Hostname: page-component-7c8c6479df-7qhmt Total loading time: 0 Render date: 2024-03-27T06:33:25.025Z Has data issue: false hasContentIssue false

Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood

Published online by Cambridge University Press:  08 June 2011

P. M. Mullin
Affiliation:
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
A. Bray
Affiliation:
Department of Statistics, University of California, Los Angeles, CA, USA
F. Schoenberg
Affiliation:
Department of Statistics, University of California, Los Angeles, CA, USA
K. W. MacGibbon
Affiliation:
Hyperemesis Education and Research Foundation, Leesburg, VA, USA
R. Romero
Affiliation:
Department of Health and Human Services, NICHD, NIH, DHHS, Perinatology Research Branch, Bethesda, MD, and Detroit, MI, USA
T. M. Goodwin
Affiliation:
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
M. S. Fejzo*
Affiliation:
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Medicine, University of California, Los Angeles, CA, USA
*
*Address for correspondence: Dr M. S. Fejzo, Ph.D., 5535 MRL Building. 675 Charles E Young Dr South, LA, CA 90095, USA. (Email mfejzo@mednet.ucla.edu)

Abstract

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, is characterized by long-term maternal stress, undernutrition and dehydration. While maternal stress and malnutrition of pregnancy are linked to poor neonatal outcome and associated with poor adult health, long-term outcome of fetal exposure to HG has never been explored. The purpose of this study is to determine whether long-term emotional and behavioral diagnoses may be associated with fetal exposure to HG. Emotional and behavioral diagnoses of adults born of a pregnancy complicated by HG were compared to diagnoses from non-exposed controls. Offspring exposed to HG in utero were significantly more likely to have a psychological and behavioral disorder (OR = 3.6, P < 0.0001) with diagnoses primarily of depression, bipolar disorder and anxiety. In utero exposure to HG may lead to increased risks of psychological and behavioral disorders in the offspring.

Type
Original Articles
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a

These authors contributed equally.

References

1.Wier, LM, Levit, K, Stranges, E, et al. . HCUP Facts and Figures: Statistics on Hospital-based Care in the United States, 2008, 2010. Agency for Healthcare Research and Quality, Rockville, MD, Retrieved from http://www.hcup-us.ahrq.gov/reports.jsp.Google Scholar
2.Verberg, MF, Gillott, DJ, Al-Fardan, N, Grudzinskas, JG. Hyperemesis gravidarum, a literature review. Hum Reprod Update. 2005; 11, 527539.CrossRefGoogle ScholarPubMed
3.Kallen, B. Hyperemesis during pregnancy and delivery outcome: a registry study. Eur J Obstet Gynecol Reprod Biol. 1987; 26, 291302.CrossRefGoogle ScholarPubMed
4.Zhang, J, Cai, WW. Severe vomiting during pregnancy: antenatal correlates and fetal outcomes. Epidemiology. 1991; 2, 454457.CrossRefGoogle ScholarPubMed
5.Chiossi, G, Neri, I, Cavazutti, M, Basso, G, Fucchinetti, F. HG complicated by Wernicke's encephalopathy: background, case report and review of the literature. Obstet Gynecol Surv. 2006; 61, 255268.CrossRefGoogle Scholar
6.Bailit, JL. HG: epidemiologic findings from a large cohort. Am J Obstet Gynecol. 2005; 193, 811814.CrossRefGoogle Scholar
7.Fairweather, DVI. Nausea and vomiting in pregnancy. Am J Obstet Gynecol. 1968; 102, 135175.CrossRefGoogle ScholarPubMed
8.Goodwin, TM. Hyperemesis gravidarum. Clin Obstet Gynecol. 1998; 41, 597605.CrossRefGoogle ScholarPubMed
9.Fejzo, MS, Poursharif, B, Korst, LM, et al. . Symptoms and pregnancy outcomes associated with extreme weight loss among women with HG. J Womens Health. 2009; 18, 19811987.CrossRefGoogle Scholar
10.Gazmararian, JA, Petersen, R, Jamieson, DJ, et al. . Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002; 100, 94100.Google ScholarPubMed
11.Henderson, BE, Benton, B, Jing, J, Yu, MC, Pike, MC. Risk factors for cancer of the testis in young men. Int J Cancer. 1979; 15, 598602.CrossRefGoogle Scholar
12.Erlandsson, G, Lambe, M, Cnattingius, S, Ekbom, A. Hyperemesis gravidarum and subsequent breast cancer risk. Br J Cancer. 2002; 21, 974976.CrossRefGoogle Scholar
13.Mulder, EJ, Robles de Medina, PG, Huizink, AC, et al. . Prenatal maternal stress: effects on pregnancy and the (unborn) child. Early Hum Dev. 2002; 70, 314.CrossRefGoogle ScholarPubMed
14.Lazinski, M, Shea, A, Steiner, M. Effects of maternal prenatal stress on offspring development: a commentary. Arch Wom Ment Health. 2008; 11, 363375.CrossRefGoogle ScholarPubMed
15.Painter, RC, Roseboom, TJ, Bleker, OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 2005; 20, 345352.CrossRefGoogle Scholar
16.de Rooij, SR, Wouters, H, Yonker, JE, Painter, RC, Roseboom, TJ. Prenatal undernutrition and cognitive function in late adulthood. Proc Natl Acad Sci U S A. 2010; 107, 1688116886.CrossRefGoogle ScholarPubMed
17.Ross, MG, Desai, M. Gestational programming: population survival effects of drought and famine during pregnancy. Am J Physiol Regul Integr Comp Physiol. 2005; 288, 2533.CrossRefGoogle ScholarPubMed
18.Zhang, Y, Cantor, RM, Macgibbon, K, et al. . Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2010; 204, 230.e1230.e7.CrossRefGoogle ScholarPubMed
19.Martin, RP, Wisenbaker, J, Huttunen, MO. Nausea during pregnancy: relation to early childhood temperament and behavior problems at twelve years. J Abnl Child Psych. 1999; 27, 323329.CrossRefGoogle ScholarPubMed
20.Nulman, I, Rovet, J, Barrera, M, et al. . Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin. J Pediatr. 2009; 155, 4550.CrossRefGoogle ScholarPubMed
21.Pirimoglu, ZM, Guzelmeric, K, Alpay, B, et al. . Psychological factors of hyperemesis gravidarum by using the SCL-90-R questionnaire. Clin Exp Obstet Gynecol. 2010; 37, 5659.Google ScholarPubMed
22.Tan, PC, Vani, S, Lim, BK, Omar, SZ. Anxiety and depression in hyperemesis gravidarum: prevalence, risk factors and correlation with clinical severity. Eur J Obstet Gynecol Reprod Biol. 2010; 149, 153158.CrossRefGoogle ScholarPubMed
23.Chiossi, G, Neri, I, Cavazzuti, M, Basso, G, Facchinetti, F. Hyperemesis gravidarum complicated by Wernicke encephalopathy: background, case report, and review of the literature. Obstet Gynecol Surv. 2006; 61, 255268.CrossRefGoogle ScholarPubMed
24.Eventov-Friedman, S, Klinger, G, Shinwell, ES. Third trimester fetal intracranial hemorrhage owing to vitamin K deficiency associated with hyperemesis gravidarum. J Pediatr Hematol Oncol. 2009; 31, 985988.CrossRefGoogle ScholarPubMed
25.Black, MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008; 29(Suppl. 2), S126S131.CrossRefGoogle ScholarPubMed
26.Harms, LR, Eyles, DW, McGrath, JJ, Mackay-Sim, A, Burne, TH. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res. 2008; 187, 343350.CrossRefGoogle ScholarPubMed
27.Calza, A, Sogliano, C, Santoru, F, et al. . Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs. J Neurochem. 2010; 113, 12851295.CrossRefGoogle ScholarPubMed
28.Demir, B, Erel, CT, Haberal, A, et al. . Adjusted leptin level (ALL) is a predictor for hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2006; 124, 193196.CrossRefGoogle ScholarPubMed
29.Aka, N, Atalay, S, Sayharman, S, et al. . Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum. Aust N Z J Obstet Gynaecol. 2006; 46, 274277.CrossRefGoogle ScholarPubMed
30.Fraga-Marques, MC, Moura, EG, Claudio-Neto, S, et al. . Neonatal hyperleptinaemia programmes anxiety-like and novelty seeking behaviours but not memory/learning in adult rats. Horm Behav. 2009; 55, 272279.CrossRefGoogle Scholar
31.Weaver, IC. Shaping adult phenotypes through early life environments. Birth Defects Res C Embryo Today. 2009; 87, 314326.CrossRefGoogle ScholarPubMed
32.Coetzee, RL, Cormack, B, Sadler, L, Bloomfield, FH. Pregnancy and neonatal outcomes following hyperemesis gravidarum. J Dev Orig Health Dis. 2011; 2, 8188.CrossRefGoogle ScholarPubMed
33.Roseboom, TJ, Ravelli, AC, van der Post, JA, Painter, RC. Maternal characteristics largely explain poor pregnancy outcome after hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2011; 156, 5659.CrossRefGoogle ScholarPubMed