Proceedings of the Nutrition Society

Reproduction and Development Group Symposium on ‘Feeding, nurture and childhood development’

Nutritional deficiencies and later behavioural development

S. M. Grantham-McGregora1 c1, S. P. Walkera2 and S. Changa2

a1 Centre for International Child Health, Institute of Child Health, 30 Guilford St, London WCI IEH, UK

a2 Tropical Metabolism Research Unit, University of the West Indies, Jamaica

Abstract

The literature on the long-term effects of nutritional deficiencies in early life is reviewed. The severity and duration of the deficiency, the stage of the children’s development, the biological condition of the children and the socio-cultural context may all modify the effect. There is substantial evidence that reduced breast-feeding, small-for-gestational-age birth weight, Fe and I deficiency, and protein-energy malnutrition (PEM) are associated with long-term deficits in cognition and school achievement. However, all these conditions are associated with poverty and poor health, which may account for the association. It is difficult to establish that the long-term relationship is causal, as it requires a randomized treatment trial with long-term follow-up. Such studies are only available for I deficiency in utero and early childhood PEM. Results from these studies indicate that I deficiency has a long-term effect and PEM probably has a long-term effect.

Correspondence:

c1 *Corresponding author: Dr S. M. Grantham-McGregor, fax +44 (0)207 831 0488, email smcgregor@ich.ucl.ac.uk