Parasitology



Sudan: the possible original focus of visceral leishmaniasis


F.  PRATLONG  a1, J.  DEREURE  a1, B.  BUCHETON  a2, S.  EL-SAFI  a3, A.  DESSEIN  a2, G.  LANOTTE  a1 and J. P.  DEDET  a1 c1
a1 Laboratoire de Parasitologie et Centre National de Référence des Leishmanioses, CHU de Montpellier, 163 Rue Auguste-Broussonet, 34090 Montpellier, France
a2 Immunologie et Génétique des Maladies parasitaires, INSERM U 399, Faculté de Médecine, 27 Boulevard Jean-Moulin, 13385 Marseille Cedex 05, France
a3 Institute for Tropical Medicine, P.O. Box 1304, Khartoum, Sudan

Article author query
pratlong f   [PubMed][Google Scholar] 
dereure j   [PubMed][Google Scholar] 
bucheton b   [PubMed][Google Scholar] 
el-safi s   [PubMed][Google Scholar] 
dessein a   [PubMed][Google Scholar] 
lanotte g   [PubMed][Google Scholar] 
dedet j   [PubMed][Google Scholar] 

Abstract

Fifty-two Leishmania strains, obtained from human patients and dogs in a visceral leishmaniasis focus in Sudan, were characterized by isoenzyme electrophoresis (15 enzymes). The phylogenetic analysis showed that the 7 Leishmania zymodemes obtained hold ancestral positions on the phylogenetic tree, supporting the hypothesis of an East African origin of visceral leishmaniasis.

(Received August 11 2000)
(Revised January 12 2000)
(Accepted January 14 2000)


Key Words: Leishmania; systematics; phylogeny; Leishmania donovani; Leishmania archibaldi; Leishmania infantum; Sudan.

Correspondence:
c1 Corresponding author: Laboratoire de Parasitologie, 163 rue Auguste-Broussonet, 34090 Montpellier, France. Tel: +334 67 63 27 51. Fax: +334 67 63 00 49. E-mail: parasito@sc.univ-montp1.fr


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