges, J.R. (1999). Episodic memory: New insights from the study of semantic dementia. Current Opinion in Neurobiology, 9, 245–250.CrossRefGoogle Scholar
Graham, K.S., Simons, J.S., Pratt, K.H., Patterson, K., Hodges, J.R. (2000). Insights from semantic dementia on the relationship between episodic and semantic memory. Neuropsychologia, 38, 313–324.CrossRefGoogle ScholarPubMed
Greene, J.D., Hodges, J.R., Baddeley, A.D. (1995). Autobiographical memory and executive function in early dementia of Alzheimer type. Neuropsychologia, 33, 1647–1670.CrossRefGoogle ScholarPubMed
Hassabis, D., Kumaran, D., Vann, S.D., Maguire, E.A. (2007). Patients with hippocampal amnesia cannot imagine new experiences. Proceedings of the National Academy of Sciences of United States of America, 104, 1726–1731.CrossRefGoogle ScholarPubMed
Hepner, I.J., Mohamed, A., Fulham, M.J., Miller, L.A. (2007). Topographical, autobiographical and semantic memory in a patient with bilateral mesial temporal and retrosplenial infarction. Neurocase, 13, 97–114.CrossRefGoogle Scholar
Hirano, M., Noguchi, K. (1998). Dissociation between specific personal episodes and other aspects of remote memory in a patient with hippocampal amnesia. Perceptual and Motor Skills, 87, 99–107.CrossRefGoogle Scholar
Hirshhorn, M., Newman, L., Moscovitch, M. (2010). Detailed descriptions of routes travelled, but not map-like knowledge correlate with tests of hippocampal function. Hippocampus [Epub ahead of print].Google Scholar
Hodges, J.R., Carpenter, K. (1991). Anterograde amnesia with fornix damage following removal of IIIrd ventricle colloid cyst. Journal of Neurology, Neurosurgery, and Psychiatry, 54, 633–638.CrossRefGoogle ScholarPubMed
Hou, C.E., Miller, B.L., Kramer, J.H. (2005). Patterns of autobiographical memory loss in dementia. International Journal of Geriatric Psychiatry, 20, 809–815.CrossRefGoogle ScholarPubMed
Hupbach, A., Gomez, R., Hardt, O., Nadel, L. (2007). Reconsolidation of episodic memories: A subtle reminder triggers integration of new information. Learning and Memory, 14, 47–53.CrossRefGoogle ScholarPubMed
Hupbach, A., Hardt, O., Gomez, R., Nadel, L. (2008). The dynamics of memory: Context-dependent updating. Learning and Memory, 15, 574–579.CrossRefGoogle ScholarPubMed
Ivanoiu, A., Cooper, J.C., Shanks, M.F., Venneri, A. (2004). Retrieval of episodic and semantic autobiographical memories in early Alzheimer's Disease and Semantic Dementia [abstract]. Cortex, 40, 173–175.CrossRefGoogle ScholarPubMed
Kapur, N., Brooks, D.J. (1999). Temporally-specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology. Hippocampus, 9, 247–254.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Kartsounis, L.R., Rudge, P., Stevens, J.M. (1995). Bilateral lesion of CA1-CA2 fields of the hippocampus are sufficient to cause a severe amnesic syndrome in humans. Journal of Neurology, Neurosurgery, and Psychiatry, 59, 95–98.CrossRefGoogle Scholar
Kinsbourne, M., Wood, F. (1975). Short-term memory processes and the amnesic syndrome. In D. Deutsch, & A.J. Deutsch (Eds.), Short-term memory (pp. 258–291). New York: Academic Press.Google Scholar
Kirwan, C.B., Bayley, P.J., Galvan, V.V., Squire, L.R. (2008). Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe. Proceedings of the National Academy of Sciences of United States of America, 105, 2676–2680.CrossRefGoogle Scholar
Kopelman, M.D. (1989). Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients. Neuropsychologia, 27, 437–460.CrossRefGoogle ScholarPubMed
Kopelman, M.D., Stanhope, N., Kingsley, D. (1999). Retrograde amnesia in patients with diencephalic, temporal lobe or frontal lesions. Neuropsychologia, 37, 939–958.CrossRefGoogle ScholarPubMed
Kopelman, M.D., Wilson, B.A., Baddeley, A.D. (1989). The autobiographical memory interview: A new assessment of autobiographical and personal semantic memory in amnesic patients. Journal of Clinical and Experimental Neuropsychology, 11, 724–744.CrossRefGoogle ScholarPubMed
Levine, B., Svoboda, E., Hay, J.F., Winocur, G., Moscovitch, M. (2002). Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychology and Aging, 17, 677–689.CrossRefGoogle ScholarPubMed
Leyhe, T., Muller, S., Eschweiler, G.W., Saur, R. (2010). Deterioration of the memory for historic events in patients with mild cognitive impairment and early Alzheimer's disease. Neuropsychologia, 48, 4093–4101.CrossRefGoogle ScholarPubMed
Leyhe, T., Muller, S., Milian, M., Eschweiler, G.W., Saur, R. (2009). Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease. Neuropsychologia, 47, 2464–2469.CrossRefGoogle ScholarPubMed
Loftus, E. (2003). Our changeable memories: Legal and practical implications. Nature Reviews Neuroscience, 4, 231–234.CrossRefGoogle ScholarPubMed
Maguire, E.A., Kumaran, D., Hassabis, D., Kopelman, M.D. (2010). Autobiographical memory in semantic dementia: A longitudinal fMRI study. Neuropsychologia, 48, 123–136.CrossRefGoogle ScholarPubMed
Maguire, E.A., Nannery, R., Spiers, H.J. (2006). Navigation around London by a taxi driver with bilateral hippocampal lesions. Brain, 129, 2894–2907.CrossRefGoogle ScholarPubMed
Manns, J.R., Hopkins, R.O., Squire, L.R. (2003). Semantic memory and the human hippocampus. Neuron, 38, 127–133.CrossRefGoogle ScholarPubMed
Marslen-Wilson, W., Teuber, H.L. (1975). Memory for remote events in anterograde amnesia: Recognition of public figures from news photographs. Neuropsychologia, 13, 353–364.CrossRefGoogle Scholar
Maviel, T., Durkin, T.P., Menzaghi, F., Bontempi, B. (2004). Sites of neocortical reorganization critical for remote spatial memory. Science, 305, 96–99.CrossRefGoogle ScholarPubMed
Mayes, A.R., Montaldi, D. (1997). Neuroradiological approaches to the study of organic amnesia. In A.J. Parkin (Ed.), Studies in the neuropsychology of memory (pp. 7–33). East Sussex: Psychology Press.Google Scholar
McKinnon, M.C., Black, S.E., Miller, B., Moscovitch, M., Levine, B. (2006). Autobiographical memory in semantic dementia: Implication for theories of limbic-neocortical interaction in remote memory. Neuropsychologia, 44, 2421–2429.CrossRefGoogle ScholarPubMed
Moscovitch, M. (1992). Memory and working-with-memory: A component process model based on modules and central systems. Journal of Cognitive Neuroscience, 4, 257–267.CrossRefGoogle ScholarPubMed
Moscovitch, M., Nadel, L., Winocur, G., Gilboa, A., Rosenbaum, R.S. (2006). The cognitive neuroscience of remote episodic, semantic and spatial memory. Current Opinion in Neurobiology, 16, 179–190.CrossRefGoogle ScholarPubMed
Moscovitch, M., Rosenbaum, R.S., Gilboa, A., Addis, D.R., Westmacott, R., Grady, C., Nadel, L. (2005). Functional neuroanatomy of remote episodic, semantic and spatial memory: A unified account based on multiple trace theory. Journal of Anatomy, 207, 35–66.CrossRefGoogle ScholarPubMed
Moscovitch, M., Winocur, G. (2002). The frontal cortex and working with memory. In D.T. Stuss, & R.T. Knight (Eds.), Principles of frontal lobe function (pp. 188–209). London: Oxford University Press.CrossRefGoogle Scholar
Moses, S.N., Ryan, J.D. (2006). A comparison and evaluation of the predictions of relational and conjunctive accounts of hippocampal function. Hippocampus, 16, 43–65.CrossRefGoogle ScholarPubMed
Murphy, K.J., Troyer, A.K., Levine, B., Moscovitch, M. (2008). Episodic, but not semantic, autobiographical memory is reduced in amnestic mild cognitive impairment. Neuropsychologia, 46, 3116–3123.CrossRefGoogle Scholar
Nadel, L. (2008). The hippocampus and context revisited. In S.J.Y. Mizumori (Ed.), Hippocampal place fields: Relevance to learning and memory. Oxford: Oxford University Press.Google Scholar
Nadel, L., Moscovitch, M. (1997). Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinion in Neurobiology, 7, 217–227.CrossRefGoogle ScholarPubMed
Nader, K., Hardt, O. (2009). A single standard for memory: The case for reconsolidation. Nature Reviews Neuroscience, 10, 224–234.CrossRefGoogle ScholarPubMed
Noulhiane, M., Piolino, P., Hasboun, D., Clemenceau, S., Baulac, M., Samson, S. (2007). Autobiographical memory after temporal lobe resection: Neuropsychological and MRI volumetric findings. Brain, 130, 3184–3199.CrossRefGoogle ScholarPubMed
O'Connor, M., Butters, N., Miliotis, P., Eslinger, P., Cermak, L.S. (1992). The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis. Journal of Clinical and Experimental Neuropsychology, 14, 159–178.CrossRefGoogle Scholar
O'Keefe, J., Nadel, L. (1978). The hippocampus as a cognitive map. Oxford: Oxford University Press.Google Scholar
Park, S.A., Hahn, J.H., Kim, J.I., Na, D.L., Huh, K. (2000). Memory deficits after bilateral anterior fornix infarction. Neurology, 54, 1379–1382.CrossRefGoogle ScholarPubMed
Petrican, R., Gopie, N., Leach, L., Chow, T.W., Richards, B., Moscovitch, M. (2010). Recollection and familiarity for public events in neurologically intact older adults and two brain-damaged patients. Neuropsychologia, 48, 945–960.CrossRefGoogle ScholarPubMed
Piolino, P., Desgranges, B., Belliard, S., Matuszewski, V., Lalevee, C., De la Sayette, V., Eustache, F. (2003). Autobiographical memory and autonoetic consciousness: Triple dissociation in neurodegenerative diseases. Brain, 126, 2203–2219.CrossRefGoogle ScholarPubMed
Piolino, P., Desgranges, B., Clarys, D., Guillery-Girard, B., Taconnat, L., Isingrini, M., Eustache, F. (2006). Autobiographical memory, autonoetic consciousness, and self-perspective in aging. Psychology and Aging, 21, 510–525.CrossRefGoogle ScholarPubMed
Piolino, P., Desgranges, B., Eustache, F. (2009). Episodic autobiographical memories over the course of time: Cognitive, neuropsychological and neuroimaging findings. Neuropsychologia, 47, 2314–2329.CrossRefGoogle ScholarPubMed
Poreh, A., Winocur, G., Moscovitch, M., Backon, M., Goshen, E., Ram, Z., Feldman, Z. (2006). Anterograde and retrograde amnesia in a person with bilateral fornix lesions following removal of a colloid cyst. Neuropsychologia, 44, 2241–2248.CrossRefGoogle Scholar
Reed, J.M., Squire, L.R. (1998). Retrograde amnesia for facts and events: Findings from four new cases. Journal of Neuroscience, 18, 3943–3954.CrossRefGoogle ScholarPubMed
Rekkas, P.V., Constable, R.T. (2005). Evidence that autobiographic memory retrieval does not become independent of the hippocampus: An fMRI study contrasting very recent with remote events. Journal of Cognitive Neuroscience, 17, 1950–1961.CrossRefGoogle Scholar
Rempel-Clower, N., Zola-Morgan, S., Squire, L.R., Amaral, D.G. (1996). Three cases of enduring memory impairment following bilateral damage limited to the hippocampal formation. Journal of Neuroscience, 16, 5233–5255.CrossRefGoogle ScholarPubMed
Rosenbaum, R.S., Kohler, S., Schacter, D.L., Moscovitch, M., Westmacott, R., Black, S.E., Tulving, E. (2005). The case of K.C.: Contributions of a memory-impaired person to memory theory. Neuropsychologia, 43, 989–1021.CrossRefGoogle ScholarPubMed
Rosenbaum, R.S., Moscovitch, M., Foster, J.K., Schnyer, D.M., Gao, F., Kovacevic, N., Levine, B. (2008). Patterns of autobiographical memory loss in medial-temporal lobe amnesic patients. Journal of Cognitive Neuroscience, 20, 1490–1506.CrossRefGoogle ScholarPubMed
Rosenbaum, R.S., Winocur, G., Moscovitch, M. (2001). New views on old memories: Re-evaluating the role of the hippocampal complex. Behavioural Brain Research, 127, 183–197.CrossRefGoogle ScholarPubMed
Sackeim, H.E., Prudic, J., Devanand, D.P., Nobler, M.S., Lisanby, S.H., Peyser, S., Clark, J. (2000). A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities. Archives of General Psychiatry, 57, 425–434.CrossRefGoogle ScholarPubMed
Sanders, H.I., Warrington, E.K. (1971). Memory for remote events in amnesic patients. Brain, 94, 61–68.CrossRefGoogle ScholarPubMed
Schnider, A., Bassetti, C., Gutbrod, K., Ozdoba, C. (1995). Very severe amnesia with acute onset after isolated hippocampal damage due to systemic lupus erythematosus. Journal of Neurology, Neurosurgery, and Psychiatry, 59, 644–646.CrossRefGoogle ScholarPubMed
Scoville, W., Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 20, 11–21.CrossRefGoogle ScholarPubMed
Sharon, T., Moscovitch, M., Gilboa, A. (2011). Rapid neocortical acquisition of long-term arbitrary associations independent of the hippocampus. Proceedings of the National Academy of Sciences U S A, 108, 1146–1151.CrossRefGoogle ScholarPubMed
Squire, L.R. (1992). Memory and the hippocampal region: A synthesis of findings with rats, monkeys, and humans. Psychological Review, 99, 195–231.CrossRefGoogle Scholar
Squire, L.R., Alvarez, P. (1995). Retrograde amnesia and memory consolidation: A neurobiological perspective. Current Opinion in Neurobiology, 5, 169–177.CrossRefGoogle ScholarPubMed
Squire, L.R., Bayley, P.J. (2007). The neuroscience of remote memory. Current Opinion in Neurobiology, 17, 185–196.CrossRefGoogle ScholarPubMed
Squire, L.R., Slater, P.C., Chace, P.M. (1975). Retrograde amnesia: Temporal gradient in very long term memory following electroconvulsive therapy. Science, 187, 77–79.CrossRefGoogle ScholarPubMed
Squire, L.R., Wixted, J.T., Clark, R.E. (2007). Recognition memory and the medial temporal lobe: A new perspective. Nature Reviews Neuroscience, 8, 872–883.CrossRefGoogle ScholarPubMed
Squire, L.R., Zola, S.M. (1998). Episodic memory, semantic memory, and amnesia. Hippocampus, 8, 205–211.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Steinvorth, S., Levine, B., Corkin, S. (2005). Medial temporal lobe structures are needed to re-experience remote autobiographical memories: Evidence from H.M. and W.R. Neuropsychologia, 43, 479–496.CrossRefGoogle ScholarPubMed
Takehara, K., Kawahara, S., Kirino, Y. (2003). Time-dependent reorganization of the brain components underlying memory retention in trace eyeblink conditioning. Journal of Neuroscience, 23, 9897–9905.CrossRefGoogle ScholarPubMed
Takehara, K., Nakao, K., Kawahara, S., Matsuki, N., Kirino, Y. (2006). Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. Journal of Neuroscience, 26, 5049–5058.CrossRefGoogle Scholar
Tulving, E., Schacter, D.L., McLachlan, D.R., Moscovitch, M. (1988). Priming of semantic autobiographical knowledge: A case study of retrograde amnesia. Brain and Cognition, 8, 3–20.CrossRefGoogle ScholarPubMed
Victor, M., Agamanolis, D. (1990). Amnesia due to lesions confined to the hippocampus: A clinical-pathologic study. Journal of Cognitive Neuroscience, 2, 246–257.CrossRefGoogle Scholar
Viskontas, I.V., Carr, V.A., Engel, S.A., Knowlton, B.J. (2009). The neural correlates of recollection: Hippocampal activation declines as episodic memory fades. Hippocampus, 19, 265–272.CrossRefGoogle ScholarPubMed
Viskontas, I.V., McAndrews, M.P., Moscovitch, M. (2000). Remote episodic memory deficits in patients with unilateral temporal lobe epilepsy and excisions. Journal of Neuroscience, 20, 5853–5857.CrossRefGoogle ScholarPubMed
Warrington, E.K., Duchen, L.W. (1992). A re-appraisal of a case of persistent global amnesia following right temporal lobectomy: A clinico-pathological study. Neuropsychologia, 30, 437–450.CrossRefGoogle ScholarPubMed
Warrington, E.K., McCarthy, R.A. (1988). The fractionation of retrograde amnesia. Brain and Cognition, 7, 184–200.CrossRefGoogle ScholarPubMed
Westmacott, R., Black, S.E., Freedman, M., Moscovitch, M. (2004). The contribution of autobiographical significance to semantic memory: Evidence from Alzheimer's disease, semantic dementia, and amnesia. Neuropsychologia, 42, 25–48.CrossRefGoogle ScholarPubMed
Westmacott, R., Leach, L., Freedman, M., Moscovitch, M. (2001). Different patterns of autobiographical memory loss in semantic dementia and medial temporal lobe amnesia: A challenge to consolidation theory. Neurocase, 7, 37–55.CrossRefGoogle ScholarPubMed
Westmacott, R., Moscovitch, M. (2003). The contribution of autobiographical significance to semantic memory. Memory and Cognition, 31, 761–774.CrossRefGoogle ScholarPubMed
Wiltgen, B.J., Silva, A.J. (2007). Memory for context becomes less specific with time. Learning and Memory, 14, 313–317.CrossRefGoogle ScholarPubMed
Wiltgen, B.J., Zhou, M., Cai, Y., Balaji, J., Karlsson, M.G., Parivash, S.N., Silva, A.J. (2010). The hippocampus plays a selective role in the retrieval of detailed contextual memories. Current Biology, 20, 1336–1344.CrossRefGoogle Scholar
Winocur, G., Frankland, P.W., Sekeres, M., Fogel, S., Moscovitch, M. (2009). Changes in context-specificity during memory reconsolidation: Selective effects of hippocampal lesions. Learning and Memory, 16, 722–729.CrossRefGoogle ScholarPubMed
Winocur, G., Moscovitch, M., Bontempi, B. (2010). Memory formation and long-term retention in humans and animals: Convergence towards a transformation account of hippocampal-neocortical interactions. Neuropsychologia, 48, 2339–2356.CrossRefGoogle ScholarPubMed
Winocur, G., Moscovitch, M., Fogel, S., Rosenbaum, R.S., Sekeres, M. (2005). Preserved spatial memory after hippocampal lesions: Effects of extensive experience in a complex environment. Nature Neuroscience, 8, 273–275.CrossRefGoogle Scholar
Winocur, G., Moscovitch, M., Rosenbaum, R.S., Sekeres, M. (2010). An investigation of the effects of hippocampal lesions in rats on pre- and postoperatively acquired spatial memory in a complex environment. Hippocampus, 20, 1350–1365.CrossRefGoogle Scholar
Winocur, G., Moscovitch, M., Sekeres, M. (2007). Memory consolidation or transformation: Context manipulation and hippocampal representations of memory. Nature Neuroscience, 10, 555–557.CrossRefGoogle ScholarPubMed
Wolbers, T., Buchel, C. (2005). Dissociable retrosplenial and hippocampal contributions to successful formation of survey representations. Journal of Neuroscience, 25, 3333–3340.CrossRefGoogle ScholarPubMed
Yasuno, F., Hirata, M., Takimoto, H., Taniguchi, M., Nakagawa, Y., Ikejiri, Y., Takeda, M. (1999). Retrograde temporal order amnesia resulting from damage to the fornix. Journal of Neurology, Neurosurgery, and Psychiatry, 67, 102–105.CrossRefGoogle ScholarPubMed
Yonelinas, A.P. (2002). The nature of recollection and familairity: A review of 30 years of research. Journal of Memory and Language, 46, 441–517.CrossRefGoogle Scholar
Yoon, S.S., Na, D.L., Park, K.C. (2008). Retrograde amnesia associated with fornix lymphoma. European Journal of Neurology, 60, 155–158.CrossRefGoogle ScholarPubMed