MRS Proceedings

Table of Contents - Volume  1209  - Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology  

Editors : S.S. Mao, L. Merhari, J. van Schijndel, L. Tsakalakos, R. Hurt, H. Liu, T.J. Webster


Nanoengineering of Immune Cell Function

2009 MRS Fall Meeting.

Keyue Shena1, Michael C Milonea2, Michael L. Dustina3 and Lance Cameron Kama4

a1, Columbia University, Biomedical Engineering, New York, New York, United States

a2, University of Pennsylvania School of Medicine, Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, United States

a3, New York School of Medicine, Skirball Institute of Biomolecular Medicine, New York, New York, United States

a4, Columbia University, Biomedical Engineering, New York, New York, United States


T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.

(Received January 19 2010)

(Accepted February 18 2010)

Key Words

  • biomaterial;
  • biomedical;
  • nanoscale