Epidemiology and Infection

Table of Contents - September 2011 - Volume 139, Issue 09  

Gastroenteritis

Seroepidemiological studies indicate frequent and repeated exposure to Campylobacter spp. during childhood

C. W. ANGa1 c1, P. F. M. TEUNISa2a3, P. HERBRINKa4, J. KEIJSERa4, Y. H. T. P. VAN DUYNHOVENa5, C. E. VISSERa6 and W. VAN PELTa2

a1 Department of Medical Microbiology and Infection Control, VUMC Amsterdam, The Netherlands

a2 Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

a3 Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

a4 Diagnostic Centre, SSDZ, Delft, The Netherlands

a5 Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

a6 Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

SUMMARY

The annual number of episodes of clinical gastroenteritis caused by Campylobacter spp. in The Netherlands is estimated to be 75 000, i.e. once per 200 person life-years. This number is based on extrapolation of culture results from population-based studies. The number of culture-confirmed cases of Campylobacter infection peaks in the first 3 years of life and again between the ages of 20 and 25 years. The seroepidemiology of Campylobacter describes the relationship between age and exposure to Campylobacter and reflects both symptomatic and asymptomatic infections. Using a validated ELISA system, antibodies to Campylobacter were measured in an age-stratified sample (n=456) of the PIENTER serum collection of the Dutch general population. The seroprevalence of Campylobacter IgG antibodies increased with age, reaching almost 100% at age 20 years. Antibody levels steadily increased with age until young adulthood, suggesting repeated exposure to Campylobacter. In conclusion, seroepidemiological data demonstrated repeated exposures to Campylobacter throughout life, most of which do not lead to clinical symptoms. From young adulthood, >95% of the population in The Netherlands had serological evidence for exposure to Campylobacter.

(Accepted September 15 2010)

(Online publication October 26 2010)

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Correspondence:

c1 Author for correspondence: Dr C. W. Ang, Department of Medical Microbiology and Infection Control, VUMC Amsterdam, The Netherlands. (Email: w.ang@vumc.nl)

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