The Journal of Laryngology & Otology

Online Only Main Article

Rhinocerebral mucormycosis: experience in 14 patients

İ Ketencia1 c1, Y Ünlüa1, H Kayaa1, M A Somdaşa1, O Kontaşa2, M Öztürka3 and A Vurala1

a1 Department of Otorhinolaryngology, Erciyes University, Kayseri, Turkey

a2 Department of Pathology, Erciyes University, Kayseri, Turkey

a3 Department of Radiology, Erciyes University, Kayseri, Turkey


Objective: Mucormycosis is an opportunist, often lethal fungal infection which occurs in immunocompromised patients. We present our experience in 14 patients with this condition.

Patients and methods: A retrospective chart review was conducted for 14 patients treated for rhinocerebral mucormycosis.

Results: Nine patients had diabetes mellitus and six had a haematological malignancy. Nine patients had cutaneous and/or palatal necrosis. Eleven patients were treated with amphotericin B and five with liposomal amphotericin B. Endoscopic sinus surgery was performed in five patients with disease limited to the sinonasal cavity; nine patients underwent more extensive surgery. Five patients with disease limited to the sinonasal cavity survived, while nine patients with widely disseminated disease died. Five of the nine diabetic patients died, as did five of the six patients with haematological malignancy.

Conclusion: Patients with rhinocerebral mucormycosis spreading outside the sinonasal cavity have a poor prognosis.

(Online publication May 13 2011)


c1 Address for correspondence: Dr İbrahim Ketenci, Alpaslan Mah Bahar Cad, Şişli Sitesi A Blok 20/26, 38040 Kayseri, Turkey Fax: +90 352 4379164 E-mail:

Dr İ Ketenci takes responsibility for the integrity of the content of the paper

Competing interests: None declared