Cardiology in the Young

Brief Reports

Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy

Aris Lacisa1 and Andrejs Erglisa2 c1

a1 Latvian Centre of Pediatric Cardiology, Children’s Hospital, Riga, Latvia

a2 Latvian Centre of Cardiology, Paula Stradina Clinical University Hospital, Riga, Latvia

Abstract

Almost half of the children with symptomatic dilated cardiomyopathy receive a transplant or die within 2 years; however, cardiac stem cell transplantation has become a promising therapeutic option. The present case demonstrates for the first time, to our knowledge, the intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill 4-month-old child with severe dilated cardiomyopathy. Left ventricular ejection fraction increased from 20% before stem cell transplantation to 41% at 4 months of follow-up.

(Received December 10 2009)

(Accepted August 22 2010)

(Online publication October 27 2010)

Correspondence:

c1 Correspondence to: Prof. A. Erglis, MD, PhD, Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu 13, LV-1002, Riga, Latvia. Tel: +371 67069379; Fax: +371 67069548; E-mail: a.a.erglis@stradini.lv

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