The Journal of Laryngology & Otology

Clinical Records

Primary cervical tracheal monophasic synovial sarcoma confirmed by SYT–SSX gene rearrangement

C E Corralesa1, G Berrya2 and E J Damrosea1 c1

a1 Department of Otolaryngology, Stanford University, California, USA

a2 Department of Pathology, Stanford University, California, USA


Objective: To review the existing diagnostic modalities and treatment for primary tracheal synovial sarcoma, and to report a case of primary cervical synovial sarcoma arising in the trachea.

Design: Retrospective.

Setting: Head and neck surgery unit at a tertiary university centre.

Patient: One case of primary cervical tracheal monophasic synovial sarcoma diagnosed by SYT–SSX gene rearrangement.

Intervention: This patient underwent surgical resection of the synovial sarcoma, together with tracheal resection and primary anastomosis assisted by laryngeal-releasing manoeuvres, without complication.

Main outcome measures: Clinical, radiographical, pathological and surgical information were collected.

Result: One year post-operatively, there was no evidence of recurrence.

Conclusion: Synovial sarcoma arising in the trachea is very rare. Diagnosis is confirmed by demonstrating the SYT–SSX gene rearrangement. The first-line treatment is surgery.

(Accepted August 24 2010)

(Online publication January 31 2011)


c1 Address for correspondence: Dr Edward J Damrose, Otolaryngology Department, Stanford University, 801 Welch Road, Stanford, CA 94305, USA Fax: + 1 650 725 8502 E-mail:

Dr E J Damrose takes responsibility for the integrity of the content of the paper

Competing interests: None declared