Epidemiology and Psychiatric Sciences

Neurobiology of Psychosis

Diffusion imaging studies of white matter integrity in bipolar disorder

M. Bellania1 c1 and P. Brambillaa2a3

a1 Section of Psychiatry and Clinical Psychology, Department of Public Health and Community Medicine, Inter-University Center for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy

a2 DISM, Inter-University Center for Behavioural Neurosciences (ICBN), University of Udine, Udine, Italy

a3 IRCCS “E. Medea” Scientific Institute, Udine, Italy

Diffusion tensor imaging (DTI) is a neuroimaging technique with a potential to elucidate white matter integrity. Recently, it has been used in the field of psychiatry to further understand the pathophysiology of major diseases, including bipolar disorder (BD). This review sought to focus on existing DTI findings on white matter organization in BD.

(Received December 17 2010)

(Revised December 28 2010)

(Accepted December 28 2010)

(Online publication April 04 2011)


This Section of Epidemiology and Psychiatric Sciences regularly appears in each issue of the Journal to describe relevant studies investigating the relationship between neurobiology and psychosocial psychiatry in major psychoses. The aim of these Editorials is to provide a better understanding of the neural basis of psychopathology and clinical features of these disorders, in order to raise new perspectives in every-day clinical practice.

Paolo Brambilla, Section Editor and Michele Tansella, Editor EPS