Nutrition Research Reviews

Review Article

Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases

Anne-Laure Tardya1a2a3, Béatrice Morioa1a2a3 c1, Jean-Michel Chardignya1a2a3 and Corinne Malpuech-Brugèrea1a2a3

a1 INRA, UMR 1019 Nutrition Humaine, F-63122 Saint Genès Champanelle, France

a2 Clermont Université, UFR Médecine, UMR 1019 Nutrition Humaine, F-63 000 Clermont-Ferrand, France

a3 CRNH Auvergne, F-63 000 Clermont-Ferrand, France


The various positional isomers of oleic acid (18 : 1Δ9c or 9c-18 : 1) may have distinct biological effects. Detrimental effects of consumption of industrial trans-fatty acids (TFA) (elaidic acid; 18 : 1Δ9t) from partially hydrogenated vegetable oils on CVD risk factors are well documented. In addition, epidemiological data suggest that chronic consumption of industrial sources of TFA could alter insulin sensitivity and predispose for type 2 diabetes. However, intervention studies on this issue have remained inconclusive. Moreover, very little information is available on the effect of natural sources of TFA (vaccenic acid; 18 : 1Δ11t) coming from dairy products and ruminant meat on the development of CVD and type 2 diabetes. The review focuses on the impact of the consumption of ruminant TFA in relation to cardiovascular risk factors, inflammation and type 2 diabetes.

(Online publication February 15 2011)


c1 Corresponding author: Dr Béatrice Morio, fax +33 4 73 60 82 55, email

Abbreviations: I-TFA, industrial trans-fatty acid; R-TFA, ruminant trans-fatty acid; TEI, total energy intake; TFA, trans-fatty acid