The Journal of Laryngology & Otology

Clinical Records

Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations

M Brodliea1a2 c1, S C Barwicka1, K M Wooda3, M C McKeana1 and A Welcha4

a1 Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK

a2 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

a3 Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, UK

a4 Department of Paediatric ENT, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK

Abstract

Objectives: To highlight the clinical importance of inflammatory myofibroblastic tumours of the respiratory tract in children, and to present a case series of three children which illustrates this tumour's variable clinical presentation.

Case history: The series includes: a nine-year-old girl with a diagnosis of juvenile idiopathic arthritis, who presented with finger clubbing and was found to have an inflammatory myofibroblastic tumour in her right upper lobe; a 15-year-old adolescent with a left main stem bronchial inflammatory myofibroblastic tumour, who presented with breathlessness and chest pain; and a 12-year-old girl with a tracheal inflammatory myofibroblastic tumour who presented with stridor. In each case, the tumour was resected surgically.

Conclusion: Inflammatory myofibroblastic tumour are a rare but clinically important and pathologically distinct lesion of the respiratory tract in children. The cases in this series highlight some of the varied clinical presentations of inflammatory myofibroblastic tumours, and illustrate some of this tumour's different anatomical locations within the paediatric respiratory tract.

(Accepted October 15 2010)

(Online publication April 12 2011)

Correspondence:

c1 Address for correspondence: Dr Malcolm Brodlie, SpR in Respiratory Paediatrics, c/o Paediatric Respiratory Secretaries, Old Children's Outpatients, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE7 7DN, UK Fax: +44 191 233 1417 E-mail: m.j.brodlie@ncl.ac.uk

Dr M Brodlie takes responsibility for the integrity of the content of the paper

Competing interests: None declared

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