Psychological Medicine



Original Article

Young males have a higher risk of developing schizophrenia: a Danish register study


ANNE THORUP a1c1, BERIT LINDUM WALTOFT a2, CARSTEN B. PEDERSEN a2, PREBEN B. MORTENSEN a2 and MERETE NORDENTOFT a1
a1 Department of Psychiatry, Bispebjerg Hospital, Copenhagen NV, Denmark
a2 National Centre for Register-based Research, University of Aarhus, Aarhus C, Denmark

Article author query
thorup a   [PubMed][Google Scholar] 
waltoft bl   [PubMed][Google Scholar] 
pedersen cb   [PubMed][Google Scholar] 
mortensen pb   [PubMed][Google Scholar] 
nordentoft m   [PubMed][Google Scholar] 

Abstract

Background. Gender differences are commonly reported in schizophrenia research, especially with regard to age at onset. Few studies have reported the age- and gender-specific incidence of schizophrenia in people aged up to 71 years, and no studies have reported the cumulative incidence of schizophrenia in people aged up to 71 years.

Method. Two cohorts were established by linking data from the Danish Civil Registration System (DCRS) with data from the Danish Psychiatric Central Register (DPCR), which covers all incident cases of schizophrenia from 15 to 71 years. We estimated the gender- and age-specific incidence rates of schizophrenia for people aged up to 71 years. We also estimated the cumulative incidences.

Results. The incidence rates for males significantly exceeded those for females in the age range from 17 to 40 years. By their 72nd birthday, 1·59% of males and 1·17% of females had developed schizophrenia.

Conclusion. Male sex is a major risk factor for the development of schizophrenia.


Correspondence:
c1 Bispebjerg Hospital, Department of Psychiatry, Bispebjerg Bakke 23, DK 2400 NV, Denmark. (Email: atv@dadlnet.dk)


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