a1 Department of Otorhinolaryngology, Kecioren Training and Research Hospital, Ankara, Turkey
a2 Department of Pathology, Kecioren Training and Research Hospital, Ankara, Turkey
a3 Department of Biology, Kırıkkale University, Turkey
Objective: This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal.
Materials and methods: A prospective, case–control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human β-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared.
Results: There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p < 0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p > 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human β-defensin-3 or LL-37 cathelicidin.
Conclusion: Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis.
(Accepted June 04 2010)
(Online publication October 29 2010)
c1 Address for correspondence: Dr Baran Acar, Department of Otorhinolaryngology, Kecioren Training and Research Hospital, Pinarbasi mahallesi Sanatoryum caddesi Ardahan sok no 1, Kecioren 06310, Ankara, Turkey Fax: + 90 312 356 90 22 E-mail: email@example.com
Dr B Acar takes responsibility for the integrity of the content of the paper
Competing interests: None declared