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Metabolic abnormalities and wasting in human immunodeficiency virus infection

Published online by Cambridge University Press:  28 February 2007

Derek C. Macallan*
Affiliation:
Division of Infectious Diseases, St George's Hospital Medical School, Cranmer Terrace, London SWI7 ORE, UK
*
Corresponding author: Dr D. C. Macallan, fax +44 (0) 181 725 3487, email macallan@sghms.ac.uk
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Abstract

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Type
Sir David Cuthbertson Prize Medal Lecture
Copyright
Copyright © The Nutrition Society 1998

References

Berneis, K, Leisibach, A, Tietz, A, Bassatti, S, Battegay, M & Keller, U (1997) Whole body protein turnover in HIV-infected patients. Nutrition 13, 269 Abstr.CrossRefGoogle Scholar
Cuthbertson, DP (1930) The disturbance of metabolism produced by bony and non-bony injury, with notes on certain abnormal conditions of bone. Biochemical Journal 24, 12441263.CrossRefGoogle ScholarPubMed
Cuthbertson, DP (1932) Observations on disturbance of metabolism produced by injury to the limbs. Quarterly Journal of Medicine 1, 233246.Google Scholar
Cuthbertson, DP (1942) Post-shock metabolic response. Lancet i, 433436.CrossRefGoogle Scholar
Cuthbertson, DP (1954) Interrelationship of metabolic changes consequent to injury. British Medical Bulletin 10, 3337.CrossRefGoogle ScholarPubMed
Garlick, PJ, Clugston, GA, Swick, RW & Waterlow, JC (1980) Diurnal pattern of protein and energy metabolism in man. American Journal of Clinical Nutrition 33, 19831986.CrossRefGoogle ScholarPubMed
Grunfeld, C, Kotler, DP, Hamadeh, R, Tiemey, AR, Wang, J & Pierson, RN (1989) Hypertriglyceridemia in the Acquired Immunodeficiency Syndrome. American Journal of Medicine 86, 2731.CrossRefGoogle ScholarPubMed
Grunfeld, C, Pang, M, Doerrler, W, Shigenaga, JK, Jensen, P & Feingold, KR (1992 a) Lipids, lipoproteins, triglyceride clearance, and cytokines in Human Immunodeficiency Virus infection and the Acquired Immunodeficiency Syndrome. Journal of Clinical Endocrinology and Metabolism 74, 10451052.Google ScholarPubMed
Grunfeld, C, Pang, M, Shigenaga, JK, Jensen, P, Lallone, R, Friedman, J & Feingold, KR (1996) Serum leptin levels in the Acquired Immunodeficiency Syndrome. Journal of Clinical Endocrinology and Metabolism 81, 43424346.Google ScholarPubMed
Grunfeld, C, Pang, M, Shimizu, L, Shigenaga, JK, Jensen, P & Feingold, KR (1992 b) Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. American Journal of Clinical Nutrition 55, 455460.CrossRefGoogle ScholarPubMed
Hellerstein, MK, Grunfeld, C, Wu, K, Christiansen, M, Kaempfer, S, Kletke, C & Shackleton, CHL (1993) Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. Journal of Clinical Endocrinology and Metabolism 76, 559565.Google ScholarPubMed
Hommes, MJT, Romijn, JA, Endert, E & Sauerwein, HP (1991 a) Resting energy expenditure and substrate oxidation in human immunodeficiency virus (HIV)-infected asymptomatic men: HIV affects host metabolism in the early asymptomatic stage. American Journal of Clinical Nutrition 54, 311315.CrossRefGoogle ScholarPubMed
Hommes, MJT, Romijn, JA, Endert, E, Schattenkerk, JKME & Sauerwein, HP (1991 b) Insulin sensitivity and insulin clearance in Human Immunodeficiency Virus-infected men. Metabolism 40, 651656.CrossRefGoogle ScholarPubMed
Hommes, MJT, Romijn, JA, Godfried, MH, Schattenkerk, JKME, Buurman, WA, Endert, E & Sauerwein, HP (1990) Increased resting energy expenditure in human immunodeficiency virus-infected men. Metabolism 39, 11861190.CrossRefGoogle ScholarPubMed
Kotler, DP, Tierney, AR, Brenner, SK, Couture, S, Wang, J & Pierson, RN (1990) Preservation of short-term energy balance in clinically stable patients with AIDS. American Journal of Clinical Nutrition 51, 713.CrossRefGoogle ScholarPubMed
Lieberman, SA, Butterfield, GE, Harrison, D & Hoffman, AR (1994) Anabolic effects of recombinant Insulin-like Growth Factor-I in cachectic patients with the Acquired Immunodeficiency Syndrome. Journal of Clinical Endocrinology and Metabolism 78, 404410.Google ScholarPubMed
Macallan, DC, Mcnurlan, MA, Kurpad, AV, De souza, G, Shetty, PS, Calder, AG & Griffin, GE (1998) Whole body protein metabolism in human pulmonary tuberculosis and undernutrition: Evidence for anabolic block in tuberculosis. Clinical Science 94, 321331.CrossRefGoogle ScholarPubMed
Macallan, DC, Mcnurlan, MA, Milne, E, Calder, AG, Garlick, PJ & Griffin, GE (1995 a) Whole body protein turnover from leucine kinetics and the response to nutrition in Human Immunodeficiency Virus infection. American Journal of Clinical Nutrition 61, 818826.CrossRefGoogle ScholarPubMed
Macallan, DC, Noble, C, Baldwin, C, Foskett, M, Mcmanus, T & Griffin, GE (1993) Prospective analysis of patterns of weight change in stage IV human immunodeficiency virus infection. American Journal of Clinical Nutrition 58, 417424.CrossRefGoogle ScholarPubMed
Macallan, DC, Noble, C, Baldwin, C, Jebb, SA, Prentice, AM, Coward, WA, Sawyer, MB, Mcmanus, TJ & Griffin, GE (1995 b) Energy expenditure and wasting in Human Immunodeficiency Virus infection. New England Journal of Medicine 333, 8388.CrossRefGoogle ScholarPubMed
Mcnurlan, MA, Garlick, PJ, Steigbigel, RT, DeCristofaro, KA, Frost, RA, Lang, CH, Johnson, RW, Santasier, AM, Cabahug, CJ, Fuhrer, J & Gelato, MC (1997) Responsiveness of muscle protein synthesis to growth hormone administration in HIV-infected individuals declines with severity of disease. Journal of Clinical Investigation 100, 21252132.CrossRefGoogle ScholarPubMed
Melchior, JC, Raguin, G, Boulier, A, Bouvet, E, Rigaud, D, Matheron, S, Casalino, E, Vilde, JL, Vachon, F, Couland, JP & Apfelbaum, M (1993) Resting energy expenditure in human immunodeficiency virus-infected patients: comparison between patients with and without secondary infections. American Journal of Clinical Nutrition 57, 614619.CrossRefGoogle ScholarPubMed
Melchior, JC, Salmon, D, Rigaud, D, Leport, C, Bouvet, E, Detruchis, P, Vilde, J, Vachon, F, Couland, J & Apfelbaum, M (1991) Resting energy expenditure is increased in stable, malnourished HIV-infected patients. American Journal of Clinical Nutrition 53, 437441.CrossRefGoogle ScholarPubMed
Melville, S, McNurlan, MA, McHardy, KC, Broom, J, Milne, E, Calder, AG & Garlick, PJ (1989) The role of degradation in the acute control of protein balance in adult man; Failure of feeding to stimulate protein synthesis as assessed by 1–13C leucine infusion. Metabolism 38, 248255.CrossRefGoogle Scholar
Paton, NIJ, Angus, B, Simpson, A, Calder, AG, Milne, E, Chaowagul, W, Newton, P, Suputtamongkol, Y, White, NJ & Griffin, GE (1997 a) Protein metabolism in melioidosis. Transactions of the Royal Society for Tropical Medicine and Hygiene 91, 500 Abstr.Google Scholar
Paton, NIJ, Newton, P, Ross, H, Cotton, J, Calder, AG, Milne, E, Sharpstone, D, Macallan, DC, Gazzard, B & Griffin, GE (1997 b) Growth hormone therapy during acute opportunistic infections in AIDS has a protein-sparing effect. Proceedings of 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, vol. 1, p. 246 Abstr.Google Scholar
Paton, NIJ, Newton, PJ, Sharpstone, DR, Ross, HM, Cotton, J, Calder, AG, Milne, E, Elia, M, Shah, S, Macallan, DC, Gazzard, BG & Griffin, GE (1998) Short-term growth hormone administration at the time of opportunistic infections in HIV-positive patients. New England Journal of Medicine (In the Press).Google Scholar
Rakotoambinia, B, Raynaud, JJ, Melchior, JC, Crenn, P, Thuillier, F & Messing, B (1996) Whole body protein turnover assessed with leucine and glutamine kinetics in vivo at an early stage of human immunodeficiency virus infection. Clinical Nutrition 15, Suppl. 1, 13 Abstr.CrossRefGoogle Scholar
Schambelan, M, Mulligan, K, Grunfeld, C, Daar, ES, Lamarca, A, Kotler, DP, Wang, J, Bozzette, SA & Breitmeyer, JB (1996) Recombinant human growth hormone in patients with HIV- associated wasting. A randomized, placebo-controlled trial. Annals of Internal Medicine 125, 873882.CrossRefGoogle ScholarPubMed
Schwenk, A, Hoffer-Belitz, E, Jung, B, Kremer, G, Burger, B, Salzberger, B, Diehl, V & Schrappe, M (1996) Resting energy expenditure, weight loss and altered body composition in HIV infection. Nutrition 12, 595601.CrossRefGoogle ScholarPubMed
Serwadda, D, Sewankambo, NK, Carswell, JW, Bayley, AC, Tedder, RS, Weiss, RA, Mugerwa, RD, Lwegaba, A, Kirya, GB, Downing, RG, Clayden, SA & Dalgleish, AG (1985) Slim disease: a new disease in Uganda and its association with HTLV-III infection. Lancet ii, 849852.CrossRefGoogle Scholar
Sharpstone, DR, Murray, CP, Ross, HM, Hancock, MR, Phelan, MS, Crane, RC, Menzies, IS, Reaveley, DA, Lepri, AC, Gazzard, BG (1996) Energy balance in asymptomatic HIV infection. AIDS 10, 13771384.CrossRefGoogle ScholarPubMed
Sheehan, LA, Macallan, DC & Griffin, GE (1998) Determinants of energy intake and energy expenditure in HIV and AIDS. Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology (In the Press).Google Scholar
Stein, TP, Nutinsky, C, Condoluci, D, Schluter, MD & Leskiw, MJ (1990) Protein and energy substrate metabolism in AIDS patients. Metabolism 39, 876881.CrossRefGoogle ScholarPubMed
Streat, SJ, Beddoe, AH & Hill, GL (1987) Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. Journal of Trauma 27, 262266.CrossRefGoogle Scholar
Suttmann, U, Ockenga, J, Hoogestraat, L, Selberg, O, Schedel, I, Deicher, H & Muller, MJ (1993) Resting energy expenditure and weight loss in human immunodeficiency virus-infected patients. Metabolism 42, 11731179.CrossRefGoogle ScholarPubMed
Teixeira, A, Leu, JC, Honderlick, P, Trylesinski, A & Zucman, D (1997) Variation in body weight and plasma viral load in HIV patients treated with tritherapy including a protease inhibitor. Nutrition 13, 269 Abstr.CrossRefGoogle Scholar