MRS Proceedings

Table of Contents - Volume  1209  - Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology  

Editors : S.S. Mao, L. Merhari, J. van Schijndel, L. Tsakalakos, R. Hurt, H. Liu, T.J. Webster

Articles

Nanoengineering of Immune Cell Function

2009 MRS Fall Meeting.

Keyue Shena1, Michael C Milonea2, Michael L. Dustina3 and Lance Cameron Kama4

a1 ks2274@columbia.edu, Columbia University, Biomedical Engineering, New York, New York, United States

a2 milonem@uphs.upenn.edu, University of Pennsylvania School of Medicine, Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, United States

a3 Michael.Dustin@med.nyu.edu, New York School of Medicine, Skirball Institute of Biomolecular Medicine, New York, New York, United States

a4 lk2141@columbia.edu, Columbia University, Biomedical Engineering, New York, New York, United States

Abstract

T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.

(Received January 19 2010)

(Accepted February 18 2010)

Key Words

  • biomaterial;
  • biomedical;
  • nanoscale
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