Psychological Medicine

Original Articles

Neural correlates of trait anxiety in fear extinction

C. Sehlmeyera1, U. Dannlowskia1, S. Schöninga1a2, H. Kugela3, M. Pykaa1, B. Pfleiderera3, P. Zwitserlooda4, H. Schiffbauera3a5, W. Heindela3, V. Arolta1 and C. Konrada1a2a6 c1

a1 Department of Psychiatry, University Hospital of Muenster, Germany

a2 Interdisciplinary Center for Clinical Research, University Hospital of Muenster, Germany

a3 Department of Clinical Radiology, University Hospital of Muenster, Germany

a4 Department of Psychology, University of Muenster, Germany

a5 Department of Radiology, University Hospital of Bonn, Germany

a6 Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Germany

Abstract

Background Fear conditioning involves the amygdala as the main neural structure for learning fear responses whereas fear extinction mainly activates the inhibitory prefrontal cortex (PFC). In this study we investigated whether individual differences in trait anxiety affect amygdala and dorsal anterior cingulate cortex (dACC) activation during fear conditioning and extinction.

Method Thirty-two healthy subjects were investigated by functional magnetic resonance imaging (fMRI) at 3 T while performing a cued fear-conditioning task. All participants completed the trait version of the State-Trait Anxiety Inventory (STAI-T). Activations of the amygdala and the dACC were examined with respect to the effects of trait anxiety.

Results Analysis of the fMRI data demonstrated enhanced activation in fear-related brain areas, such as the insula and the ACC, during both fear conditioning and extinction. Activation of the amygdala appeared only during the late acquisition phase whereas deactivation was observed during extinction. Regression analyses revealed that highly trait-anxious subjects exhibited sustained amygdala activation and reduced dACC involvement during the extinction of conditioned responses.

Conclusions This study reveals that high levels of trait anxiety are associated with both increased amygdala activation and reduced dACC recruitment during the extinction of conditioned fear. This hyper-responsitivity of the amygdala and the deficient cognitive control during the extinction of conditioned fear in anxious subjects reflect an increased resistance to extinct fear responses and may thereby enhance the vulnerability to developing anxiety disorders.

(Received December 21 2009)

(Revised May 02 2010)

(Accepted May 10 2010)

(Online publication June 16 2010)

Correspondence

c1 Address for correspondence: C. Konrad, M.D., Department of Psychiatry, University of Marburg, Rudolf-Bultmann-Straße 8, D-35039 Marburg, Germany. (Email: Carsten.Konrad@med.uni-marburg.de)

Footnotes

† These authors contributed equally as joint first authors.

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