Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

MRS Proceedings

MRS Proceedings / Volume 1241 / 2009
Copyright © Materials Research Society 2010
DOI: http://dx.doi.org/10.1557/PROC-1241-XX05-03 (About DOI)

Table of Contents - Volume 1241 - Symposium XX – Biological Imaging and Sensing Using Nanoparticle Assemblies

Editors : A. Alexandrou, J. Cheon, H. Mattoussi, V. Rotello

Articles

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2009 MRS Fall Meeting.

Article author query
tremel w [Google Scholar]
shukoor mi [Google Scholar]
natalio f [Google Scholar]
schladt t [Google Scholar]
barz m [Google Scholar]
tahir mn [Google Scholar]
weber s [Google Scholar]
zentel r [Google Scholar]
schreiber lm [Google Scholar]
brieger j [Google Scholar]
schröder hc [Google Scholar]
müller w [Google Scholar]

Wolfgang Tremel^a1, Mohammed Ibrahim Shukoor^a2, Filipe Natalio^a3, Thomas Schladt^a4, Matthias Barz^a5, Muhammad Nawaz Tahir^a6, Stefan Weber^a7, Rudolf Zentel^a8, Laura Maria Schreiber^a9, Jürgen Brieger^a10, Heinz Christoph Schröder^a11 and Werner Müller^a12

^a1shukoor@uni-mainz.de, Universität Mainz, Institut für Anorganische Chemie und Analytische Chemie, Mainz, Germany

^a2natalio@uni-mainz.de, Universität Mainz, Institut für Physiologische Chemie, Mainz, Germany

^a3schladt@uni-mainz.de, Germany

^a4barz@uni-mainz.de, Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Mainz, Germany

^a5tahir@uni-mainz.de, Germany

^a6stefanw@uni-mainz.de, Klinikum der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Mainz, Germany

^a7zentel@uni-mainz.de, Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Mainz, Germany

^a8lschreib@uni-mainz.de, Klinikum der Johannes Gutenberg-Universität Mainz, Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Mainz, Germany

^a9brieger@hno.klinik.uni-mainz.de, Klinikum der Johannes Gutenberg-Universität Mainz, HNO Klinik, Labor für Tumorbiologie, Mainz, Germany

^a10hschroed@uni-mainz.de, Germany

^a11wmueller@uni-mainz.de, Germany

^a12tremel@uni-mainz.de, Universität Mainz, Institut für Anorganische Chemie und Analytische Chemie, Duesbergweg 10-14, Mainz, 55099, Germany, +49 6131 3925135, +49 6131 3925605

Abstract

Initiation of pathways that lead to proliferation and chemoresistance by Toll-like receptors (TLRs) is an important factor in cancer progression. Here, we show the response of human cancer cells to TLR signaling inevitably linked to tumor biology. The approach is based on tailored multifunctional magnetic nanoparticles equipped with pathogen-derived ligands (CpG) functioning as TLR agonists (molecular component) to investigate the impact of transcription factor immune activation on human cancer cells. Magnetic nanoparticles (MnO and bifunctional Au-MnO) particles were covalently coated with a multifunctional polymer, displaying no cytotoxicity, to being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR 9. Both, the particle and the nucleic acid are tagged with fluorescent markers for simultaneous visualization inside the cell. Apart from optical imaging, the magnetism of the particles also allows magnetic resonance imaging of organisms.

(Received November 29 2009)

(Accepted May 04 2010)

Key Words

nanoscale;
magnetic;
biomedical

Blog This Article

Blog This Article :

Highlight all

<div style="background: #FFFFFF; margin: 0 10px 10px 0; padding: 0 10px 0 0; text-align: left; font-family: Arial, Helvetica, sans-serif; line-height: 1em;"><div style="font-size: 11px; padding: 0px 0px 10px 0px; font-weight:bold; color: #045989;">Functionalized Magnetic Nanoparticles for Selective Targeting of Cells</div><div style="font-size: 11px;"><b>
					Wolfgang Tremel,
					Mohammed Ibrahim Shukoor,
					Filipe Natalio,
					Thomas Schladt,
					Matthias Barz,
					Muhammad Nawaz Tahir,
					Stefan Weber,
					Rudolf Zentel,
					Laura Maria Schreiber,
					Jürgen Brieger,
					Heinz Christoph Schröder
					 and Werner Müller (2009).	</b><br /><a href="http://journals.cambridge.org/action/displayJournal?jid=OPL">MRS Proceedings</a>, <a href="http://journals.cambridge.org/action/displayJournal?jid=OPL&volumeId=1241&bVolume=y#loc1241>
				 ">Volume 1241</a>, 20091241-XX05-03<br/>
<a href="http://journals.cambridge.org/action/displayAbstract?aid=7972332">http://journals.cambridge.org/action/displayAbstract?aid=7972332</a></div></div>

The code will display like this

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

Wolfgang Tremel, Mohammed Ibrahim Shukoor, Filipe Natalio, Thomas Schladt, Matthias Barz, Muhammad Nawaz Tahir, Stefan Weber, Rudolf Zentel, Laura Maria Schreiber, Jürgen Brieger, Heinz Christoph Schröder and Werner Müller 2009
MRS Proceedings, ,Volume1241, 20091241-XX05-03
http://journals.cambridge.org/abstract_S1946427400021813

Welcome to Cambridge Journals Online

MRS Proceedings

Articles

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2009 MRS Fall Meeting.

Wolfgang Tremela1, Mohammed Ibrahim Shukoora2, Filipe Natalioa3, Thomas Schladta4, Matthias Barza5, Muhammad Nawaz Tahira6, Stefan Webera7, Rudolf Zentela8, Laura Maria Schreibera9, Jürgen Briegera10, Heinz Christoph Schrödera11 and Werner Müllera12

Wolfgang Tremel^a1, Mohammed Ibrahim Shukoor^a2, Filipe Natalio^a3, Thomas Schladt^a4, Matthias Barz^a5, Muhammad Nawaz Tahir^a6, Stefan Weber^a7, Rudolf Zentel^a8, Laura Maria Schreiber^a9, Jürgen Brieger^a10, Heinz Christoph Schröder^a11 and Werner Müller^a12