Parasitology



Review Article

Biology of the schistosome lung-stage schistosomulum


G. N. GOBERT a1c1, M. CHAI a1 and D. P. McMANUS a1
a1 Molecular Parasitology Laboratory, Infectious Diseases and Immunology Division and Australian Centre for International Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006 Australia

Article author query
gobert gn   [PubMed][Google Scholar] 
chai m   [PubMed][Google Scholar] 
mcmanus dp   [PubMed][Google Scholar] 

Abstract

Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune response with the parasite surface, (3) glucose uptake mechanisms, and (4) defining the transcriptional profiles of lung-stage schistosomula compared with other developmental stages using microarrays. The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical studies.

(Received June 30 2006)
(Revised September 8 2006)
(Accepted September 11 2006)
(Published Online November 17 2006)


Key Words: schistosome; lung schistosomula; immune evasion; in vitro model.

Correspondence:
c1 Tel: +61 7 3362 0406. Fax: +61 7 3362 0104. E-mail: geoffG@qimr.edu.au


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