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Pre- and postnatal determinants of childhood body size: cohort and sibling analyses

Published online by Cambridge University Press:  02 March 2011

M. B. Terry*
Affiliation:
Department of Epidemiology, Columbia University Medical Center, Mailman School of Public Health, New York, NY, USA The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University, Mailman School of Public Health and the New York State Psychiatric Institute, New York, NY, USA
Y. Wei
Affiliation:
Department of Biostatistics, Columbia University, Mailman School of Public Health, New York, NY, USA
D. Esserman
Affiliation:
Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA Department of Medicine, Division of General Medicine and Clinical Epidemiology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
I. W. McKeague
Affiliation:
Department of Biostatistics, Columbia University, Mailman School of Public Health, New York, NY, USA
E. Susser
Affiliation:
Department of Epidemiology, Columbia University Medical Center, Mailman School of Public Health, New York, NY, USA The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University, Mailman School of Public Health and the New York State Psychiatric Institute, New York, NY, USA Departmant of Psychiatry, Columbia University Medical Center, New York, NY, USA
*
*Address for correspondence: M. B. Terry, PhD, Department of Epidemiology, Columbia University Medical Center, Mailman School of Public Health, 722 West 168th Street, New York, NY 10032, USA. (Email mt146@columbia.edu)

Abstract

Growing evidence suggests obesity may have its roots in early life but it is still uncertain whether prenatal factors operate primarily though altering early infant growth. It is also still unclear if rapid growth during selected time periods is more important than other time periods in predicting future body size. Using prospectively collected data on 20,523 participants born from 1959 to 1966 (10,327 boys; 10,196 girls) of the Collaborative Perinatal Project, we investigated the associations between pre- and postnatal factors and childhood body size at age 7 years and compared these associations across linear, logistic and quantile regression models. Maternal body mass index (BMI), maternal pregnancy weight gain, birth weight and postnatal weight change for three time periods (birth to 4 months; 4–12 months; 1–4 years) were all positively and independently associated with BMI at age 7 years. Rapid growth during each time period had a similar association BMI at age 7 years. For example, a 10-percentile increase in weight increased the probability of being overweight at age 7 years by approximately two-fold regardless of time period (OR = 1.8–2.2 for boys and girls). Using same-sex siblings (n = 571 boy sets; n = 651 girl sets) from the same cohort, we observed that siblings with higher BMI at age 7 years than their same-sex siblings were more likely to have higher maternal pregnancy weight gain, higher maternal pre-pregnancy BMI, higher birth weight and increased rate of weight gain during the three time periods. These consistent findings both from the overall cohort and the sibling analyses suggest that there are multiple, rather than specific critical periods of influence shaping childhood body size.

Type
Original Articles
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

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References

1. Troiano, RP, Flegal, KM, Kuczmarski, RJ, Campbell, SM, Johnson, CL. Overweight prevalence and trends for children and adolescents. The National Health and Nutrition Examination Surveys, 1963 to 1991. Arch Pediatr Adolesc Med. 1995; 149, 10851091.CrossRefGoogle ScholarPubMed
2. Hedley, AA, Ogden, CL, Johnson, CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA. 2004; 291, 28472850.CrossRefGoogle ScholarPubMed
3. Whitaker, RC, Wright, JA, Pepe, MS, Seidel, KD, Dietz, WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997; 337, 869873.CrossRefGoogle ScholarPubMed
4. Guo, SS, Wu, W, Chumlea, WC, Roche, AF. Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr. 2002; 76, 653658.CrossRefGoogle ScholarPubMed
5. Strauss, RS. Effects of the intrauterine environment on childhood growth. Br Med Bull. 1997; 53, 8195.CrossRefGoogle ScholarPubMed
6. Oken, E, Gillman, MW. Fetal origins of obesity. Obes Res. 2003; 11, 496506.CrossRefGoogle ScholarPubMed
7. Whitaker, RC, Dietz, WH. Role of the prenatal environment in the development of obesity. J Pediatr. 1998; 132, 768776.CrossRefGoogle ScholarPubMed
8. Monteiro, PO, Victora, CG. Rapid growth in infancy and childhood and obesity in later life – a systematic review. Obes Rev. 2005; 6, 143154.CrossRefGoogle ScholarPubMed
9. Ong, KK. Size at birth, postnatal growth and risk of obesity. Horm Res. 2006; 65(Suppl. 3), 6569.Google ScholarPubMed
10. Gillman, MW, Kleinman, K. Invited commentary: antecedents of obesity-analysis, interpretation, and use of longitudinal data. Am J Epidemiol. 2007; 166, 1416.CrossRefGoogle Scholar
11. Broman, S. The collaborative perinatal project: an overview. In Handbook of Longitudinal Research, Vol I (eds. Mednick SA, Harway M, Finello KM), 1984; pp. 185227. Praeger Publishers, New York.Google Scholar
12. Hemachandra, AH, Howards, PP, Furth, SL, Klebanoff, MA. Birth weight, postnatal growth, and risk for high blood pressure at 7 years of age: results from the Collaborative Perinatal Project. Pediatrics. 2007; 119, e1264e1270.CrossRefGoogle ScholarPubMed
13. Benirschke, K. Examination of the placenta. Obstet Gynecol. 1961; 18, 309333.Google Scholar
14. Koenker, R, Hallock, K. Quantile regression. J Econ Persp. 2001; 51, 143156.CrossRefGoogle Scholar
15. Terry, MB, Wei, Y, Esserman, D. Maternal, birth, and early life influences on adult body size in women. Am J Epidemiol. 2007; 166, 513.CrossRefGoogle ScholarPubMed
16. Hosmer, DW, Lemeshow, S. Applied Logistic Regression, 1989. John Wiley & Sons: New York.Google Scholar
17. Terry, MB, Wei, Y, Esserman, D. Response to invited commentary on maternal, birth, and early life influences on adult body size in women. Am J Epidemiol. 2007; 166, 1718.CrossRefGoogle Scholar
18. Cole, TJ. Conditional reference charts to assess weight gain in British infants. Arch Dis Child. 1995; 73, 816.CrossRefGoogle ScholarPubMed
19. Wei, Y, Pere, A, Koenker, R, He, X. Quantile regression methods for reference growth charts. Stat Med. 2006; 25, 13691382.CrossRefGoogle ScholarPubMed
20. Wei, Y, He, X. Conditional growth chart. Ann Stat. 2006; 34, 20692097.CrossRefGoogle Scholar
21. Koenker, R, Machado, JAF. Goodness of fit and related inference processes for quantile regression. J Am Stat Assoc. 1999; 94, 12961310.CrossRefGoogle Scholar
22. Binkin, NJ, Yip, R, Fleshood, L, Trowbridge, FL. Birth weight and childhood growth. Pediatrics. 1988; 82, 828834.CrossRefGoogle ScholarPubMed
23. Li, C, Goran, MI, Kaur, H, Nollen, N, Ahluwalia, JS. Developmental trajectories of overweight during childhood: role of early life factors. Obesity (Silver Spring). 2007; 15, 760771.CrossRefGoogle ScholarPubMed
24. Salsberry, PJ, Reagan, PB. Dynamics of early childhood overweight. Pediatrics. 2005; 116, 13291338.CrossRefGoogle ScholarPubMed
25. Eid, EE. Follow-up study of physical growth of children who had excessive weight gain in first six months of life. Br Med J. 1970; 2, 7476.CrossRefGoogle ScholarPubMed
26. Tanaka, T, Matsuzaki, A, Kuromaru, R, et al. Association between birthweight and body mass index at 3 years of age. Pediatr Int. 2001; 43, 641646.CrossRefGoogle ScholarPubMed
27. Stettler, N, Zemel, BS, Kumanyika, S, Stallings, VA. Infant weight gain and childhood overweight status in a multicenter, cohort study. Pediatrics. 2002; 109, 194199.CrossRefGoogle Scholar
28. Dennison, BA, Edmunds, LS, Stratton, HH, Pruzek, RM. Rapid infant weight gain predicts childhood overweight. Obesity (Silver Spring). 2006; 14, 491499.CrossRefGoogle ScholarPubMed
29. Charney, E, Goodman, HC, McBride, M, Lyon, B, Pratt, R. Childhood antecedents of adult obesity. Do chubby infants become obese adults? N Engl J Med. 1976; 295, 69.CrossRefGoogle ScholarPubMed
30. Stettler, N, Stallings, VA, Troxel, AB, et al. Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation. 2005; 111, 18971903.CrossRefGoogle ScholarPubMed
31. Stettler, N, Kumanyika, SK, Katz, SH, Zemel, BS, Stallings, VA. Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans. Am J Clin Nutr. 2003; 77, 13741378.CrossRefGoogle Scholar
32. Stettler, N, Tershakovec, AM, Zemel, BS, et al. Early risk factors for increased adiposity: a cohort study of African American subjects followed from birth to young adulthood. Am J Clin Nutr. 2000; 72, 378383.CrossRefGoogle ScholarPubMed
33. Kuh, D, Ben-Sholmo, Y. A Life Course Approach to Chronic Disease Epidemiology, 2004. Oxford University Press, New York, NY.CrossRefGoogle Scholar
34. Mei, Z, Grummer-Strawn, LM, Thompson, D, Dietz, WH. Shifts in percentiles of growth during early childhood: analysis of longitudinal data from the California child health and development study. Pediatrics. 2004; 113, e617e627.CrossRefGoogle ScholarPubMed
35. Rolland-Cachera, MF, Deheeger, M, Bellisle, F, et al. Adiposity rebound in children: a simple indicator for predicting obesity. Am J Clin Nutr. 1984; 39, 129135.CrossRefGoogle ScholarPubMed
36. Kinra, S, Baumer, JH, Davey Smith, G. Early growth and childhood obesity: a historical cohort study. Arch Dis Child. 2005; 90, 11221127.CrossRefGoogle ScholarPubMed
37. Singhal, A, Lucas, A. Early origins of cardiovascular disease: is there a unifying hypothesis. Lancet. 2004; 363, 16421645.CrossRefGoogle Scholar
38. Gluckman, PD. Developmental Origins of Health and Disease, 2006. Cambridge University Press: New York.CrossRefGoogle Scholar
39. Stunkard, AJ, Harris, JR, Pedersen, NL, McClearn, GE. The body-mass index of twins who have been reared apart. N Engl J Med. 1990; 322, 14831487.CrossRefGoogle ScholarPubMed
40. Allison, DB, Paultre, F, Heymsfield, SB, Pi-Sunyer, FX. Is the intra-uterine period really a critical period for the development of adiposity? Int J Obes Relat Metab Disord. 1995; 19, 397402.Google ScholarPubMed
41. Loos, RJ, Beunen, G, Fagard, R, Derom, C, Vlietinck, R. Birth weight and body composition in young women: a prospective twin study. Am J Clin Nutr. 2002; 75, 676682.CrossRefGoogle ScholarPubMed
42. Cole, TJ, Green, PJ. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992; 11, 13051319.CrossRefGoogle ScholarPubMed
43. Wei, Y, Pere, A, Koenker, R, He, X. Quantile regression methods for reference growth charts. Stat Med. 2006; 25, 13691382.CrossRefGoogle ScholarPubMed
44. Kaufman, JS, Maclehose, RF, Kaufman, S. A further critique of the analytic strategy of adjusting for covariates to identify biologic mediation. Epidemiol Perspect Innov. 2004; 1, 4.CrossRefGoogle ScholarPubMed
45. Ong, KK, Ahmed, ML, Emmett, PM, Preece, MA, Dunger, DB. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000; 320, 967971.CrossRefGoogle ScholarPubMed
46. Ekelund, U, Ong, K, Linne, Y, et al. Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm weight development study (SWEDES). Am J Clin Nutr. 2006; 83, 324330.CrossRefGoogle ScholarPubMed
47. Blair, NJ, Thompson, JM, Black, PN, et al. Risk factors for obesity in 7-year-old European children: the Auckland birthweight collaborative study. Arch Dis Child. 2007; 92, 866871.CrossRefGoogle ScholarPubMed
48. Eisenmann, JC. Secular trends in variables associated with the metabolic syndrome of North American children and adolescents: a review and synthesis. Am J Hum Biol. 2003; 15, 786794.CrossRefGoogle ScholarPubMed
49. Chike-Obi, U, David, RJ, Coutinho, R, Wu, SY. Birth weight has increased over a generation. Am J Epidemiol. 1996; 144, 563569.CrossRefGoogle ScholarPubMed
50. Martin, JA, Hamilton, BE, Sutton, PD, et al. Births: final data for 2003. Natl Vital Stat Rep. 2005; 54, 1116.Google ScholarPubMed
51. Chen, A, Pennell, ML, Klebanoff, M, Rogan, WJ, Longnecker, MP. Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years. Int J Epidemiol. 2006; 35, 121130.CrossRefGoogle ScholarPubMed
52. Baptiste-Roberts, K, Salafia, BM, Nicholson, W, Duggan, A, Wang, NY, Brancati, FL. Gross placental measures and childhood growth. J Matern Fetal Neonatal Med. 2009; 22, 1323.CrossRefGoogle ScholarPubMed
53. Gillman, MW, Rifas-Shiman, , Kleinman, K, Oken, E, Rich-Edwards, J, Taveras, EM. Developmental Origens of Childhood Overweight: Potential for Public Health Impact. Obesity. 2008; 16511656.CrossRefGoogle Scholar